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68/100

✓ Peer-reviewed alzhub usefulness score 68 out of 100. Biomarkers

Topic: Plasma and spinal-fluid biomarkers

MES-defined cognitive impairment (≤-2 standard deviation [SD] deviation after adjustment for demographics) was identified in 12.4% of participants. In cognitively unimpaired (CU) individuals, age-specific thresholds targeting a PPV of 0.7 yielded an overall p-tau217 positivity rate of 11.8%, increasing from 3.5% (< 60 years) to 6.3% (60-70 years) and 25.9% (≥70 years). Among cognitively impaired (CI) participants, 26.6% were p-tau217 positive. This framework supports practical integration of plasma biomarkers into community-based screening, with longitudinal follow-up needed to further refine threshold selection. HIGHLIGHTS: Regression-based residual method reduced education bias, identifying 12.4% with cognitive impairment individuals. Fully automated chemiluminescent assay enabled practical, large-scale biomarker implementation. Brief screening strategy supports early detection, clinical trial recruitment, and resource allocation in under-resourced regions.

Key findings

MES-defined cognitive impairment (≤-2 standard deviation [SD] deviation after adjustment for demographics) was identified in 12.4% of participants.
In cognitively unimpaired (CU) individuals, age-specific thresholds targeting a PPV of 0.7 yielded an overall p-tau217 positivity rate of 11.8%, increasing from 3.5% (< 60 years) to 6.3% (60-70 years) and 25.9% (≥70 years).
Among cognitively impaired (CI) participants, 26.6% were p-tau217 positive.
This framework supports practical integration of plasma biomarkers into community-based screening, with longitudinal follow-up needed to further refine threshold selection.
HIGHLIGHTS: Regression-based residual method reduced education bias, identifying 12.4% with cognitive impairment individuals.

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Study details

Study designlongitudinal study
Effect size12.4%; 11.8%; 3.5%
Evidence strengthModerate

How this study scored 68/100

Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for sample size, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 38 of the 56 points we could judge it on, which is 68 out of 100.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association)
Journal's citation record	— / 4	No journal record from OpenAlex — left out of this score
Study design	7 / 12	A longitudinal study following the same people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	5 / 5	2026 — within 1 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	— / 7	No citation count (not found in OpenAlex) — left out of this score
Citations per year	— / 5	No citation count or no year — left out of this score
Impact for its field and year	— / 6	No field-weighted citation impact (OpenAlex has none yet) — left out of this score
Cited by studies here	— / 6	Not yet checked against this library's citation graph — left out of this score
Still being cited	— / 4	No yearly citation counts — left out of this score
Senior author's track record	— / 4	Senior author's record not available — left out of this score
Institution's track record	— / 3	No institution listed in OpenAlex — left out of this score
Multi-centre collaboration	— / 3	Institutions not listed — left out of this score
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41804834)
Free to read	— / 2	Access not recorded — left out of this score
Points	38 / 56	Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 38 of the 56 points we could judge it on is 68 out of 100.
Total	68 / 100	—

What each of these 20 components measures, and what this score is not →

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Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Chen, S., Hao, X., Ma, K., Li, R., Wen, C., Han, X., et al. (2026). Implementing plasma p-tau217 and cognitive testing for Alzheimer's screening in low-education populations in central China. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1002/alz.71251

Vancouver

Chen S, Hao X, Ma K, Li R, Wen C, Han X, et al. Implementing plasma p-tau217 and cognitive testing for Alzheimer's screening in low-education populations in central China. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2026. doi:10.1002/alz.71251. PMID: 41804834.

BibTeX

@article{chen2026-41804834,
  author  = {Chen, Shuai and Hao, Xiaodi and Ma, Kai and Li, Rong and Wen, Changming and Han, Xinsheng and Zheng, Wenquan and Ruan, Shiwang and others},
  title   = {{Implementing plasma p-tau217 and cognitive testing for Alzheimer's screening in low-education populations in central China}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2026},
  doi     = {10.1002/alz.71251},
  pmid    = {41804834},
  url     = {https://doi.org/10.1002/alz.71251}
}

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