This page is alzhub.org's plain-English summary of a published study, not the paper itself. It is generated from the record we hold for this study, sourced and linked below — check the original for the full text and methods.

59/100

✓ Peer-reviewed alzhub usefulness score 59 out of 100. Long-term cohort studies

Topic: Amyloid, tau and blood-test diagnosis

Background The relative performance of semi-quantitative amyloid positron emission tomography (PET) and cerebrospinal fluid (CSF) markers in diagnosing Alzheimer's disease (AD) and predicting the cognitive evolution of patients with mild cognitive impairment (MCI) is still debated. Methods Subjects from the Alzheimer's Disease Neuroimaging Initiative 2 with complete baseline cognitive assessment (Mini Mental State Examination, Clinical Dementia Rating [CDR] and Alzheimer's Disease Assessment Scale-Cognitive Subscale [ADAS-cog] scores), CSF collection (amyloid-β 1-42 [Aβ], tau and phosphorylated tau) and 18 F-florbetapir scans were included in our cross-sectional cohort. Among these, patients with MCI or substantial memory complaints constituted our longitudinal cohort and were followed for 30 ± 16 months.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Ben Bouallègue, F., Mariano-Goulart, D., & Payoux, P. (2017). Comparison of CSF markers and semi-quantitative amyloid PET in Alzheimer's disease diagnosis and in cognitive impairment prognosis using the ADNI-2 database. Alzheimer's research & therapy. https://doi.org/10.1186/s13195-017-0260-z

Vancouver

Ben Bouallègue F, Mariano-Goulart D, Payoux P. Comparison of CSF markers and semi-quantitative amyloid PET in Alzheimer's disease diagnosis and in cognitive impairment prognosis using the ADNI-2 database. Alzheimer's research & therapy. 2017. doi:10.1186/s13195-017-0260-z. PMID: 28441967.

BibTeX

@article{benbouallegue2017-28441967,
  author  = {Ben Bouallègue, F. and Mariano-Goulart, D. and Payoux, P.},
  title   = {{Comparison of CSF markers and semi-quantitative amyloid PET in Alzheimer's disease diagnosis and in cognitive impairment prognosis using the ADNI-2 database}},
  journal = {Alzheimer's research \& therapy},
  year    = {2017},
  doi     = {10.1186/s13195-017-0260-z},
  pmid    = {28441967},
  url     = {https://doi.org/10.1186/s13195-017-0260-z}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.

Key findings

Methods Subjects from the Alzheimer's Disease Neuroimaging Initiative 2 with complete baseline cognitive assessment (Mini Mental State Examination, Clinical Dementia Rating [CDR] and Alzheimer's Disease Assessment Scale-Cognitive Subscale [ADAS-cog] scores), CSF collection (amyloid-β 1-42 [Aβ], tau and phosphorylated tau) and 18 F-florbetapir scans were included in our cross-sectional cohort.
Among these, patients with MCI or substantial memory complaints constituted our longitudinal cohort and were followed for 30 ± 16 months.
PET amyloid deposition was quantified using relative retention indices (standardised uptake value ratio [SUVr]) with respect to pontine, cerebellar and composite reference regions.
Diagnostic and prognostic performance based on PET and CSF was evaluated using ROC analysis, multivariate linear regression and survival analysis with the Cox proportional hazards model.

Why it matters

This study compared semi-quantitative amyloid PET and cerebrospinal fluid markers for diagnosing Alzheimer's disease and predicting cognitive decline in people with mild cognitive impairment or memory complaints. It is about diagnostic and prognostic testing, not treatment, cure, or prevention.

Study details

Study designcross-sectional
Participants677
Effect sizeAUC 0.88; AUC 0.83; AUC 0.86
Evidence strengthModerate

How this study scored 59/100

Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer's research & therapy)
Journal's citation record	1 / 4	Alzheimer s Research & Therapy: journal h-index 146 (OpenAlex, 2026-10-29)
Study design	4 / 12	A snapshot of people at one point in time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2017 — within 10 year(s) of the newest study here
Sample size	2 / 4	677 participants
Effect reported	3 / 3	Effect reported with a statistic (interval, p-value, ratio or similar)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	4 / 7	Cited 71 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	6.5 citations a year over 11 year(s) since 2017
Impact for its field and year	3 / 6	Cited 7.2× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 7 other studies in this library
Still being cited	2 / 4	Cited 16 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Pierre Payoux: h-index 46 (OpenAlex, whole career)
Institution's track record	2 / 3	Inserm: institution h-index 1,988 (OpenAlex)
Multi-centre collaboration	3 / 3	OpenAlex lists 10 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 28441967)
Free to read	2 / 2	Free to read
Total	59 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Studies this one cites

Referenced by this study and also in the alzhub library, so you can read them here. Showing 12 of 29.

Later studies that cite this one

7 studies in the alzhub library list this one in their references.

Related studies in Long-term cohort studies

Also tagged “cerebrospinal”

820 studies in the library carry the topic tag “cerebrospinal”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 820 tagged studies.

Studies sharing this one's topic tags

Similar studies

More on Long-term cohort studies

See all studies in Long-term cohort studies →