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Feasibility of in vivo 18F-florbetaben PET/MR imaging of human carotid amyloid-β
Jan Bucerius, Henryk Barthel, Solveig Tiepolt, Peter Werner, Judith C Sluimer, Joachim E Wildberger, Marianne Patt, Swen Hesse et al.. European journal of nuclear medicine and molecular imaging, 2017-03-21
Topic: Plasma and spinal-fluid biomarkers
18F-Florbetaben uptake was clearly visualized in the carotid arteries. Values of meanTBRmax corrected for the blood pool activity of the tracer showed specific 18F-florbetaben uptake in the carotid wall. Male gender was associated with carotid 18F-florbetaben uptake in the univariate analysis, and was found to be an independent predictor of 18F-florbetaben uptake in the multivariate regression analysis (standardized regression coefficient β = 0.407, p = 0.009). Carotid 18F-florbetaben meanTBRmax in patients with a positive cerebral Aβ scan did not differ from that in patients without cerebral Aβ deposits. Specific 18F-florbetaben uptake in human carotid arteries was detected. Male gender was identified as an independent clinical risk factor. Therefore, 18F-florbetaben PET/MRI might provide new insights into the pathophysiological process in atherosclerosis.
Key findings
- 18F-Florbetaben uptake was clearly visualized in the carotid arteries.
- Values of meanTBRmax corrected for the blood pool activity of the tracer showed specific 18F-florbetaben uptake in the carotid wall.
- Male gender was associated with carotid 18F-florbetaben uptake in the univariate analysis, and was found to be an independent predictor of 18F-florbetaben uptake in the multivariate regression analysis (standardized regression coefficient β = 0.407, p = 0.009).
- Carotid 18F-florbetaben meanTBRmax in patients with a positive cerebral Aβ scan did not differ from that in patients without cerebral Aβ deposits.
- Specific 18F-florbetaben uptake in human carotid arteries was detected.
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Study details
- Evidence strengthLow
How this study scored 39/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 22 of the 56 points we could judge it on, which is 39 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (European journal of nuclear medicine and molecular imaging) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2017 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 28321471) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 22 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 22 of the 56 points we could judge it on is 39 out of 100. |
| Total | 39 / 100 | — |
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
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APA 7th
Bucerius, J., Barthel, H., Tiepolt, S., Werner, P., Sluimer, J. C., Wildberger, J. E., et al. (2017). Feasibility of in vivo 18F-florbetaben PET/MR imaging of human carotid amyloid-β. European journal of nuclear medicine and molecular imaging. https://doi.org/10.1007/s00259-017-3651-2
Vancouver
Bucerius J, Barthel H, Tiepolt S, Werner P, Sluimer JC, Wildberger JE, et al. Feasibility of in vivo 18F-florbetaben PET/MR imaging of human carotid amyloid-β. European journal of nuclear medicine and molecular imaging. 2017. doi:10.1007/s00259-017-3651-2. PMID: 28321471.
BibTeX
@article{bucerius2017-28321471,
author = {Bucerius, Jan and Barthel, Henryk and Tiepolt, Solveig and Werner, Peter and Sluimer, Judith C and Wildberger, Joachim E and Patt, Marianne and Hesse, Swen and others},
title = {{Feasibility of in vivo 18F-florbetaben PET/MR imaging of human carotid amyloid-β}},
journal = {European journal of nuclear medicine and molecular imaging},
year = {2017},
doi = {10.1007/s00259-017-3651-2},
pmid = {28321471},
url = {https://doi.org/10.1007/s00259-017-3651-2}
}
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