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Extracellular matrix inflammation in vascular cognitive impairment and dementia
Rosenberg GA.. Clinical science (London, England : 1979), 2017-03-01
Topic: Brain proteins, microglia and lab models
Vascular cognitive impairment and dementia (VCID) include a wide spectrum of chronic manifestations of vascular disease related to large vessel strokes and small vessel disease (SVD). Lacunar strokes and white matter (WM) injury are consequences of SVD. The main vascular risk factor for SVD is brain hypoperfusion from cerebral blood vessel narrowing due to chronic hypertension.
Key findings
- Lacunar strokes and white matter (WM) injury are consequences of SVD.
- The main vascular risk factor for SVD is brain hypoperfusion from cerebral blood vessel narrowing due to chronic hypertension.
- The hypoperfusion leads to activation and degeneration of astrocytes with the resulting fibrosis of the extracellular matrix (ECM).
- Elasticity is lost in fibrotic cerebral vessels, reducing the response of stiffened blood vessels in times of increased metabolic need.
Why it matters
This review describes how brain hypoperfusion from chronic hypertension leads to activation and degeneration of astrocytes with fibrosis of the extracellular matrix in vascular cognitive impairment and dementia. It concerns vascular cognitive impairment and dementia and does not report a treatment or cure for Alzheimer's disease.
Study details
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Clinical science (London, England : 1979)) |
| Journal's citation record | 2 / 4 | Clinical Science: journal h-index 212 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2017 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 185 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 16.8 citations a year over 11 year(s) since 2017 |
| Impact for its field and year | 3 / 6 | Cited 7.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 5 other studies in this library |
| Still being cited | 2 / 4 | Cited 48 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Gary A. Rosenberg: h-index 80 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of New Mexico: institution h-index 845 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 28265034) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 43 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Rosenberg, G. A. (2017). Extracellular matrix inflammation in vascular cognitive impairment and dementia. Clinical science (London, England : 1979). https://doi.org/10.1042/cs20160604
Vancouver
Rosenberg GA. Extracellular matrix inflammation in vascular cognitive impairment and dementia. Clinical science (London, England : 1979). 2017. doi:10.1042/cs20160604. PMID: 28265034.
BibTeX
@article{rosenberg2017-28265034,
author = {Rosenberg, G. A.},
title = {{Extracellular matrix inflammation in vascular cognitive impairment and dementia}},
journal = {Clinical science (London, England : 1979)},
year = {2017},
doi = {10.1042/cs20160604},
pmid = {28265034},
url = {https://doi.org/10.1042/cs20160604}
}
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