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Updating the Evidence on the Association between Serum Cholesterol and Risk of Late-Life Dementia: Review and Meta-Analysis
Anstey KJ, Ashby-Mitchell K, Peters R.. Journal of Alzheimer's disease : JAD, 2017-01-01
Topic: Risk, prevention and care in population studies
Background Cohort studies have reported that midlife high total serum cholesterol (TC) is associated with increased risk of Alzheimer's disease (AD) in late-life but findings have been based on few studies and previous reviews have been limited by a lack of compatible data. Objective We synthesized all high quality data from cohort studies reporting on the association between total serum cholesterol measured and late-life cognitive outcomes including Alzheimer's disease (AD), vascular dementia (VaD), any dementia, mild cognitive impairment (MCI), and cognitive decline. Methods The literature was searched up to October 2016 using a registered protocol.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Anstey, K. J., Ashby-Mitchell, K., & Peters, R. (2017). Updating the Evidence on the Association between Serum Cholesterol and Risk of Late-Life Dementia: Review and Meta-Analysis. Journal of Alzheimer's disease : JAD. https://doi.org/10.3233/jad-160826
Vancouver
Anstey KJ, Ashby-Mitchell K, Peters R. Updating the Evidence on the Association between Serum Cholesterol and Risk of Late-Life Dementia: Review and Meta-Analysis. Journal of Alzheimer's disease : JAD. 2017. doi:10.3233/jad-160826. PMID: 27911314.
BibTeX
@article{anstey2017-27911314,
author = {Anstey, K. J. and Ashby-Mitchell, K. and Peters, R.},
title = {{Updating the Evidence on the Association between Serum Cholesterol and Risk of Late-Life Dementia: Review and Meta-Analysis}},
journal = {Journal of Alzheimer's disease : JAD},
year = {2017},
doi = {10.3233/jad-160826},
pmid = {27911314},
url = {https://doi.org/10.3233/jad-160826}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Objective We synthesized all high quality data from cohort studies reporting on the association between total serum cholesterol measured and late-life cognitive outcomes including Alzheimer's disease (AD), vascular dementia (VaD), any dementia, mild cognitive impairment (MCI), and cognitive decline.
- Methods The literature was searched up to October 2016 using a registered protocol.
- Thirty-four articles meeting study criteria were identified.
- Seventeen studies published from 1996 to 2014, including 23,338 participants were included in meta-analyses.
Why it matters
This review and meta-analysis synthesized cohort study data on the association between total serum cholesterol and late-life cognitive outcomes including Alzheimer's disease, vascular dementia, any dementia, mild cognitive impairment, and cognitive decline. It examines a risk association only and does not test any treatment, cure, or prevention for Alzheimer's disease.
Study details
- Study designmeta-analysis
- Participants23,338
- Evidence strengthHigh
How this study scored 73/100
Published in a peer-reviewed journal, and it is a meta-analysis pooling many studies. Scored zero for effect reported because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer's disease : JAD) |
| Journal's citation record | 2 / 4 | Journal of Alzheimer s Disease: journal h-index 218 (OpenAlex, 2026-10-29) |
| Study design | 12 / 12 | A meta-analysis pooling many studies |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2017 — within 10 year(s) of the newest study here |
| Sample size | 4 / 4 | 23,338 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | A review of other studies — randomisation is not credited here |
| Times cited | 6 / 7 | Cited 362 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 32.9 citations a year over 11 year(s) since 2017 |
| Impact for its field and year | 4 / 6 | Cited 15.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 23 other studies in this library |
| Still being cited | 3 / 4 | Cited 109 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Ruth K Peters: h-index 72 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Australian National University: institution h-index 1,088 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 27911314) |
| Free to read | 2 / 2 | Free to read |
| Total | 73 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.3233/jad-160826
- PubMed: 27911314
- Original source →
- Free full text: Journal of Alzheimer s Disease →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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