Home › Research › Prevention trials
Baseline predictors of neurophysiological response to combined physical and cognitive training in older adults with subjective cognitive decline
Hsien-Chun Chiu, Yu-Wei Hsieh, Chia‐Hsiung Cheng. BMC Geriatrics, 2026-03-04
Topic: Risk, prevention and care in population studies
Regression analysis indicated that APOE ε4 non-carriers showed significantly greater improvement in MMN amplitude (β = ‒0.449, p = 0.027). Additionally, lower baseline levels of physical activity demonstrated a trend toward association with greater MMN gains (β = ‒0.392, p = 0.050), suggesting that individuals with more sedentary lifestyles may derive greater benefit from the intervention. APOE ε4 carrier status and baseline physical activity levels may be associated with the effectiveness of multidomain interventions in older adults with SCD.
Key findings
- Regression analysis indicated that APOE ε4 non-carriers showed significantly greater improvement in MMN amplitude (β = ‒0.449, p = 0.027).
- Additionally, lower baseline levels of physical activity demonstrated a trend toward association with greater MMN gains (β = ‒0.392, p = 0.050), suggesting that individuals with more sedentary lifestyles may derive greater benefit from the intervention.
- APOE ε4 carrier status and baseline physical activity levels may be associated with the effectiveness of multidomain interventions in older adults with SCD.
Why it matters
In this randomized controlled trial, APOE ε4 non-carriers showed significantly greater improvement in MMN amplitude, and lower baseline physical activity showed a trend toward greater MMN gains. These findings suggest that APOE ε4 carrier status and baseline physical activity may be associated with how well multidomain interventions work in older adults with subjective cognitive decline, but they do not show a treatment or cure.
New to this subject? Start with our plain-English guide: Prevention →
Study details
- Study designrandomized controlled trial
- Participants21
- Evidence strengthHigh
How this study scored 53/100
Published in a peer-reviewed journal, and it is a randomised controlled trial. Scored zero for effect reported because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (BMC Geriatrics) |
| Journal's citation record | 2 / 4 | BMC Geriatrics: journal h-index 153 (OpenAlex, 2026-10-29) |
| Study design | 11 / 12 | A randomised controlled trial |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 1 / 4 | 21 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 1 / 2 | Randomised (as stated in the record) |
| Times cited | 0 / 7 | Cited 0 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.0 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | 0 / 6 | Cited 0.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Chia‐Hsiung Cheng: h-index 25 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Chang Gung Memorial Hospital: institution h-index 424 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41781884) |
| Free to read | 2 / 2 | Free to read |
| Total | 53 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Chiu, H.-C., Hsieh, Y.-W., & Cheng, C. (2026). Baseline predictors of neurophysiological response to combined physical and cognitive training in older adults with subjective cognitive decline. BMC Geriatrics. https://doi.org/10.1186/s12877-026-07270-8
Vancouver
Chiu H.-C, Hsieh Y.-W, Cheng C. Baseline predictors of neurophysiological response to combined physical and cognitive training in older adults with subjective cognitive decline. BMC Geriatrics. 2026. doi:10.1186/s12877-026-07270-8. PMID: 41781884.
BibTeX
@article{chiu2026-41781884,
author = {Chiu, Hsien-Chun and Hsieh, Yu-Wei and Cheng, Chia‐Hsiung},
title = {{Baseline predictors of neurophysiological response to combined physical and cognitive training in older adults with subjective cognitive decline}},
journal = {BMC Geriatrics},
year = {2026},
doi = {10.1186/s12877-026-07270-8},
pmid = {41781884},
url = {https://doi.org/10.1186/s12877-026-07270-8}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here. Showing 12 of 13.
Related studies in Prevention trials
Also tagged “cognitive-function”
1,118 studies in the library carry the topic tag “cognitive-function”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 1,118 tagged studies.