alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 15,626–15,650 of 27,380 studies, newest first · page 626 of 1096.

November 2016 25

  1. 2016-11-17

    Patient and Caregiver Interplay in Behavioral and Psychological Symptoms of Dementia: Family Caregiver's Experience

    ✓ Peer-reviewed Caregiving Clinical nursing research

    Key finding: The purpose of this study was to identify family caregivers' experiences in managing the behavioral and psychological symptoms of dementia (BPSD) with particular focus on their interpersonal interactions with patient with dementia.

    Full summary, score breakdown and related studies → Original source

  2. 2016-11-17

    Personalising exercise recommendations for brain health: considerations and future directions

    ✓ Peer-reviewed Prevention trials British journal of sports medicine

    Key finding: Physical activity-unstructured and structured-is a promising, cost-effective strategy for the promotion of brain health. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2016-11-17

    The Eye As a Biomarker for Alzheimer's Disease

    ✓ Peer-reviewed Brain scans and imaging Frontiers in neuroscience

    Key finding: Though effective, these methods are not widely available due to issues such as the difficulty in acquiring samples, lack of infrastructure or high cost. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2016-11-17

    A comprehensive database of published tDCS clinical trials (2005-2016)

    ✓ Peer-reviewed Clinical safety Neurophysiologie clinique = Clinical neurophysiology

    Key finding: Transcranial direct current stimulation (tDCS) is a technique of noninvasive cortical stimulation allowing significant modification of brain functions. +1 more finding

    Full summary, score breakdown and related studies → Original source

  5. 2016-11-16

    Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial

    ✓ Peer-reviewed Drug development Lancet (London, England)

    Key finding: The prespecified primary analyses did not show any treatment benefit at either of the doses tested for the coprimary outcomes (change in ADAS-Cog score compared with control [n=354, 6·32, 95% CI 5·31-7·34]: 75 mg LMTM twice a day [n=257] -0·02, -1·60 to 1·56, p=0·9834, 125 mg LMTM twice a day [n=250] -0·43, -2·06 to 1·20, p=0·9323; change in ADCS-ADL score compared with control [-8·22, 95% CI -9·63 to -6·82]: 75 mg LMTM twice a day -0·93, -3·12 to 1·26, p=0·8659; 125 mg LMTM twice a day -0·34, -2·61 to 1·93, p=0·9479). +2 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2016-11-16

    MAXCOG-Maximizing Cognition: A Randomized Controlled Trial of the Efficacy of Goal-Oriented Cognitive Rehabilitation for People with Mild Cognitive Impairment and Early Alzheimer Disease

    ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

    Key finding: The MAXCOG intervention is effective in improving goal performance and satisfaction in clients with MCI and early dementia. +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2016-11-16

    Genetically decreased vitamin D and risk of Alzheimer disease

    ✓ Peer-reviewed Genetics Neurology

    Key finding: Our results provide evidence supporting 25OHD as a causal risk factor for AD. +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2016-11-14

    Computerized Cognitive Training in Older Adults With Mild Cognitive Impairment or Dementia: A Systematic Review and Meta-Analysis

    ✓ Peer-reviewed Prevention trials The American journal of psychiatry

    Key finding: CCT is efficacious on global cognition, select cognitive domains, and psychosocial functioning in people with mild cognitive impairment. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2016-11-14

    Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension

    ✓ Peer-reviewed Risk factors The Journal of clinical investigation

    Key finding: These findings unveil a pathogenic role of PVMs in the neurovascular and cognitive dysfunction associated with hypertension and identify these cells as a putative therapeutic target for diseases associated with cerebrovascular oxidative stress.

    Full summary, score breakdown and related studies → Original source

  10. 2016-11-12

    Antipsychotic prescribing patterns in a Medicare Advantage population of older individuals with dementia

    ✓ Peer-reviewed Health systems and care delivery Journal of Mental Health

    Key finding: Of the 8688 individuals in the Medicare Advantage population with a dementia diagnosis, 1061 (12.2%) received an antipsychotic medication. +3 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2016-11-12

    Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline

    ✓ Peer-reviewed Inflammation and the immune system Experimental gerontology

    Key finding: In particular, aging impairs the increase in cerebral blood flow triggered by neural activation (termed neurovascular coupling or functional hyperemia), a critical mechanism that matches oxygen and nutrient delivery with the increased demands in active brain regions. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2016-11-10

    Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial

    ✓ Peer-reviewed Clinical trials Frontiers in aging neuroscience

    Key finding: Alzheimer's disease (AD) is associated with severe cognitive impairments as well as some metabolic defects. +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2016-11-10

