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Subclinical Thyroid Dysfunction and the Risk of Cognitive Decline: a Meta-Analysis of Prospective Cohort Studies
Rieben C, Segna D, da Costa BR, Collet TH, Chaker L, Aubert CE, Baumgartner C, Almeida OP et al.. The Journal of clinical endocrinology and metabolism, 2016-09-30
Topic: Risk, prevention and care in population studies
Context Although both overt hyper- and hypothyroidism are known to lead to cognitive impairment, data on the association between subclinical thyroid dysfunction and cognitive function are conflicting. Objective This study sought to determine the risk of dementia and cognitive decline associated with subclinical thyroid dysfunction among prospective cohorts. Data sources We searched in MEDLINE and EMBASE from inception until November 2014.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Rieben, C., Segna, D., da Costa, B. R., Collet, T. H., Chaker, L., Aubert, C. E., et al. (2016). Subclinical Thyroid Dysfunction and the Risk of Cognitive Decline: a Meta-Analysis of Prospective Cohort Studies. The Journal of clinical endocrinology and metabolism. https://doi.org/10.1210/jc.2016-2129
Vancouver
Rieben C, Segna D, da Costa BR, Collet TH, Chaker L, Aubert CE, et al. Subclinical Thyroid Dysfunction and the Risk of Cognitive Decline: a Meta-Analysis of Prospective Cohort Studies. The Journal of clinical endocrinology and metabolism. 2016. doi:10.1210/jc.2016-2129. PMID: 27689250.
BibTeX
@article{rieben2016-27689250,
author = {Rieben, C. and Segna, D. and da Costa, B. R. and Collet, T. H. and Chaker, L. and Aubert, C. E. and Baumgartner, C. and Almeida, O. P. and others},
title = {{Subclinical Thyroid Dysfunction and the Risk of Cognitive Decline: a Meta-Analysis of Prospective Cohort Studies}},
journal = {The Journal of clinical endocrinology and metabolism},
year = {2016},
doi = {10.1210/jc.2016-2129},
pmid = {27689250},
url = {https://doi.org/10.1210/jc.2016-2129}
}
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Key findings
- Objective This study sought to determine the risk of dementia and cognitive decline associated with subclinical thyroid dysfunction among prospective cohorts.
- Data sources We searched in MEDLINE and EMBASE from inception until November 2014.
- Study selection Two physicians identified prospective cohorts that assessed thyroid function and cognitive outcomes (dementia; Mini-Mental State Examination [MMSE]).
- Data extraction Data were extracted by one reviewer following standardized protocols and verified by a second reviewer.
Why it matters
This meta-analysis of prospective cohort studies examined whether subclinical thyroid dysfunction is linked to dementia and cognitive decline. The available text does not report the direction or significance of any association found.
Study details
- Participants6,410
- Effect size0.0%
- Evidence strengthLow
How this study scored 65/100
Published in a peer-reviewed journal, and it is a meta-analysis pooling many studies.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The Journal of clinical endocrinology and metabolism) |
| Journal's citation record | 3 / 4 | The Journal of Clinical Endocrinology & Metabolism: journal h-index 490 (OpenAlex, 2026-10-29) |
| Study design | 12 / 12 | A meta-analysis pooling many studies (from PubMed type “Meta-Analysis”) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 3 / 4 | 6,410 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | A review of other studies — randomisation is not credited here |
| Times cited | 5 / 7 | Cited 175 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 14.6 citations a year over 12 year(s) since 2016 |
| Impact for its field and year | 2 / 6 | Cited 2.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 2 / 4 | Cited 37 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Nicolas Rodondi: h-index 78 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Cambridge: institution h-index 1,973 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 16 institution(s) in 5 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 27689250) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 65 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1210/jc.2016-2129
- PubMed: 27689250
- Original source →
- Free full text: The Journal of Clinical Endocrinology & Metabolism →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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