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Subjective Cognitive Decline in Preclinical Alzheimer's Disease
Rabin LA, Smart CM, Amariglio RE.. Annual review of clinical psychology, 2017-05-01
Topic: Amyloid, tau and blood-test diagnosis
Older adults with subjective cognitive decline (SCD) in the absence of objective neuropsychological dysfunction are increasingly viewed as at risk for non-normative cognitive decline and eventual progression to Alzheimer's disease (AD) dementia. The past decade has witnessed tremendous growth in research on SCD, which may reflect the recognition of SCD as the earliest symptomatic manifestation of AD. Yet methodological challenges associated with establishing common assessment and classification procedures hamper the construct. This article reviews essential features of SCD associated with preclinical AD and current measurement approaches, highlighting challenges in harmonizing study findings across settings. We consider the relation of SCD to important variables and outcomes (e.g., AD biomarkers, clinical progression). We also examine the role of self- and informant-reports in SCD and various psychological, medical, and demographic factors that influence the self-report of cognition. We conclude with a discussion of intervention strategies for SCD, ethical considerations, and future research priorities.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Rabin, L. A., Smart, C. M., & Amariglio, R. E. (2017). Subjective Cognitive Decline in Preclinical Alzheimer's Disease. Annual review of clinical psychology. https://doi.org/10.1146/annurev-clinpsy-032816-045136
Vancouver
Rabin LA, Smart CM, Amariglio RE. Subjective Cognitive Decline in Preclinical Alzheimer's Disease. Annual review of clinical psychology. 2017. doi:10.1146/annurev-clinpsy-032816-045136. PMID: 28482688.
BibTeX
@article{rabin2017-28482688,
author = {Rabin, L. A. and Smart, C. M. and Amariglio, R. E.},
title = {{Subjective Cognitive Decline in Preclinical Alzheimer's Disease}},
journal = {Annual review of clinical psychology},
year = {2017},
doi = {10.1146/annurev-clinpsy-032816-045136},
pmid = {28482688},
url = {https://doi.org/10.1146/annurev-clinpsy-032816-045136}
}
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Key findings
- Yet methodological challenges associated with establishing common assessment and classification procedures hamper the construct.
- This article reviews essential features of SCD associated with preclinical AD and current measurement approaches, highlighting challenges in harmonizing study findings across settings.
- We conclude with a discussion of intervention strategies for SCD, ethical considerations, and future research priorities.
Why it matters
This review discusses subjective cognitive decline as a possible earliest symptomatic manifestation of Alzheimer's disease and notes challenges in assessment and classification. It reports no treatment, cure or prevention.
Study details
- Evidence strengthLow
How this study scored 53/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Annual review of clinical psychology) |
| Journal's citation record | 2 / 4 | Annual Review of Clinical Psychology: journal h-index 186 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2017 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 590 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 53.6 citations a year over 11 year(s) since 2017 |
| Impact for its field and year | 3 / 6 | Cited 6.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 15 other studies in this library |
| Still being cited | 4 / 4 | Cited 221 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Rebecca England Amariglio: h-index 57 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 7 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 28482688) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 53 / 100 | — |
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