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Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial
Sandrine Andrieu, Sophie Guyonnet, Nicola Coley, Christelle Cantet, Marc Bonnefoy, Serge Bordes, Lawrence Bories, Marie-Noëlle Cufi, THIERRY F. DANTOINE, Jean‐François Dartigues, Françoise Desclaux, Audrey Gabelle, Yannick Gasnier, Alain Pesce, Kristel Sudres, Jacques Touchon, Philippe Henri Robert, Olivier Rouaud, Philippe Legrand, Pierre Payoux, Jean-Paul Caubère, Michael W. Weiner, Isabelle Carrié, Pierre-Jean Ousset, Bruno J. Vellas, Bruno Vellas, Sophie Guyonnet, Isabelle Carrié, Lauréane Brigitte, Catherine Faisant, Françoise Lala, Julien Delrieu, Hélène Villars, Emeline Combrouze, Carole Badufle, Audrey Zueras, Sandrine Andrieu, Christelle Cantet, Christophe Morin, Gabor Abellán van Kan, Charlotte Dupuy, Yves Rolland, Céline Caillaud, Pierre-Jean Ousset, Bertrand Fougère, Sherry L. Willis, Sylvie Belleville, Brigitte Gilbert, Francine S. Fontaine, Jean‐François Dartigues, Isabelle Marcet, Fleur Delva, Alexandra Foubert, Sandrine Cerda, Marie Noëlle-Cuffi, Corinne Costes, Olivier Rouaud, Patrick Manckoundia, Valérie Quipourt, Sophie Marilier, Evelyne Franon, Lawrence Bories, Marie-Laure Pader, Marie-France Basset, Bruno Lapoujade, Valérie Faure, Michael Li, Yung Tong, Christine Malick-Loiseau, Evelyne Cazaban-Campistron, Françoise Desclaux, Colette Blatge, Thierry Dantoine, Cécile Laubarie-Mouret, Isabelle Saulnier, Jean-Pierre Clément, Marie-Agnès Picat, Laurence Bernard‐Bourzeix, Stéphanie Willebois, Iléana Désormais, Noëlle Cardinaud, Marc Bonnefoy, Pierre Livet, Pascale Rebaudet, Claire Gédéon, Catherine Burdet, Flavien Terracol, Alain Pesce, Stéphanie Roth, Sylvie Chaillou, Sandrine Louchart, Kristel Sudres, Nicolas Lebrun, Nadège Barro-Belaygues, Jacques Touchon, Karim Bennys, Audrey Gabelle, Aurélia Romano, Lynda Touati, Cécilia Marelli, Cécile Pays, Philippe Henri Robert, Franck Le Duff, Claire Gervais, Sebastien Gonfrier, Yannick Gasnier, Serge Bordes, Danièle Begorre, Christian Carpuat, Khaled Khales, Jean-François Lefebvre, Samira Misbah El Idrissi, Pierre Skolil, Jean-Pierre Salles, Carole Dufouil, Stéphane Lehéricy, Marie Chupin, Jean‐François Mangin, Ali Bouhayia, Michèle Allard, Frédéric Ricolfi, Dominique Dubois, Marie Paule, B. Martel, François Cotton, Alain Bonafé, S. Chanalet, Françoise Hugon, Fabrice Bonneville, Christophe Cognard, François Chollet, Pierre Payoux, Thierry Voisin, Sophie Peiffer, Anne Hitzel, Michèle Allard, Michel Zanca, Jacques Monteil, Jacques Darcourt, Laurent Molinier, Hélène Derumeaux, Nadège Costa, Christian Vincent, Bertrand Perret, Claire Vinel, Pascale Olivier. The Lancet Neurology, 2017-03-27
Topic: Brain proteins, microglia and lab models
Researchers conducted a trial to test the effect of omega 3 polyunsaturated fatty acid supplementation and a multidomain intervention, alone or in combination, compared with placebo, on cognitive decline in elderly adults with memory complaints. The study evaluated whether these interventions could prevent or delay cognitive impairment. Ultimately, the results showed no significant effects of the interventions on cognitive decline over the duration of the trial.
Key findings
- There were no significant differences in 3-year cognitive decline between any of the three intervention groups and the placebo group.
- The interventions did not raise any safety concerns and there were no differences between groups in serious or other adverse events.
- The multidomain intervention and polyunsaturated fatty acids, either alone or in combination, had no significant effects on cognitive decline over 3 years in elderly people with memory complaints.
Why it matters
A randomised, placebo-controlled trial (MAPT) testing long-term omega 3 fatty acid supplements, with or without a multidomain intervention, on thinking skills in older adults with memory complaints.