    Network abnormalities and interneuron dysfunction in Alzheimer disease

    ✓ Peer-reviewed Brain scans and imaging Nature reviews. Neuroscience

    Key finding: The function of neural circuits and networks can be controlled, in part, by modulating the synchrony of their components' activities. +4 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2016-11-10

    HNE-modified proteins in Down syndrome: Involvement in development of Alzheimer disease neuropathology

    ✓ Peer-reviewed Down syndrome and Alzheimer's Free radical biology & medicine

    Key finding: Interestingly, many genes encoded by chromosome 21, in addition to being primarily linked to amyloid-beta peptide (Aβ) pathology, are responsible for increased oxidative stress (OS) conditions that also result as a consequence of reduced antioxidant system efficiency. +2 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2016-11-09

    Can mindfulness-based interventions influence cognitive functioning in older adults? A review and considerations for future research

    ✓ Peer-reviewed Prevention trials Aging & mental health

    Key finding: We conclude that eight-week MBI for older adults are feasible, but results on cognitive improvement are inconclusive due a limited number of studies, small sample sizes, and a high risk of bias. +2 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2016-11-08

    Inflammasomes, hormesis, and antioxidants in neuroinflammation: Role of NRLP3 in Alzheimer disease

    ✓ Peer-reviewed Inflammation and the immune system Journal of neuroscience research

    Key finding: Recent research suggests that NLRP3 could possibly be used in targeted therapies to alleviate neuroinflammation. +1 more finding

    Full summary, score breakdown and related studies → Original source

  17. 2016-11-07

    Incidence and impact of subclinical epileptiform activity in Alzheimer's disease

    ✓ Peer-reviewed Cognitive tests and assessment Annals of neurology

    Key finding: Extended monitoring detects subclinical epileptiform activity in a substantial proportion of patients with AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  18. 2016-11-07

    End of Life Care: A Scoping Review of Experiences of Advance Care Planning for People with Dementia

    ✓ Peer-reviewed End-of-life care Dementia (London, England)

    Key finding: We conducted a scoping review of studies exploring decisions associated with the EoLC of people with dementia.

    Full summary, score breakdown and related studies → Original source

  19. 2016-11-05

    Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy

    ✓ Peer-reviewed Inflammation and the immune system Brain : a journal of neurology

    Key finding: Neuroinflammatory changes are thought to be major contributors to Alzheimer's disease pathophysiology, even if their precise role still remains largely debated. +3 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2016-11-04

    Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer’s pathology

    ✓ Peer-reviewed Brain scans and imaging Nature Communications

    Key finding: Comparison between cognitively matched normal adult subgroups, delineated according to the amyloid biomarker, revealed abnormal degeneration in basal forebrain, but not entorhinal cortex.

    Full summary, score breakdown and related studies → Original source

  21. 2016-11-04

    Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy

    ✓ Peer-reviewed Brain tissue and pathology Autophagy

    Key finding: Here, for the first time, we have comprehensively evaluated the entire autophagic process specifically in CA1 pyramidal neurons of hippocampus from early and late-stage AD subjects and nondemented controls. +3 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2016-11-03

    Immunotherapy with Aducanumab Restores Calcium Homeostasis in Tg2576 Mice

    ✓ Peer-reviewed Treatments The Journal of Neuroscience

    Key finding: In addition, functional readouts such as calcium overload may be a more useful outcome measure to monitor treatment efficacy in models of Alzheimer's disease compared with amyloid burden alone.

    Full summary, score breakdown and related studies → Original source

  23. 2016-11-03

    Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders

    ✓ Peer-reviewed Risk factors Neurological research

    Key finding: Overproduction of reactive species, notably reactive oxygen (ROS) and nitrogen (RNS) species along with the failure of balance by the body's antioxidant enzyme systems results in destruction of cellular structures, lipids, proteins, and genetic materials such as DNA and RNA.

    Full summary, score breakdown and related studies → Original source

  24. 2016-11-03

    Targeting neuroinflammation in Alzheimer's disease

    ✓ Peer-reviewed Inflammation and the immune system Journal of inflammation research

    Key finding: Alzheimer's disease (AD) accounts for approximately 60%-80% of all dementia cases. +3 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2016-11-03

    Causes of nursing home placement for older people with dementia: a systematic review and meta-analysis

    ✓ Peer-reviewed Caregiving International psychogeriatrics

    Key finding: We recommend focusing on cognitive enhancement strategies, assessment and management of BPSD, and carer education and support to delay nursing home placement. +1 more finding

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →