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54/100

✓ Peer-reviewed alzhub usefulness score 54 out of 100. Getting a diagnosis

Topic: Brain proteins, microglia and lab models

Neurogenic orthostatic hypotension (nOH) is common in patients with neurodegenerative disorders such as Parkinson's disease, multiple system atrophy, pure autonomic failure, dementia with Lewy bodies, and peripheral neuropathies including amyloid or diabetic neuropathy. Due to the frequency of nOH in the aging population, clinicians need to be well informed about its diagnosis and management. To date, studies of nOH have used different outcome measures and various methods of diagnosis, thereby preventing the generation of evidence-based guidelines to direct clinicians towards 'best practices' when treating patients with nOH and associated supine hypertension. To address these issues, the American Autonomic Society and the National Parkinson Foundation initiated a project to develop a statement of recommendations beginning with a consensus panel meeting in Boston on November 7, 2015, with continued communications and contributions to the recommendations through October of 2016. This paper summarizes the panel members' discussions held during the initial meeting along with continued deliberations among the panel members and provides essential recommendations based upon best available evidence as well as expert opinion for the (1) screening, (2) diagnosis, (3) treatment of nOH, and (4) diagnosis and treatment of associated supine hypertension.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Gibbons, C. H., Schmidt, P., Biaggioni, I., Frazier-Mills, C., Freeman, R., Isaacson, S., et al. (2017). The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertension. Journal of neurology. https://doi.org/10.1007/s00415-016-8375-x

Vancouver

Gibbons CH, Schmidt P, Biaggioni I, Frazier-Mills C, Freeman R, Isaacson S, et al. The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertension. Journal of neurology. 2017. doi:10.1007/s00415-016-8375-x. PMID: 28050656.

BibTeX

@article{gibbons2017-28050656,
  author  = {Gibbons, C. H. and Schmidt, P. and Biaggioni, I. and Frazier-Mills, C. and Freeman, R. and Isaacson, S. and Karabin, B. and Kuritzky, L. and others},
  title   = {{The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertension}},
  journal = {Journal of neurology},
  year    = {2017},
  doi     = {10.1007/s00415-016-8375-x},
  pmid    = {28050656},
  url     = {https://doi.org/10.1007/s00415-016-8375-x}
}

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Key findings

Neurogenic orthostatic hypotension (nOH) is common in patients with neurodegenerative disorders such as Parkinson's disease, multiple system atrophy, pure autonomic failure, dementia with Lewy bodies, and peripheral neuropathies including amyloid or diabetic neuropathy.
Due to the frequency of nOH in the aging population, clinicians need to be well informed about its diagnosis and management.
To date, studies of nOH have used different outcome measures and various methods of diagnosis, thereby preventing the generation of evidence-based guidelines to direct clinicians towards 'best practices' when treating patients with nOH and associated supine hypertension.
To address these issues, the American Autonomic Society and the National Parkinson Foundation initiated a project to develop a statement of recommendations beginning with a consensus panel meeting in Boston on November 7, 2015, with continued communications and contributions to the recommendations through October of 2016.
This paper summarizes the panel members' discussions held during the initial meeting along with continued deliberations among the panel members and provides essential recommendations based upon best available evidence as well as expert opinion for the (1) screening, (2) diagnosis, (3) treatment of nOH, and (4) diagnosis and treatment of associated supine hypertension.

Why it matters

This consensus panel paper provides recommendations for screening, diagnosing, and treating neurogenic orthostatic hypotension and associated supine hypertension, conditions common in several neurodegenerative disorders including dementia with Lewy bodies. It is a set of expert recommendations rather than a study of a treatment that changes the course of Alzheimer's disease.

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Study details

Evidence strengthLow

How this study scored 54/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of neurology)
Journal's citation record	2 / 4	Journal of Neurology: journal h-index 208 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2017 — within 10 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	6 / 7	Cited 453 times (OpenAlex, 2026-10-10)
Citations per year	4 / 5	41.2 citations a year over 11 year(s) since 2017
Impact for its field and year	6 / 6	Cited 40.3× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	3 / 4	Cited 136 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Horacio Kaufmann: h-index 71 (OpenAlex, whole career)
Institution's track record	3 / 3	Harvard University: institution h-index 3,235 (OpenAlex)
Multi-centre collaboration	3 / 3	OpenAlex lists 14 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 28050656)
Free to read	2 / 2	Free to read
Total	54 / 100	—

What each of these 20 components measures, and what this score is not →

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