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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26889 of the 27780 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 17,526–17,550 of 27,780 studies, newest first · page 702 of 1112.

February 2015 12

  1. 2015-02-01

    Downregulated miR-29c correlates with increased BACE1 expression in sporadic Alzheimer's disease

    ✓ Peer-reviewed Risk genes beyond APOE International journal of clinical and experimental pathology

    Key finding: Beta-site Amyloid precursor protein Cleaving Enzyme 1 (BACE1) is conceived as a potential target for therapies against Alzheimer disease (AD) which is characterized by the accumulation of plaques formed of short β-amyloid (APPβ) peptides. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2015-02-01

    Parkinson's disease iron deposition caused by nitric oxide-induced loss of β-amyloid precursor protein

    ✓ Peer-reviewed Risk genes beyond APOE The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: We reported previously that the Alzheimer-associated β-amyloid precursor protein (APP) facilitates neuronal iron export. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2015-02-01

    Coding mutations in SORL1 and Alzheimer disease

    ✓ Peer-reviewed Risk genes beyond APOE Annals of neurology

    Key finding: Common single nucleotide polymorphisms in the SORL1 gene have been associated with late onset Alzheimer disease (LOAD), but causal variants have not been fully characterized nor has the mechanism been established. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2015-02-01

    Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice

    ✓ Peer-reviewed Risk genes beyond APOE The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: Klotho is a key modulator of the aging process and, when overexpressed, extends mammalian lifespan, increases synaptic plasticity, and enhances cognition. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2015-02-01

    Invited review: Frontotemporal dementia caused by microtubule-associated protein tau gene (MAPT) mutations: a chameleon for neuropathology and neuroimaging

    ✓ Peer-reviewed Lewy body dementia Neuropathology and applied neurobiology

    Key finding: Hereditary frontotemporal dementia associated with mutations in the microtubule-associated protein tau gene (MAPT) is a protean disorder.

    Full summary, score breakdown and related studies → Original source

  6. 2015-02-01

    Invited review: Neuropathology of tauopathies: principles and practice

    ✓ Peer-reviewed Lewy body dementia Neuropathology and applied neurobiology

    Key finding: Mutations in the gene encoding the microtubule-associated protein tau are associated with frontotemporal dementia and parkinsonism linked to chromosome 17. +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2015-02-01

    Enhancement of neurogenesis and memory by a neurotrophic peptide in mild to moderate traumatic brain injury

    ✓ Peer-reviewed Down syndrome and Alzheimer's Neurosurgery

    Key finding: Long-term treatment with Peptide 6 enhances the pool of newborn neurons in the dentate gyrus, prevents neuronal loss in CA1 and parietal cortex, preserves the dendritic and synaptic architecture in the hippocampus, and improves performance on a hippocampus-dependent memory task in TBI mice. +2 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2015-02-01

    SnapShot: Genetics of ALS and FTD

    ✓ Peer-reviewed Digital health tools Cell

    Key finding: Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are considered to be part of a spectrum. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2015-02-01

    Early cerebral small vessel disease and brain volume, cognition, and gait

    ✓ Peer-reviewed Disparities Annals of neurology

    Key finding: Covert cerebrovascular disease and its consequences on cognitive and gait performance and brain atrophy are manifest in some clinically asymptomatic persons as early as the 5th decade of life. +2 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2015-02-01

    Antihypertensive drugs, prevention of cognitive decline and dementia: a systematic review of observational studies, randomized controlled trials and meta-analyses, with discussion of potential mechanisms

    ✓ Peer-reviewed Prevention and risk CNS drugs

    Key finding: In the seven longitudinal studies assessing the effect of antihypertensive medication on cognitive impairment or cognitive decline, antihypertensive drugs appeared to be beneficial. +3 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2015-02-01

    Medication development for agitation and aggression in Alzheimer disease: review and discussion of recent randomized clinical trial design

    ✓ Peer-reviewed Treatments International psychogeriatrics

    Key finding: This review highlights a great heterogeneity in RCTs design of drugs for A/A in AD and some key methodological issues such as definition of A/A, choice of outcome measures and caregiver participation that could be addressed by an expert consensus to optimize future trials design. +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2015-02-01

    Imaging Amyloidopathy in Parkinson Disease and Parkinsonian Dementia Syndromes

    ✓ Peer-reviewed Biomarkers Clinical and translational imaging

    Key finding: Although individual reports often include only small-to-modest subject numbers, there is overall suggestion that PD patients have a lower incidence of Aβ-amyloid deposition than seen amongst elderly normal subjects, and that Parkinson disease with dementia patients have a lower incidence of Aβ-amyloid deposition than do patients with dementia with Lewy bodies.

