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39/100

✓ Peer-reviewed alzhub usefulness score 39 out of 100. Disease mechanisms

Topic: Disease mechanisms in lab and animal studies

The aim of this study was to investigate the effects of netrin-1 (NT-1) on amyloid-beta (Aβ)-induced impairments in learning-memory and synaptic plasticity. The NT-1 or its vehicle was administered four times into the Aβ+NT or Aβ+V groups, respectively. The Aβ+SNT group received a single dose of NT-1. The Aβ+HNT group received heat-inactivated NT-1. For the learning-memory and synaptic plasticity assessment, field potentials recording and behavioral experiment were used. Bilateral injection of Aβ1-42 inhibits induction of long-term potentiation (LTP) and decreased memory performance in all the behavioral tasks. However, only by repeated injection of NT-1, significant recovery of LTP and memory was seen. Although, the delivery of HFS to Aβ+NT group recovered EPSP slope of the maintenance phase when compared with Aβ+V, but it failed to recover the induction phase. It can be assumed that NT-1 may have regulatory effects on the synthesis of key proteins and/or structural changes that are responsible for LTP induction, since the protein synthesis and/or structural changes are required for the maintenance phase of LTP.

Key findings

However, only by repeated injection of NT-1, significant recovery of LTP and memory was seen.
Although, the delivery of HFS to Aβ+NT group recovered EPSP slope of the maintenance phase when compared with Aβ+V, but it failed to recover the induction phase.

Study details

Evidence strengthLow

How this study scored 39/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 22 of the 56 points we could judge it on, which is 39 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Brain research bulletin)
Journal's citation record	— / 4	No journal record from OpenAlex — left out of this score
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2017 — within 10 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	— / 7	No citation count (not found in OpenAlex) — left out of this score
Citations per year	— / 5	No citation count or no year — left out of this score
Impact for its field and year	— / 6	No field-weighted citation impact (OpenAlex has none yet) — left out of this score
Cited by studies here	— / 6	Not yet checked against this library's citation graph — left out of this score
Still being cited	— / 4	No yearly citation counts — left out of this score
Senior author's track record	— / 4	Senior author's record not available — left out of this score
Institution's track record	— / 3	No institution listed in OpenAlex — left out of this score
Multi-centre collaboration	— / 3	Institutions not listed — left out of this score
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 28389207)
Free to read	— / 2	Access not recorded — left out of this score
Points	22 / 56	Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 22 of the 56 points we could judge it on is 39 out of 100.
Total	39 / 100	—

What each of these 20 components measures, and what this score is not →

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Cite this study APA, Vancouver, BibTeX · download .bib or .ris

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APA 7th

Shabani, M., Haghani, M., Tazangi, P. E., Bayat, M., Moosavi, S. M. S., & Ranjbar, H. (2017). Netrin-1 improves the amyloid-β-mediated suppression of memory and synaptic plasticity. Brain research bulletin. https://doi.org/10.1016/j.brainresbull.2017.03.015

Vancouver

Shabani M, Haghani M, Tazangi PE, Bayat M, Moosavi SMS, Ranjbar H. Netrin-1 improves the amyloid-β-mediated suppression of memory and synaptic plasticity. Brain research bulletin. 2017. doi:10.1016/j.brainresbull.2017.03.015. PMID: 28389207.

BibTeX

@article{shabani2017-28389207,
  author  = {Shabani, Mohammad and Haghani, Masoud and Tazangi, Parisa Esmaeili and Bayat, Mahnaz and Moosavi, Seyed Mostafa Shid and Ranjbar, Hoda},
  title   = {{Netrin-1 improves the amyloid-β-mediated suppression of memory and synaptic plasticity}},
  journal = {Brain research bulletin},
  year    = {2017},
  doi     = {10.1016/j.brainresbull.2017.03.015},
  pmid    = {28389207},
  url     = {https://doi.org/10.1016/j.brainresbull.2017.03.015}
}

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