Newest studies

Evaluation of optical coherence tomography angiographic findings in Alzheimer's type dementia

49/100 ✓ Peer-reviewed Cognitive tests and assessment The British journal of ophthalmology

Key finding: Our study included 26 patients in the patient group, and age-matched and sex-matched 26 subjects in the control group. +3 more findings

Full summary, score breakdown and related studies → Original source

Advances in arterial spin labelling MRI methods for measuring perfusion and collateral flow

44/100 ✓ Peer-reviewed Digital health tools Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Key finding: In this review article new developments and remaining issues will be discussed, especially focusing on quantification of ASL as well as on new technological developments of ASL for perfusion imaging and flow territory mapping. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

The landscape of genetic diseases in Saudi Arabia based on the first 1000 diagnostic panels and exomes

58/100 ✓ Peer-reviewed Disparities Human genetics

Key finding: If the novel candidate disease genes in this cohort are independently confirmed, the yield of WES will have increased to 83%, which suggests that most "negative" clinical exome tests are unsolved due to interpretation rather than technical limitations.

• Genetics
• Diagnosis

Full summary, score breakdown and related studies → Original source

Cognitive reserve is not associated with improved performance in all cognitive domains

39/100 ✓ Peer-reviewed Risk factors Applied neuropsychology. Adult

Key finding: Bootstrapped regression analyses revealed that cognitive reserve was associated with attention, executive functions, verbal and working memory, and orientation; and not significantly related to emotion perception, processing speed, or motor performance. +1 more finding

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Cerebral Blood Flow and Amyloid-β Interact to Affect Memory Performance in Cognitively Normal Older Adults

44/100 ✓ Peer-reviewed Long-term cohort studies Frontiers in aging neuroscience

Key finding: Less is known about how CBF and Aβ may interact to affect cognition in cognitively normal older adults. +3 more findings

• Early Stage

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A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease

61/100 ✓ Peer-reviewed TREM2 and immune genetics Cell

Key finding: Due to cellular heterogeneity, defining the roles of immune cell subsets in AD onset and progression has been challenging. +3 more findings

• Brain Biology

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Regulation of postsynaptic signaling in structural synaptic plasticity

39/100 ✓ Peer-reviewed Disease mechanisms Current opinion in neurobiology

Key finding: Morphological changes of dendritic spines are strongly associated with synaptic development and synaptic plasticity, which underlies learning and memory.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Building research in diet and cognition: The BRIDGE randomized controlled trial

78/100 ✓ Peer-reviewed Prevention trials Contemporary clinical trials

Key finding: Adherence to a Mediterranean Diet (MedDiet) is associated with reduced risk of cognitive impairment and dementia.

• Clinical Trials
• Lifestyle
• Risk Factors

Full summary, score breakdown and related studies → Original source

Physical Exercise with Music Reduces Gray and White Matter Loss in the Frontal Cortex of Elderly People: The Mihama-Kiho Scan Project

48/100 ✓ Peer-reviewed Prevention trials Frontiers in aging neuroscience

Key finding: However, the brain plasticity associated with these proposed benefits of combined therapy has not yet been investigated in elderly subjects. +4 more findings

• Lifestyle

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Enhanced classical complement pathway activation and altered phagocytosis signaling molecules in human epilepsy

44/100 ✓ Peer-reviewed TREM2 and immune genetics Experimental neurology

Key finding: Although microglial cells are professional phagocytes, less is known about the status of this phenotype in epilepsy. +3 more findings

• Brain Biology

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TREM2 protects against cerebral ischemia/reperfusion injury

46/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular brain

Key finding: Here, we found that the transcriptional and post-transcriptional levels of TREM2 were increased in cultured primary microglia after oxygen-glucose deprivation and reoxygenation and in the ischemic penumbra of the cerebral cortex after middle cerebral artery occlusion (MCAO) and reperfusion in mice. +3 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Functional network integrity presages cognitive decline in preclinical Alzheimer disease

66/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: In clinically normal older adults, lower functional connectivity predicted more rapid decline in PACC scores over time, particularly when coupled with increased Aβ burden. +1 more finding

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium

67/100 ✓ Peer-reviewed Getting a diagnosis Neurology

Key finding: Minor modifications to pathologic methods and criteria are recommended to take account of Alzheimer disease neuropathologic change, to add previously omitted Lewy-related pathology categories, and to include assessments for substantia nigra neuronal loss. +4 more findings

• Other Dementias
• Diagnosis

Full summary, score breakdown and related studies → Original source

CSF sAPPβ, YKL-40, and neurofilament light in frontotemporal lobar degeneration

61/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: The combination of sAPPβ with YKL-40 and with NfL in CSF could be useful to increase the certainty of the diagnosis of FTLD-related syndromes in clinical practice. +1 more finding

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Metformin - a Future Therapy for Neurodegenerative Diseases : Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla

41/100 ✓ Peer-reviewed Drug development Pharmaceutical research

Key finding: Esteemed published articles and epidemiological data exhibit an increased risk of developing Alzheimer's disease (AD) in diabetic pateints. +1 more finding

• Treatments
• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

Efficacy of the Ubiquitous Spaced Retrieval-based Memory Advancement and Rehabilitation Training (USMART) program among patients with mild cognitive impairment: a randomized controlled crossover trial

76/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's research & therapy

Key finding: The 4-week USMART modestly improved information retrieval in older people with MCI, and was well accepted with minimal technical support. +2 more findings

• Clinical Trials
• Early Stage

Full summary, score breakdown and related studies → Original source

Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity

45/100 ✓ Peer-reviewed Disease mechanisms Nature communications

Key finding: Although multiple CHCHD10 mutations are associated with the spectrum of familial and sporadic frontotemporal dementia-amyotrophic lateral sclerosis (FTD-ALS) diseases, neither the normal function of endogenous CHCHD10 nor its role in the pathological milieu (that is, TDP-43 pathology) of FTD/ALS have been investigated. +1 more finding

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Cerebral Perfusion and the Risk of Dementia: A Population-Based Study

67/100 ✓ Peer-reviewed Long-term cohort studies Circulation

Key finding: Cerebral hypoperfusion has previously been associated with mild cognitive impairment and dementia in various cross-sectional studies, but whether hypoperfusion precedes neurodegeneration is unknown. +3 more findings

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Cognitive Training and Noninvasive Brain Stimulation for Cognition in Parkinson's Disease: A Meta-analysis

66/100 ✓ Peer-reviewed Prevention trials Neurorehabilitation and neural repair

Key finding: The results suggest that standard and tailored cognitive training may improve executive function, attention/working memory, and memory in PD. +4 more findings

• Clinical Trials
• Other Dementias
• Lifestyle

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Astrocyte-derived lipocalin-2 mediates hippocampal damage and cognitive deficits in experimental models of vascular dementia

38/100 ✓ Peer-reviewed Inflammation and the immune system Glia

Key finding: Furthermore, Lcn2-deficient mice, compared with wild-type animals, showed significantly weaker CA1 neuronal loss, cognitive decline, white matter damage, blood-brain barrier permeability, glial activation, and proinflammatory cytokine production in the hippocampus after tBCCAo. +2 more findings

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Effects of metformin exposure on neurodegenerative diseases in elderly patients with type 2 diabetes mellitus

69/100 ✓ Peer-reviewed Costs and economics Progress in neuro-psychopharmacology & biological psychiatry

Key finding: Epidemiological evidence reveals that patients with type 2 diabetes mellitus (T2DM) have an increased risk of neurodegenerative diseases (NDs), including dementia and Parkinson's disease (PD). +2 more findings

• Risk Factors

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Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's disease

56/100 ✓ Peer-reviewed Getting a diagnosis NeuroImage

Key finding: While all tau measures were related to amyloid and global cognition, memory and hippocampal/entorhinal volume/thickness were associated with regional tracer retention in the medial temporal lobe. +1 more finding

• Brain Scans
• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats

38/100 ✓ Peer-reviewed Drug development Molecular neurobiology

Key finding: Chronic Ex-4 treatment attenuated peripheral features of T2D in GK rats, including hyperglycemia and insulin resistance. +4 more findings

• Treatments

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[Clocks, Behavior, and Cognition]

39/100 ✓ Peer-reviewed Risk factors Brain and nerve = Shinkei kenkyu no shinpo

Key finding: Factors that can contribute to this include reduced expression of the time gene associated with photo stimulation, a reduction in neurotransmitter levels, and reduced melatonin production. +2 more findings

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ApoE isoforms differentially regulates cleavage and secretion of BDNF

43/100 ✓ Peer-reviewed Genetics Molecular brain

Key finding: Here we report that in the hippocampal regions of AD patients both prepro-BDNF and pro-BDNF expression showed a 40 and 60% decrease respectively compared to that expression in the hippocampi of age-matched control patients. +4 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source