Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 15,751–15,775 of 27,380 studies, newest first · page 631 of 1096.
October 2016 13
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2016-10-01
Parkinson disease and cognitive impairment: Five new things
52/100 ✓ Peer-reviewed Prevention trials Neurology. Clinical practice
Key finding: Studies have yielded clues to the etiology and natural history of cognitive impairment in PD, but much remains unclear and effective therapies are needed.
Full summary, score breakdown and related studies → Original source
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2016-10-01
Do "Brain-Training" Programs Work?
36/100 ✓ Peer-reviewed Prevention trials Psychological science in the public interest : a journal of the American Psychological Society
Key finding: How could two teams of scientists examine the same literature and come to conflicting "consensus" views about the effectiveness of brain training? +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-10-01
Heterogeneity in Suspected Non-Alzheimer Disease Pathophysiology Among Clinically Normal Older Individuals
63/100 ✓ Peer-reviewed Disease mechanisms JAMA neurology
Key finding: In this study, clinically normal adults with SNAP did not exhibit evidence of elevated tau levels, which suggests that this biomarker construct does not represent amyloid-independent tauopathy. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-01
Improving Benefits and Integrating Care for Older Medicare Beneficiaries with Physical or Cognitive Impairment
30/100 ✓ Peer-reviewed Health systems and care delivery Issue brief (Commonwealth Fund)
Key finding: Medicare Help at Home—a proposal to add supplemental home- and community-based services—could be financed by income-related cost-sharing, beneficiary monthly premiums of $42, and an incremental payroll tax on employers and employees of 0.4 percent. +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-01
TREM2/DAP12 Signal Elicits Proinflammatory Response in Microglia and Exacerbates Neuropathic Pain
48/100 ✓ Peer-reviewed TREM2 and immune genetics The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: Recent evidence has implicated microglia in neuropathic pain. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-01
Association of GBA Mutations and the E326K Polymorphism With Motor and Cognitive Progression in Parkinson Disease
66/100 ✓ Peer-reviewed Mild cognitive impairment JAMA neurology
Key finding: GBA mutations (β = 4.65; 95% CI, 1.72-7.58; P = .002), E326K (β = 3.42; 95% CI, 0.66-6.17; P = .02), and GBA variants combined as a single group (β = 4.01; 95% CI, 1.95-6.07; P = 1.5 × 10-4) were associated with a more rapid decline in MDS-UPDRS III score. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-01
C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles
54/100 ✓ Peer-reviewed Lewy body dementia Cell
Key finding: Genetic analysis in Drosophila demonstrated the functional relevance of these interactions to DPR toxicity.
Full summary, score breakdown and related studies → Original source
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2016-10-01
A Novel and Intelligent Home Monitoring System for Care Support of Elders with Cognitive Impairment
47/100 ✓ Peer-reviewed Digital health tools Journal of Alzheimer's disease : JAD
Key finding: It has been proved that the proposed system is suitable to support clinicians to reliably drive and evaluate clinical interventions toward quality of life improvement of people with cognitive impairment.
Full summary, score breakdown and related studies → Original source
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2016-10-01
Default Mode Network Functional Connectivity in Early and Late Mild Cognitive Impairment: Results From the Alzheimer's Disease Neuroimaging Initiative
43/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer disease and associated disorders
Key finding: Our results suggest that the breakdown of DMN connectivity may occur in the early stage of MCI. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-01
Longitudinal β-Amyloid Deposition and Hippocampal Volume in Preclinical Alzheimer Disease and Suspected Non-Alzheimer Disease Pathophysiology
64/100 ✓ Peer-reviewed Brain scans and imaging JAMA neurology
Key finding: Among the 174 participants (81 men [46.6%]; 93 women [53.4%]; mean [SD] age, 65.7 [8.9] years), a proportion (14%-17%) of individuals with neurodegeneration alone (SNAP) later demonstrated Aβ+.
