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TREM2-Ligand Interactions in Health and Disease
Kober DL, Brett TJ.. Journal of molecular biology, 2017-04-19
Topic: Brain proteins, microglia and lab models
The protein triggering receptor expressed on myeloid cells-2 (TREM2) is an immunomodulatory receptor with a central role in myeloid cell activation and survival. In recent years, the importance of TREM2 has been highlighted by the identification of coding variants that increase risk for Alzheimer's disease and other neurodegenerative diseases. Animal studies have further shown the importance of TREM2 in neurodegenerative and other inflammatory disease models including chronic obstructive pulmonary disease, multiple sclerosis, and stroke.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Kober, D. L., & Brett, T. J. (2017). TREM2-Ligand Interactions in Health and Disease. Journal of molecular biology. https://doi.org/10.1016/j.jmb.2017.04.004
Vancouver
Kober DL, Brett TJ. TREM2-Ligand Interactions in Health and Disease. Journal of molecular biology. 2017. doi:10.1016/j.jmb.2017.04.004. PMID: 28432014.
BibTeX
@article{kober2017-28432014,
author = {Kober, D. L. and Brett, T. J.},
title = {{TREM2-Ligand Interactions in Health and Disease}},
journal = {Journal of molecular biology},
year = {2017},
doi = {10.1016/j.jmb.2017.04.004},
pmid = {28432014},
url = {https://doi.org/10.1016/j.jmb.2017.04.004}
}
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Key findings
- In recent years, the importance of TREM2 has been highlighted by the identification of coding variants that increase risk for Alzheimer's disease and other neurodegenerative diseases.
- Animal studies have further shown the importance of TREM2 in neurodegenerative and other inflammatory disease models including chronic obstructive pulmonary disease, multiple sclerosis, and stroke.
- A mechanistic understanding of TREM2 function remains elusive, however, due in part to the absence of conclusive information regarding the identity of endogenous TREM2 ligands.
- While many TREM2 ligands have been proposed, their physiological role and mechanism of engagement remain to be determined.
Why it matters
This 2017 review starts from background it summarises: TREM2 coding variants "increase risk for Alzheimer's disease and other neurodegenerative diseases", and animal studies point to TREM2's importance in models including COPD, multiple sclerosis and stroke. Its focus is an open question: TREM2's mechanism "remains elusive", in part because the identity of its natural binding partners (ligands) is not conclusively known, and the many ligands proposed have a "physiological role and mechanism of engagement" that "remain to be determined". The record reports no new data and no named ligand, and it tests no treatment.
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Study details
- Evidence strengthLow
How this study scored 48/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of molecular biology) |
| Journal's citation record | 3 / 4 | Journal of Molecular Biology: journal h-index 484 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2017 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 284 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 25.8 citations a year over 11 year(s) since 2017 |
| Impact for its field and year | 3 / 6 | Cited 5.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 4 / 6 | Cited by 41 other studies in this library |
| Still being cited | 3 / 4 | Cited 116 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Tom J. Brett: h-index 30 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Washington University in St. Louis: institution h-index 1,962 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 28432014) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 48 / 100 | — |
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