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Healthy brain connectivity predicts atrophy progression in non-fluent variant of primary progressive aphasia
Mandelli ML, Vilaplana E, Brown JA, Hubbard HI, Binney RJ, Attygalle S, Santos-Santos MA, Miller ZA et al.. Brain : a journal of neurology, 2016-08-06
Topic: Brain proteins, microglia and lab models
Graph theoretical analysis of the speech/language network showed that regions with shorter functional paths to the epicentre exhibited greater longitudinal atrophy. The aslant tract was the white matter pathway connecting these two regions and showed the most significant correlation between fractional anisotropy and white matter longitudinal atrophy changes. This study showed that the pattern of longitudinal atrophy progression in the non-fluent/agrammatic variant of primary progressive aphasia relates to the strength of connectivity in pre-determined functional and structural large-scale speech production networks. These findings support the hypothesis that the spread of neurodegeneration occurs by following specific anatomical and functional neuronal network architectures.
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APA 7th
Mandelli, M. L., Vilaplana, E., Brown, J. A., Hubbard, H. I., Binney, R. J., Attygalle, S., et al. (2016). Healthy brain connectivity predicts atrophy progression in non-fluent variant of primary progressive aphasia. Brain : a journal of neurology. https://doi.org/10.1093/brain/aww195
Vancouver
Mandelli ML, Vilaplana E, Brown JA, Hubbard HI, Binney RJ, Attygalle S, et al. Healthy brain connectivity predicts atrophy progression in non-fluent variant of primary progressive aphasia. Brain : a journal of neurology. 2016. doi:10.1093/brain/aww195. PMID: 27497488.
BibTeX
@article{mandelli2016-27497488,
author = {Mandelli, M. L. and Vilaplana, E. and Brown, J. A. and Hubbard, H. I. and Binney, R. J. and Attygalle, S. and Santos-Santos, M. A. and Miller, Z. A. and others},
title = {{Healthy brain connectivity predicts atrophy progression in non-fluent variant of primary progressive aphasia}},
journal = {Brain : a journal of neurology},
year = {2016},
doi = {10.1093/brain/aww195},
pmid = {27497488},
url = {https://doi.org/10.1093/brain/aww195}
}
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Key findings
- Graph theoretical analysis of the speech/language network showed that regions with shorter functional paths to the epicentre exhibited greater longitudinal atrophy.
- The aslant tract was the white matter pathway connecting these two regions and showed the most significant correlation between fractional anisotropy and white matter longitudinal atrophy changes.
- This study showed that the pattern of longitudinal atrophy progression in the non-fluent/agrammatic variant of primary progressive aphasia relates to the strength of connectivity in pre-determined functional and structural large-scale speech production networks.
- These findings support the hypothesis that the spread of neurodegeneration occurs by following specific anatomical and functional neuronal network architectures.
Why it matters
In the non-fluent/agrammatic variant of primary progressive aphasia, regions with shorter functional paths to the epicentre showed greater longitudinal atrophy, supporting spread of neurodegeneration along network architecture. This concerns how atrophy progresses, not treating, curing, or preventing Alzheimer's disease.
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Study details
- Study designlongitudinal study
- Participants30
- Evidence strengthModerate
How this study scored 62/100
Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Brain : a journal of neurology) |
| Journal's citation record | 4 / 4 | Brain: journal h-index 503 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 1 / 4 | 30 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 142 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 11.8 citations a year over 12 year(s) since 2016 |
| Impact for its field and year | 4 / 6 | Cited 10.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 2 / 4 | Cited 32 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Maria Luisa Gorno‐Tempini: h-index 92 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of California, Berkeley: institution h-index 2,012 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 9 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 27497488) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 62 / 100 | — |
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