Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 15,676–15,700 of 27,380 studies, newest first · page 628 of 1096.
November 2016 1
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2016-11-01
Chronic low-dose-rate ionising radiation affects the hippocampal phosphoproteome in the ApoE-/- Alzheimer's mouse model
39/100 ✓ Peer-reviewed Biomarkers Oncotarget
Key finding: Accruing data indicate that radiation-induced consequences resemble pathologies of neurodegenerative diseases such as Alzheimer´s. +3 more findings
Full summary, score breakdown and related studies → Original source
October 2016 24
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2016-10-31
Impact of intermittent fasting on health and disease processes
45/100 ✓ Peer-reviewed Risk factors Ageing research reviews
Key finding: Overconsumption of food with such eating patterns often leads to metabolic morbidities (insulin resistance, excessive accumulation of visceral fat, etc.), particularly when associated with a sedentary lifestyle. +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-29
Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS)
45/100 ✓ Peer-reviewed Risk factors Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Key finding: Level C recommendation (possible efficacy) is proposed for anodal tDCS of the left M1 (or contralateral to pain side, with right orbitofrontal cathode) in chronic lower limb neuropathic pain secondary to spinal cord lesion. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-28
Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy
55/100 ✓ Peer-reviewed Inflammation and the immune system Acta neuropathologica communications
Key finding: Here we set out to determine the relationship between RHI exposure, neuroinflammation, and the development of hyperphosphorylated tau (ptau) pathology and dementia risk in CTE. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-28
Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial impairment, and neurovascular uncoupling in aging
50/100 ✓ Peer-reviewed Inflammation and the immune system American journal of physiology. Heart and circulatory physiology
Key finding: Understanding and targeting the age-related pathophysiological mechanisms that underlie vascular contributions to cognitive impairment and dementia (VCID) are expected to have a major role in preserving brain health in older individuals. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-28
Concomitant AD pathology affects clinical manifestation and survival in dementia with Lewy bodies
54/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of neurology, neurosurgery, and psychiatry
Key finding: We selected 111 patients with probable DLB and CSF available from the Amsterdam Dementia Cohort. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-27
Amyloid beta modulators and neuroprotection in Alzheimer's disease: a critical appraisal
39/100 ✓ Peer-reviewed Disease mechanisms Drug discovery today
Key finding: The Aβ formed as a result of abnormal APP processing induces phosphorylated tau and activates glycogen synthase kinase-3β (GSK3β) and cyclin-dependent kinase-5 (CDK5).
Full summary, score breakdown and related studies → Original source
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2016-10-27
A multicenter, randomized, placebo-controlled trial for cilostazol in patients with mild cognitive impairment: The COMCID study protocol
64/100 ✓ Peer-reviewed Drug development Alzheimer's & dementia (New York, N. Y.)
Key finding: The COMCID trial will identify the therapeutic potential of cilostazol. +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-10-27
Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia
43/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: The recommendations were developed by a multidisciplinary working group based on the available evidence and consensus from focused discussions for (i) identification of Alzheimer's disease (AD) as the cause of dementia, (ii) prediction of rate of decline, (iii) cost-effectiveness, and (iv) interpretation of results. +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-10-27
Short-term association between environmental factors and hospital admissions due to dementia in Madrid
53/100 ✓ Peer-reviewed Risk factors Environmental research
Key finding: During the study period, there were 1175 DDE hospital admissions.
Full summary, score breakdown and related studies → Original source
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2016-10-27
Glucagon-like Peptide-1 and the Central/Peripheral Nervous System: Crosstalk in Diabetes
38/100 ✓ Peer-reviewed Drug development Trends in endocrinology and metabolism: TEM
Key finding: GLP-1 is also important in the regulation of neurologic and cognitive functions. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-27
[18 F]AV-1451 tau positron emission tomography in progressive supranuclear palsy
38/100 ✓ Peer-reviewed Disease mechanisms Movement disorders : official journal of the Movement Disorder Society
Key finding: Progressive supranuclear palsy is associated with an elevated [ 18 F]AV-1451 signal in a characteristic and distinct regional pattern that correlates with disease severity and differs from the patterns observed in Alzheimer's dementia. © 2016 International Parkinson and Movement Disorder Society. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-27
Recommendations for cerebrospinal fluid Alzheimer's disease biomarkers in the diagnostic evaluation of mild cognitive impairment
51/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: The recommendations were developed by a multidisciplinary working group and based on the available evidence and consensus from focused group discussions for 1) prediction of clinical progression to Alzheimer's disease (AD) dementia, 2) cost-effectiveness, 3) interpretation of results, and 4) patient counseling. +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-10-26
Ginkgolic Acid Protects against Aβ-Induced Synaptic Dysfunction in the Hippocampus
38/100 ✓ Peer-reviewed Disease mechanisms Frontiers in pharmacology
Key finding: Data obtained indicate that GA exerts neuroprotective effects against Aβ-induced impairment of neurotransmitter release and synaptic plasticity.