Full summary, score breakdown and related studies → Original source
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2016-10-01
Is the Montreal Cognitive Assessment (MoCA) test better suited than the Mini-Mental State Examination (MMSE) in mild cognitive impairment (MCI) detection among people aged over 60? Meta-analysis
54/100 ✓ Peer-reviewed Getting a diagnosis Psychiatria polska
Key finding: MoCA test better meets the criteria for screening tests for the detection of MCI among patients over 60 years of age than MMSE. +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-10-01
A Phase II, Randomized, Double-Blind, Placebo-Controlled Study of Safety, Pharmacokinetics, and Biomarker Results of Subcutaneous Bapineuzumab in Patients with mild to moderate Alzheimer's disease
61/100 ✓ Peer-reviewed Treatments Journal of Alzheimer's disease : JAD
Key finding: Bapineuzumab SC once-monthly did not demonstrate significant treatment difference over placebo on cerebral amyloid signal at one year but was well-tolerated. +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-01
Association of Serum Docosahexaenoic Acid With Cerebral Amyloidosis
54/100 ✓ Peer-reviewed Biomarkers JAMA neurology
Key finding: In this study, serum DHA levels were associated with pathogenesis of cerebral amyloidosis and with preservation of entorhinal and hippocampal volumes. +4 more findings
Full summary, score breakdown and related studies → Original source
September 2016 12
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2016-09-30
Defining imaging biomarker cut points for brain aging and Alzheimer's disease
56/100 ✓ Peer-reviewed Biomarkers Alzheimer s & Dementia
Key finding: The reliable worsening method produced a cut point only for amyloid PET. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-09-30
Medial temporal lobe subregional morphometry using high resolution MRI in Alzheimer's disease
52/100 ✓ Peer-reviewed Long-term cohort studies Neurobiology of aging
Key finding: We applied a novel, automated method for measurement of hippocampal subfields and extrahippocampal MTL cortical regions. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-09-30
Subclinical Thyroid Dysfunction and the Risk of Cognitive Decline: a Meta-Analysis of Prospective Cohort Studies
65/100 ✓ Peer-reviewed Cognitive tests and assessment The Journal of clinical endocrinology and metabolism
Key finding: Although both overt hyper- and hypothyroidism are known to lead to cognitive impairment, data on the association between subclinical thyroid dysfunction and cognitive function are conflicting. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-09-30
Plasma tau in Alzheimer disease
74/100 ✓ Peer-reviewed Getting a diagnosis Neurology
Key finding: Plasma tau partly reflects AD pathology, but the overlap between normal aging and AD is large, especially in patients without dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-09-29
Effects of early life stress on depression, cognitive performance and brain morphology
52/100 ✓ Peer-reviewed Hippocampus size on brain scans Psychological medicine
Key finding: These relationships appear to differ between individuals who do and do not develop depression. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-09-29
Improving Care for High-Cost, High-Need Patients
22/100 ✓ Peer-reviewed Health systems and care delivery Oncology Times
Key finding: And, she noted, data from the 2009-2011 Medical Expenditure Panel Survey have shown that “high-need adults spent more on health care but were less likely to report that the health system works for them.” +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-09-28
Amyloid tracers binding sites in autosomal dominant and sporadic Alzheimer's disease
43/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: 3H-PIB, 3H-florbetaben, 3H-AZD2184, and BTA-1 shared a high- and a varying low-affinity binding site in the frontal cortex of sporadic AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-09-28
Longitudinal brain structural changes in preclinical Alzheimer's disease
59/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: At follow-up, stage 1 subjects showed reduced atrophy rates in medial frontal areas and precuneus compared to stage 0 subjects, whereas stage 2/3 subjects presented accelerated atrophy in medial temporal structures. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-09-28
Does neuroinflammation drive the relationship between tau hyperphosphorylation and dementia development following traumatic brain injury?
38/100 ✓ Peer-reviewed Disease mechanisms Brain, behavior, and immunity
Key finding: A history of traumatic brain injury (TBI) is linked to an increased risk for the later development of dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-09-28
Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice
36/100 ✓ Peer-reviewed Disease mechanisms The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: We found that these brain ApoE knock-out (bEKO) mice had synaptic loss and dysfunction similar to that of ApoE KO mice; however, the bEKO mice did not have the learning and memory impairment observed in ApoE KO mice. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-09-27
Unrecognized Cognitive Impairment and Its Effect on Heart Failure Readmissions of Elderly Adults
55/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society
Key finding: Cognitive impairment, which is frequently undocumented, may indicate greater risk of readmission for individuals with HF than those without. +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-09-27
Exosome secretion is a key pathway for clearance of pathological TDP-43
50/100 ✓ Peer-reviewed Lewy body dementia Brain : a journal of neurology
Key finding: Exposure of Neuro2a cells to exosomes from amyotrophic lateral sclerosis brain, but not from control brain, caused cytoplasmic redistribution of TDP-43, suggesting that secreted exosomes might contribute to propagation of TDP-43 proteinopathy. +1 more finding
Full summary, score breakdown and related studies → Original source
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