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How this study scored 59/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported and studied in people because the record does not state it. We have no data on strength of evidence, so that was left out: it earned 56 of the 95 points we could judge it on, which is 59 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (The Lancet Neurology) |
| Journal's citation record | 3 / 4 | The Lancet Neurology: journal h-index 457 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | — / 5 | No evidence rating recorded — left out of this score |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2017 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 2 / 2 | Randomised and blinded or placebo-controlled (as stated in the record) |
| Times cited | 6 / 7 | Cited 836 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 76.0 citations a year over 11 year(s) since 2017 |
| Impact for its field and year | 6 / 6 | Cited 56.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 4 / 4 | Cited 251 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Cécilia Marelli: h-index 42 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Inserm: institution h-index 1,988 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 48 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 28359749) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 56 / 95 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 56 of the 95 points we could judge it on is 59 out of 100. |
| Total | 59 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 127 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Andrieu, S., Guyonnet, S., Coley, N., Cantet, C., Bonnefoy, M., Bordes, S., et al. (2017). Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial. The Lancet Neurology. https://doi.org/10.1016/s1474-4422(17)30040-6
Vancouver
Andrieu S, Guyonnet S, Coley N, Cantet C, Bonnefoy M, Bordes S, et al. Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial. The Lancet Neurology. 2017. doi:10.1016/s1474-4422(17)30040-6. PMID: 28359749.
BibTeX
@article{andrieu2017-28359749,
author = {Andrieu, Sandrine and Guyonnet, Sophie and Coley, Nicola and Cantet, Christelle and Bonnefoy, Marc and Bordes, Serge and Bories, Lawrence and Cufi, Marie-Noëlle and DANTOINE, THIERRY F. and Dartigues, Jean‐François and Desclaux, Françoise and Gabelle, Audrey and Gasnier, Yannick and Pesce, Alain and Sudres, Kristel and Touchon, Jacques and Robert, Philippe Henri and Rouaud, Olivier and Legrand, Philippe and Payoux, Pierre and Caubère, Jean-Paul and Weiner, Michael W. and Carrié, Isabelle and Ousset, Pierre-Jean and Vellas, Bruno J. and Vellas, Bruno and Brigitte, Lauréane and Faisant, Catherine and Lala, Françoise and Delrieu, Julien and Villars, Hélène and Combrouze, Emeline and Badufle, Carole and Zueras, Audrey and Morin, Christophe and van Kan, Gabor Abellán and Dupuy, Charlotte and Rolland, Yves and Caillaud, Céline and Fougère, Bertrand and Willis, Sherry L. and Belleville, Sylvie and Gilbert, Brigitte and Fontaine, Francine S. and Marcet, Isabelle and Delva, Fleur and Foubert, Alexandra and Cerda, Sandrine and Noëlle-Cuffi, Marie and Costes, Corinne and Manckoundia, Patrick and Quipourt, Valérie and Marilier, Sophie and Franon, Evelyne and Pader, Marie-Laure and Basset, Marie-France and Lapoujade, Bruno and Faure, Valérie and Li, Michael and Tong, Yung and Malick-Loiseau, Christine and Cazaban-Campistron, Evelyne and Blatge, Colette and Dantoine, Thierry and Laubarie-Mouret, Cécile and Saulnier, Isabelle and Clément, Jean-Pierre and Picat, Marie-Agnès and Bernard‐Bourzeix, Laurence and Willebois, Stéphanie and Désormais, Iléana and Cardinaud, Noëlle and Livet, Pierre and Rebaudet, Pascale and Gédéon, Claire and Burdet, Catherine and Terracol, Flavien and Roth, Stéphanie and Chaillou, Sylvie and Louchart, Sandrine and Lebrun, Nicolas and Barro-Belaygues, Nadège and Bennys, Karim and Romano, Aurélia and Touati, Lynda and Marelli, Cécilia and Pays, Cécile and Le Duff, Franck and Gervais, Claire and Gonfrier, Sebastien and Begorre, Danièle and Carpuat, Christian and Khales, Khaled and Lefebvre, Jean-François and El Idrissi, Samira Misbah and Skolil, Pierre and Salles, Jean-Pierre and Dufouil, Carole and Lehéricy, Stéphane and Chupin, Marie and Mangin, Jean‐François and Bouhayia, Ali and Allard, Michèle and Ricolfi, Frédéric and Dubois, Dominique and Paule, Marie and Martel, B. and Cotton, François and Bonafé, Alain and Chanalet, S. and Hugon, Françoise and Bonneville, Fabrice and Cognard, Christophe and Chollet, François and Voisin, Thierry and Peiffer, Sophie and Hitzel, Anne and Zanca, Michel and Monteil, Jacques and Darcourt, Jacques and Molinier, Laurent and Derumeaux, Hélène and Costa, Nadège and Vincent, Christian and Perret, Bertrand and Vinel, Claire and Olivier, Pascale},
title = {{Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial}},
journal = {The Lancet Neurology},
year = {2017},
doi = {10.1016/s1474-4422(17)30040-6},
pmid = {28359749},
url = {https://doi.org/10.1016/s1474-4422(17)30040-6}
}
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