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High-Level Alzheimer Disease Neuropathological Change Following Iatrogenic Exposure
Gargi Banerjee, Tze How Mok, Harpreet Hyare, Oliver Cousins, Zane Jaunmuktane, Simon Mead, John Collinge. JAMA Neurology, 2026-03-30
Topic: Amyloid, tau and blood-test diagnosis
The study describes 4 males who developed dementia following confirmed or suspected c-hGH treatment in childhood (age at symptom onset between 47 and 60 years) with cognitive syndromes characterized by prominent language involvement. Results include clinical and postmortem findings for 1 patient (onset at age 47 years) in whom postmortem examination (at age 57 years) showed unequivocal neuropathological features of AD, including severe tauopathy. Brief descriptions of 3 additional patients with prominent language involvement are also provided. Conclusions and Relevance: These results demonstrate that patients with iAD can have histopathological findings classically found in sporadic AD and that prominent language involvement might be an important phenotypic feature in this AD subtype.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Banerjee, G., Mok, T. H., Hyare, H., Cousins, O., Jaunmuktane, Z., Mead, S., et al. (2026). High-Level Alzheimer Disease Neuropathological Change Following Iatrogenic Exposure. JAMA Neurology. https://doi.org/10.1001/jamaneurol.2026.0437
Vancouver
Banerjee G, Mok TH, Hyare H, Cousins O, Jaunmuktane Z, Mead S, et al. High-Level Alzheimer Disease Neuropathological Change Following Iatrogenic Exposure. JAMA Neurology. 2026. doi:10.1001/jamaneurol.2026.0437. PMID: 41910964.
BibTeX
@article{banerjee2026-41910964,
author = {Banerjee, Gargi and Mok, Tze How and Hyare, Harpreet and Cousins, Oliver and Jaunmuktane, Zane and Mead, Simon and Collinge, John},
title = {{High-Level Alzheimer Disease Neuropathological Change Following Iatrogenic Exposure}},
journal = {JAMA Neurology},
year = {2026},
doi = {10.1001/jamaneurol.2026.0437},
pmid = {41910964},
url = {https://doi.org/10.1001/jamaneurol.2026.0437}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- The study describes 4 males who developed dementia following confirmed or suspected c-hGH treatment in childhood (age at symptom onset between 47 and 60 years) with cognitive syndromes characterized by prominent language involvement.
- Results include clinical and postmortem findings for 1 patient (onset at age 47 years) in whom postmortem examination (at age 57 years) showed unequivocal neuropathological features of AD, including severe tauopathy.
- Brief descriptions of 3 additional patients with prominent language involvement are also provided.
- Conclusions and Relevance: These results demonstrate that patients with iAD can have histopathological findings classically found in sporadic AD and that prominent language involvement might be an important phenotypic feature in this AD subtype.
Why it matters
This describes four men who developed dementia after receiving c-hGH treatment in childhood, with one showing clear Alzheimer's-type brain changes at autopsy. It suggests that in rare cases Alzheimer's disease can be acquired through medical treatment, but this is a small case series and does not apply to most people with Alzheimer's.
Study details
- Participants14
- Evidence strengthLow
How this study scored 51/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (JAMA Neurology) |
| Journal's citation record | 2 / 4 | JAMA Neurology: journal h-index 235 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 1 / 4 | 14 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 5 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.5 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | 5 / 6 | Cited 20.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 5 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author John Collinge: h-index 53 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University College London: institution h-index 2,029 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41910964) |
| Free to read | 2 / 2 | Free to read |
| Total | 51 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1001/jamaneurol.2026.0437
- PubMed: 41910964
- Original source →
- Free full text: JAMA Neurology →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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