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Multivariate patterns of plasma biomarkers predict region-specific Alzheimer's pathology and cognitive decline across independent cohorts
Jafar Zamani, Amirali Vahid, Edward N Wilson, S M Hadi Hosseini, Alzheimer's Disease Neuroimaging Initiative. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026-03
Topic: Plasma and spinal-fluid biomarkers
Specific plasma biomarker combinations predicted amyloid burden in the precuneus, tau in the entorhinal cortex, hippocampal atrophy, and memory decline. Models trained in one cohort accurately predicted outcomes in the other, confirming cross-cohort generalizability. Distinct plasma signatures reflect underlying AD pathways, supporting the use of blood-based biomarkers as cost-effective, noninvasive tools for early detection, disease monitoring, and individualized risk profiling.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Zamani, J., Vahid, A., Wilson, E. N., Hosseini, S. M. H., & Alzheimer's Disease Neuroimaging Initiative. (2026). Multivariate patterns of plasma biomarkers predict region-specific Alzheimer's pathology and cognitive decline across independent cohorts. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1002/alz.71265
Vancouver
Zamani J, Vahid A, Wilson EN, Hosseini SMH, Alzheimer's Disease Neuroimaging Initiative. Multivariate patterns of plasma biomarkers predict region-specific Alzheimer's pathology and cognitive decline across independent cohorts. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2026. doi:10.1002/alz.71265. PMID: 41830135.
BibTeX
@article{zamani2026-41830135,
author = {Zamani, Jafar and Vahid, Amirali and Wilson, Edward N and Hosseini, S M Hadi and {Alzheimer's Disease Neuroimaging Initiative}},
title = {{Multivariate patterns of plasma biomarkers predict region-specific Alzheimer's pathology and cognitive decline across independent cohorts}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2026},
doi = {10.1002/alz.71265},
pmid = {41830135},
url = {https://doi.org/10.1002/alz.71265}
}
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Key findings
- Specific plasma biomarker combinations predicted amyloid burden in the precuneus, tau in the entorhinal cortex, hippocampal atrophy, and memory decline.
- Models trained in one cohort accurately predicted outcomes in the other, confirming cross-cohort generalizability.
- Distinct plasma signatures reflect underlying AD pathways, supporting the use of blood-based biomarkers as cost-effective, noninvasive tools for early detection, disease monitoring, and individualized risk profiling.
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Study details
- Evidence strengthModerate
How this study scored 52/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 29 of the 56 points we could judge it on, which is 52 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41830135) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 29 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 29 of the 56 points we could judge it on is 52 out of 100. |
| Total | 52 / 100 | — |
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