Full summary, score breakdown and related studies → Original source
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2016-10-26
Patterns of health service use in community living older adults with dementia and comorbid conditions: a population-based retrospective cohort study in Ontario, Canada
55/100 ✓ Peer-reviewed Digital health tools BMC geriatrics
Key finding: Comorbidities in community-living older adults with dementia are common and account for a substantial proportion of health service use and costs in this population. +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-10-26
Family caregivers' conceptualisation of quality end-of-life care for people with dementia: A qualitative study
41/100 ✓ Peer-reviewed End-of-life care Palliative medicine
Key finding: End-of-life care for people with dementia does not differ from care throughout the dementia trajectory. +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-10-26
Polyubiquitinylation Profile in Down Syndrome Brain Before and After the Development of Alzheimer Neuropathology
43/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Antioxidants & redox signaling
Key finding: Disturbance of the polyubiquitinylation machinery may be a key feature of aging and neurodegeneration. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-25
Development of a caregiver-reported measure to support systematic assessment of people with dementia in long-term care: The Integrated Palliative care Outcome Scale for Dementia
45/100 ✓ Peer-reviewed End-of-life care Palliative medicine
Key finding: Integrated Palliative care Outcome Scale for Dementia is a comprehensive and acceptable caregiver-reported measure to detect symptoms and problems in dementia.
Full summary, score breakdown and related studies → Original source
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2016-10-25
Decision-making on behalf of people living with dementia: how do surrogate decision-makers decide?
38/100 ✓ Peer-reviewed End-of-life care Journal of medical ethics
Key finding: Surrogate decision-making on behalf of a person living with dementia is often a difficult process. +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-10-25
Nuclear but not mitochondrial-encoded oxidative phosphorylation genes are altered in aging, mild cognitive impairment, and Alzheimer's disease
43/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Our findings suggest that restoration of the expression of nuclear-encoded OXPHOS genes in aging could be a viable strategy for blunting AD progression. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-25
Clinicopathological features of adult-onset neuronal intranuclear inclusion disease
61/100 ✓ Peer-reviewed Getting a diagnosis Brain : a journal of neurology
Key finding: Our study suggested that the prevalence rate of adult-onset NIID may be higher than previously thought, and that NIID may be underdiagnosed.
Full summary, score breakdown and related studies → Original source
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2016-10-24
REAC technology modifies pathological neuroinflammation and motor behaviour in an Alzheimer's disease mouse model
38/100 ✓ Peer-reviewed Biomarkers Scientific reports
Key finding: Here, it is demonstrated that the Radio Electric Asymmetric Conveyer (REAC), an innovative technology platform for neuro- and bio-modulation, used according to the neuro-regenerative protocol (RGN-N), significantly increases astroglial reaction around the amyloid plaques in an AD mouse model, as evaluated by GFAP-immunoreactivity, and reduces microglia-associated neuroinflammation markers, as evaluated by Iba1-immunoreactivity and mRNA expression level of inflammatory cytokines TREM. +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-10-21
Cognitive Function in Low-Income and Low-Literacy Settings: Validation of the Tablet-Based Oxford Cognitive Screen in the Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in South Africa (HAALSI)
48/100 ✓ Peer-reviewed Cognitive tests and assessment The journals of gerontology. Series B, Psychological sciences and social sciences
Key finding: The OCS-Plus represents a major methodological advance in dementia studies in LMICs, and enhances understanding of cognitive aging.
Full summary, score breakdown and related studies → Original source
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2016-10-21
Reliability and Validity of the Resistiveness to Care Scale Among Cognitively Impaired Older Adults
66/100 ✓ Peer-reviewed End-of-life care Journal of the American Medical Directors Association
Key finding: The findings support the reliability and validity of the Resistiveness to Care Scale for use with older adults with dementia in nursing home settings. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-21
Gait disorders in adults and the elderly : A clinical guide
50/100 ✓ Peer-reviewed How common it is Wiener klinische Wochenschrift
Key finding: Gait disorders lead to a loss of personal freedom, falls and injuries and result in a marked reduction in the quality of life. +1 more finding
Full summary, score breakdown and related studies → Original source
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