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48/100

✓ Peer-reviewed alzhub usefulness score 48 out of 100. Brain scans and imaging

Topic: Brain proteins, microglia and lab models

Plain-language summary

There was an age-related increase in both 18 F-AV-1451 binding in the basal ganglia and R 2 * values in the putamen in both the controls and the Alzheimer disease/mild cognitive impairment patients. 18 F-AV-1451 binding in the basal ganglia increased with R 2 * values. Off-target 18 F-AV-1451 binding in the basal ganglia is associated with the age-related increases in iron accumulation. Postmortem studies are required to further investigate the nature of this association.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Choi, J. Y., Cho, H., Ahn, S. J., Lee, J. H., Ryu, Y. H., Lee, M. S., et al. (2018). Off-Target 18F-AV-1451 Binding in the Basal Ganglia Correlates with Age-Related Iron Accumulation. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. https://doi.org/10.2967/jnumed.117.195248

Vancouver

Choi JY, Cho H, Ahn SJ, Lee JH, Ryu YH, Lee MS, et al. Off-Target 18F-AV-1451 Binding in the Basal Ganglia Correlates with Age-Related Iron Accumulation. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2018. doi:10.2967/jnumed.117.195248. PMID: 28775201.

BibTeX

@article{choi2018-28775201,
  author  = {Choi, J. Y. and Cho, H. and Ahn, S. J. and Lee, J. H. and Ryu, Y. H. and Lee, M. S. and Lyoo, C. H.},
  title   = {{Off-Target 18F-AV-1451 Binding in the Basal Ganglia Correlates with Age-Related Iron Accumulation}},
  journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year    = {2018},
  doi     = {10.2967/jnumed.117.195248},
  pmid    = {28775201},
  url     = {https://doi.org/10.2967/jnumed.117.195248}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

How to read this study

Design: our record does not state a study design, so check the methods section of the original before weighing the result.
Size: the record lists 61 participants. Ask whether that is enough for the question, and who they were.
Effect: the record gives no effect size, so the summary above cannot say how large any difference was.

What the evidence grade means here

This page is graded low. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. Low means the abstract matched neither pattern. It is the default label, and it does not mean the work is poor; many sound lab and imaging papers land here. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

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Key findings

There was an age-related increase in both 18 F-AV-1451 binding in the basal ganglia and R 2 * values in the putamen in both the controls and the Alzheimer disease/mild cognitive impairment patients. 18 F-AV-1451 binding in the basal ganglia increased with R 2 * values.
Off-target 18 F-AV-1451 binding in the basal ganglia is associated with the age-related increases in iron accumulation.
Postmortem studies are required to further investigate the nature of this association.

Why it matters

This study shows that a commonly used tau PET tracer binds to iron in the basal ganglia as people age, which is not related to Alzheimer's disease itself. This means some tracer signal in that brain region may not reflect Alzheimer's pathology, and more autopsy work is needed to understand this.

New to this subject? Start with our plain-English guide: Brain scans & tests →

Study details

Participants61
Evidence strengthLow

How this study scored 48/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of nuclear medicine : official publication, Society of Nuclear Medicine)
Journal's citation record	2 / 4	Journal of Nuclear Medicine: journal h-index 230 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2018 — within 10 year(s) of the newest study here
Sample size	1 / 4	61 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	4 / 7	Cited 92 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	9.2 citations a year over 10 year(s) since 2018
Impact for its field and year	4 / 6	Cited 9.2× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 4 other studies in this library
Still being cited	2 / 4	Cited 24 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Chul Hyoung Lyoo: h-index 44 (OpenAlex, whole career)
Institution's track record	1 / 3	Yonsei University: institution h-index 777 (OpenAlex)
Multicenter collaboration	2 / 3	OpenAlex lists 4 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 28775201)
Free to read	0 / 2	Behind a paywall — scores zero
Total	48 / 100	—

What each of these 20 components measures, and what this score is not →

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