    Full summary, score breakdown and related studies → Original source

January 2015 13

  1. 2015-01-31

    Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy

    ✓ Peer-reviewed Inflammation and the immune system Acta neuropathologica communications

    Key finding: Since increased BBB permeability is found in tauopathies without Aß pathology, like PSP, we suspected that tau accumulation alone could not only be sufficient, but even more important than Aß for BBB damage. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2015-01-30

    Rationales that Providers and Family Members Cited for the Use of Antipsychotic Medications in Nursing Home Residents with Dementia

    ✓ Peer-reviewed Clinical safety Journal of the American Geriatrics Society

    Key finding: Major categories of reasons for use of antipsychotic medications in the 204 NH residents in the study sample were behavioral (n = 171), psychiatric (n = 159), emotional states (n = 105), and cognitive diagnoses or symptoms (n = 114). +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2015-01-30

    Cerebral small vessel disease and chronic kidney disease

    ✓ Peer-reviewed Vascular contributions Journal of stroke

    Key finding: Chronic kidney disease has been reported to be associated with silent brain infarcts, cerebral white matter lesions, and cerebral microbleeds, independently of vascular risk factors.

    Full summary, score breakdown and related studies → Original source

  4. 2015-01-30

    A systematic review and meta-analysis of magnetic resonance imaging measurement of structural volumes in posttraumatic stress disorder

    ✓ Peer-reviewed Hippocampus size on brain scans Psychiatry research

    Key finding: Posttraumatic stress disorder (PTSD) is a debilitating condition associated with mild to moderate cognitive impairment and with a prevalence rate of up to 22% in veterans. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2015-01-30

    Neuroinflammation in Alzheimer's disease

    ✓ Peer-reviewed Inflammation and the immune system Neuropsychiatric disease and treatment

    Key finding: However, it has become increasingly apparent that neuroinflammation plays a significant role in the pathophysiology of AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2015-01-30

    Nucleus basalis of Meynert revisited: anatomy, history and differential involvement in Alzheimer's and Parkinson's disease

    ✓ Peer-reviewed Lewy body dementia Acta neuropathologica

    Key finding: Extensive review of the literature suggests that there is a caudorostral pattern of neuronal loss within the nbM in AD brains. +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2015-01-30

    Cerebral amyloid angiopathy: emerging concepts

    ✓ Peer-reviewed Getting a diagnosis Journal of stroke

    Key finding: Moreover, cSS is closely associated with transient focal neurological episodes (TFNE).

    Full summary, score breakdown and related studies → Original source

  8. 2015-01-29

    Histone deacetylases (HDACs) in frontotemporal lobar degeneration

    ✓ Peer-reviewed Lewy body dementia Neuropathology and Applied Neurobiology

    Key finding: We found a significantly greater intensity of cytoplasmic immunostaining for HDAC4 and HDAC6 in granule cells of the dentate gyrus in cases of FTLD overall compared with controls, and specifically in cases of FTLD tau‐ P icks compared with FTLD tau‐ MAPT and controls. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2015-01-29

    Principles and management of neuropsychiatric symptoms in Alzheimer’s dementia

    ✓ Peer-reviewed Clinical safety Alzheimer's Research & Therapy

    Key finding: Recent neurobiological studies have used new neuroimaging techniques to elucidate behaviorally relevant circuits and networks associated with these subsyndromes. +1 more finding

    Full summary, score breakdown and related studies → Original source

  10. 2015-01-29

    Cognitive impairment in patients with AIDS - prevalence and severity

    ✓ Peer-reviewed Clinical safety HIV/AIDS (Auckland, N.Z.)

    Key finding: The associated cognitive disturbance is linked to both viral activity and inflammatory and other mediators from these immune cells that lead to the damage associated with HIV-associated neurocognitive disorders, a general term given for these disturbances.

    Full summary, score breakdown and related studies → Original source

  11. 2015-01-29

    Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

    ✓ Peer-reviewed Inflammation and the immune system Nature Communications

    In Alzheimer’s disease (AD), β-amyloid (Aβ) plaques are tightly enveloped by microglia processes, but the significance of this phenomenon is unknown.

    Full summary, score breakdown and related studies → Original source

  12. 2015-01-29

    TREM2 regulates microglial cell activation in response to demyelination in vivo

    ✓ Peer-reviewed TREM2 and immune genetics Acta neuropathologica

    Key finding: Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial immunoreceptor whose loss-of-function mutations in humans cause presenile dementia, while genetic variants are associated with increased risk of neurodegenerative diseases. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2015-01-28

    PART is part of Alzheimer disease

    ✓ Peer-reviewed Disease mechanisms Acta neuropathologica

    Key finding: On the other hand, entorhinal-hippocampal tau pathology is an invariant feature of AD and is always associated with its development.

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →