Newest studies

A clustering approach based on neuropsychological testing to detect early signs of probable MCI among community-dwelling older adults

78/100 ✓ Peer-reviewed Clinical trials Frontiers in aging neuroscience

Key finding: Individuals with cognitive profiles consistent with probable executive MCI were identified using simple assessments of global cognition, memory and executive functions in a community-dwelling older population. +1 more finding

• Clinical Trials
• Early Stage
• Diagnosis

Full summary, score breakdown and related studies → Original source

Artificial Intelligence That Changes Clinical Neurology Practice: Translating Algorithms Into Actionable Care

40/100 ✓ Peer-reviewed Health systems and care delivery Journal of clinical neurology (Seoul, Korea)

Key finding: The most clinically advanced examples come from acute stroke, where imaging-based selection, large-vessel occlusion detection, and automated notification are linked to urgent, pathway-defined interventions. +4 more findings

• Digital Tools

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Streamlining eligibility assessment for Alzheimer's disease-modifying therapies: Prediction of MMSE scores using the digital clock and recall

43/100 ✓ Peer-reviewed Cognitive tests and assessment Frontiers in Digital Health

Key finding: The machine learning model predicted MMSE scores with a root-mean-squared error (RMSE) of 2.43 in the BH test set. +3 more findings

• Diagnosis
• Treatments
• Digital Tools

Full summary, score breakdown and related studies → Original source

The relationship of neighborhood socioeconomic disadvantage and pretreatment cancer‐related cognitive impairment in women with breast cancer: A post hoc analysis of a randomized controlled trial

57/100 ✓ Peer-reviewed Risk factors Cancer

Key finding: On average, participants were aged 63 years and had 16 years of education. +4 more findings

• Clinical Trials
• Health Equity

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Mapping dementia risk factors and their interactions in Denmark: a nationwide cohort study

63/100 ✓ Peer-reviewed How common it is The Lancet Public Health

Key finding: The overall PAF for dementia in Denmark was 37·8% (95% CI 35·6-40·0) for the assessed risk factors. +3 more findings

• Risk Factors

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Effect of initiating an ARB- versus ACEI-based regimen on dementia risk, a target trial emulation of 2.5 million US Veterans

16/100 ⚠ Preprint — not yet peer-reviewed Drug development medRxiv

Key finding: Among 2,577,000 Veterans (mean age, 63 years; 4.5% female; 65% White; 15% Black), 10% initiated ARBs and 90% initiated ACEIs. +4 more findings

• Risk Factors
• Clinical Trials

Scored 50 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Trisomy 21 cerebral organoids exhibit Alzheimer’s disease amyloid and apolipoprotein E co-pathologies

16/100 ⚠ Preprint — not yet peer-reviewed Down syndrome and Alzheimer's bioRxiv

Key finding: Taken together, our findings provide novel insights into molecular mechanisms that may contribute to DS-AD and indicate that apoE plays an important role in the disease process.

• Genetics
• Down Syndrome
• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Nonlinear Association of Length of Stay With In-Hospital Mortality in Alzheimer’s Disease Hospitalizations: Admission-Only vs Inpatient-Course Prediction Using Explainable Machine Learning

16/100 ⚠ Preprint — not yet peer-reviewed Clinical safety Preprints.org

Key finding: Among 11,377 AD hospitalizations, 600 in-hospital deaths occurred (5.27%). +4 more findings

• Care Services

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Understanding end-of-life multimorbidity: An analysis of multiple causes of death in Denmark

16/100 ⚠ Preprint — not yet peer-reviewed End-of-life care medRxiv

Key finding: We examined how often each diagnosed disease appeared on the certificate, its location and selection as the UCD, factors associated with its appearance (logistic regression), disease-specific mortality (multiple decrement life tables), and disease associations (Cause of Death Association Indicator, CDAI). +2 more findings

• End-of-Life Care

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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TrustPGS: When can a polygenic score be trusted? A per-individual reliability framework across ancestries

16/100 ⚠ Preprint — not yet peer-reviewed Clinical trials bioRxiv

Key finding: The framework rests on two axes calibrated on a discovery cohort, the consensus of a Bayesian posterior-sample ensemble and the directional agreement of the top-magnitude linkage-disequilibrium blocks. +4 more findings

• Genetics
• Risk Factors

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Phenolic chemotypic diversity in Tunisian Hertia cheirifolia populations: influence of plant organs and phenological stages on antioxidant and anti-acetylcholinesterase activities

16/100 ⚠ Preprint — not yet peer-reviewed Treatments Research Square

Key finding: H. cheirifolia phenolic extracts exhibit potent, mechanism-specific antioxidant activity and promising AChE inhibition, validating traditional use in neurological complaints. +3 more findings

• Treatments

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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In-clinic validation of a smartphone-based finger tapping test for use in neurodegenerative and neurological populations

16/100 ⚠ Preprint — not yet peer-reviewed Cognitive tests and assessment medRxiv

Key finding: These findings support mApp-FTT validity as a measure of motor function across neurodegenerative conditions. +3 more findings

• Digital Tools
• Other Dementias

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Guiding the Ethics of Locator Devices in Dementia Care: Tutorial on Developing a Question-Based Ethical Framework

40/100 ✓ Peer-reviewed Clinical safety Journal of Medical Internet Research

Key finding: The resulting framework is organized around 3 themes-vision, process, and impact-each containing guiding questions that encourage dialogical reflection and decision-making. +3 more findings

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Associations among cognitive performance, VCAM-1, and GFAP in black adults: The ARCHES study

49/100 ✓ Peer-reviewed Risk factors Neurobiology of Aging

Key finding: VCAM-1 and GFAP did not show independent associations with PACC; however, the VCAM-1 × GFAP interaction was significant (β = -1.36 × 10⁻⁶, 95% CI: -2.43 × 10⁻⁶ to -2.94 × 10⁻⁷, p = 0.013; FDR p = 0.030; standardized β = -0.118) and remained significant after additional adjustment for ADI, BMI, and APOE ε4 status. +2 more findings

• Biomarkers
• Diagnosis
• Genetics

Full summary, score breakdown and related studies → Original source

Ten-Year Cost Projections for Medicare Beneficiaries 65 Years or Older With HIV

43/100 ✓ Peer-reviewed Health systems and care delivery JAMA Network Open

Key finding: The simulated cohort was informed by 111 600 PWH enrolled in Medicare at the start of 2026 (mean [SD] age, 70.9 [5.0] years; 77% male). +4 more findings

• Policy

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Traumatic Brain Injury Increases Risk of Psychiatric Disorders Following Neurological Disease: Evidence from the UK Biobank Cohort

16/100 ⚠ Preprint — not yet peer-reviewed Disparities medRxiv

Key finding: Lifetime TBI exposure is associated with increased likelihood and long-term risk of psychiatric disorders in individuals with dementia, stroke, and Parkinson’s disease, with mood disorders being the most consistent outcome across conditions. +3 more findings

• Risk Factors

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Effect of Intensive vs Standard Blood Pressure Control According to APOE ε4 Genotype: A Secondary Analysis of SPRINT

16/100 ⚠ Preprint — not yet peer-reviewed Disparities medRxiv

Key finding: In SPRINT, intensive vs standard SBP control yielded a significantly larger 4-year absolute risk reduction in dementia among APOE ε4 carriers (−1.7%) than non-carriers (0.2%; P-interaction = .045); the relative-scale interactions were directionally consistent but not significant. +2 more findings

• Genetics
• Clinical Trials
• Risk Factors

Scored 50 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Determinants of fractal motor activity regulation: insights from a large community-dwelling multi-ethnic population

16/100 ⚠ Preprint — not yet peer-reviewed Disparities Research Square

Key finding: We found opposite effects of age on FMAR at both short and long time scales, respectively (ßAge=0.014, 95% C.I. [0.009,0.019] and ßAge=-0.015, 95% C.I. [-0.026,-0.005]), as well as differences between women and men at long time scales (ßSexMen=+0.028, 95% C.I. [0.012,0.044]). +4 more findings

• Health Equity

Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Turkish Adaptation of the Supportive and Palliative Care Indicators Tool (SPICT): A Validity and Reliability Study

16/100 ⚠ Preprint — not yet peer-reviewed End-of-life care Research Square

Key finding: The SPICT-TR is a culturally adapted, valid, and reliable assessment tool for identifying patients with palliative care needs within the Turkish healthcare system. +3 more findings

• End-of-Life Care

Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Clinical Efficacy of Comprehensive Geriatric Assessment in Patients Undergoing Hemodialysis: A Retrospective Observational Study

16/100 ⚠ Preprint — not yet peer-reviewed Health systems and care delivery Preprints.org

Key finding: Functional decline, as assessed by CGA, was more prominent in patients undergoing hemodialysis than in those not undergoing hemodialysis. +2 more findings

Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Development of a metabolomics-based index to monitor dietary effects on chronic inflammation: The Dietary Metabolomics Inflammation Index

16/100 ⚠ Preprint — not yet peer-reviewed Prevention and risk bioRxiv

Key finding: DMII provides a metabolomics-based framework for assessing diet-related chronic inflammation using metabolomics data. +3 more findings

• Lifestyle
• Brain Biology

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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The Microglial Protein sTREM2 Inhibits the Bacterial Functional Amyloid CsgA and Suppresses Amyloid-Dependent Biofilm Formation

16/100 ⚠ Preprint — not yet peer-reviewed TREM2 and immune genetics bioRxiv

Key finding: Kinetic modeling indicated that sTREM2 slowed primary and secondary nucleation, rather than altering fiber elongation. +2 more findings

• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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APOLIPOPROTEIN E TRONG CHUYỂN HÓA LIPID VÀ BỆNH ALZHEIMER

28/100 ✓ Peer-reviewed Genetics Tạp chí Sinh lý học Việt Nam

Key finding: Các dạng đồng phân của một loại protein vận chuyển lipid - apolipoprotein E (APOE), có khả năng làm thay đổi nguy cơ mắc cũng như khả năng phục hồi trong một số bệnh thoái hóa thần kinh, trong đó có bệnh Alzheimer khởi phát muộn (LOAD). +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Clinical outcomes after antipsychotic discontinuation in nursing home residents with dementia: a nationwide cohort study

52/100 ✓ Peer-reviewed Treatments Alzheimer's Research & Therapy

Key finding: Among nursing home residents with dementia, discontinuing long-term antipsychotic medication use was associated with lower risks of hospitalization, pneumonia, and urinary tract infections, suggesting clinical benefits in this population. +3 more findings

• Treatments
• Care Services
• Side Effects

Full summary, score breakdown and related studies → Original source

Effects of high-intensity interval training with or without resistance training on Alzheimer’s disease brain signatures in individuals with coronary artery disease: the Heart-Brain randomized controlled trial

16/100 ⚠ Preprint — not yet peer-reviewed Clinical trials medRxiv

Key finding: A 12-week HIIT+RT intervention was more effective than HIIT alone in increasing the thickness/volume signature in individuals with CAD, yet no differences were observed compared to UC and the interventions did not affect the GMMD signature. +4 more findings

• Clinical Trials

Scored 55 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source