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How neuroinflammation contributes to neurodegeneration
Ransohoff RM.. Science (New York, N.Y.), 2016-08-01
Topic: Brain proteins, microglia and lab models
Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and frontotemporal lobar dementia are among the most pressing problems of developed societies with aging populations. Neurons carry out essential functions such as signal transmission and network integration in the central nervous system and are the main targets of neurodegenerative disease. In this Review, I address how the neuron's environment also contributes to neurodegeneration. Maintaining an optimal milieu for neuronal function rests with supportive cells termed glia and the blood-brain barrier. Accumulating evidence suggests that neurodegeneration occurs in part because the environment is affected during disease in a cascade of processes collectively termed neuroinflammation. These observations indicate that therapies targeting glial cells might provide benefit for those afflicted by neurodegenerative disorders.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Ransohoff, R. M. (2016). How neuroinflammation contributes to neurodegeneration. Science (New York, N.Y.). https://doi.org/10.1126/science.aag2590
Vancouver
Ransohoff RM. How neuroinflammation contributes to neurodegeneration. Science (New York, N.Y.). 2016. doi:10.1126/science.aag2590. PMID: 27540165.
BibTeX
@article{ransohoff2016-27540165,
author = {Ransohoff, R. M.},
title = {{How neuroinflammation contributes to neurodegeneration}},
journal = {Science (New York, N.Y.)},
year = {2016},
doi = {10.1126/science.aag2590},
pmid = {27540165},
url = {https://doi.org/10.1126/science.aag2590}
}
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Key findings
- Accumulating evidence suggests that neurodegeneration occurs in part because the environment is affected during disease in a cascade of processes collectively termed neuroinflammation.
- These observations indicate that therapies targeting glial cells might provide benefit for those afflicted by neurodegenerative disorders.
Why it matters
This review suggests that neuroinflammation, involving glial cells and the blood-brain barrier, contributes to neurodegeneration in diseases including Alzheimer's disease, and that therapies targeting glial cells might help. It is a discussion of a possible approach, not a proven treatment, cure or prevention.
Study details
- Evidence strengthLow
How this study scored 58/100
Published in a top-tier journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 10 / 10 | Tier 1 — top-tier general journal (Science (New York, N.Y.)) |
| Journal's citation record | 4 / 4 | Science: journal h-index 1,754 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 1,961 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 163.4 citations a year over 12 year(s) since 2016 |
| Impact for its field and year | 6 / 6 | Cited 74.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 4 / 6 | Cited by 42 other studies in this library |
| Still being cited | 4 / 4 | Cited 537 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Richard M. Ransohoff: h-index 128 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Biogen (United States): institution h-index 495 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 27540165) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 58 / 100 | — |
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