Newest studies

Development and validation of a geriatric depression screening scale: A preliminary report

54/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Psychiatric Research

Key finding: The GDS, HRS-D and SDS were all found to be internally consistent measures, and each of the scales was correlated with the subject's number of RDC symptoms. +2 more findings

• Diagnosis

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Sleep, EEG and mental function changes in senile dementia of the Alzheimer's type

47/100 ✓ Peer-reviewed Risk factors Neurobiology of aging

Key finding: Sleep, EEG and mental function variables were studied in 44 subjects diagnosed as having probable senile dementia of the Alzheimer's type (SDAT) and 22 controls matched for age and minimal depression. +2 more findings

• Lifestyle

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Regional cerebral oxygen supply and utilization in dementia. A clinical and physiological study with oxygen-15 and positron tomography

40/100 ✓ Peer-reviewed Risk factors Brain : a journal of neurology

Key finding: The limitations of measurements are reviewed in the light of the present results and the current state of technological development in positron emission tomography is discussed.

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Some morphometric aspects of the brain in senile dementia of the Alzheimer type

47/100 ✓ Peer-reviewed Brain scans and imaging Annals of neurology

Key finding: The concentration of neuritic plaques did not correlate significantly with brain weight, cortical thickness, or cell counts.

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Depression, intellectual impairment, and Parkinson disease

48/100 ✓ Peer-reviewed How common it is Neurology

Key finding: Using the Beck criteria, 47% of the patients and 12% of the spouses rated themselves as significantly depressed. +3 more findings

• Other Dementias

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Senile dementia: combined pharmacologic and psychologic treatment

43/100 ✓ Peer-reviewed Prevention trials Journal of the American Geriatrics Society

Key finding: DEM was administered orally to 21 moderately demented subjects, in a dosage of 1 mg three times daily; and SC or CT was conducted for one hour every two weeks for a total of 12 weeks. +4 more findings

• Treatments

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Physostigmine and Arecoline: Effects of Intravenous Infusions in Alzheimer Presenile Dementia

43/100 ✓ Peer-reviewed Clinical trials The British Journal of Psychiatry

Key finding: Significant improvement was seen on a picture recognition test with physostigmine 0.375 mg and arecholine 4 mg.

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Relatives of the Impaired Elderly: Correlates of Feelings of Burden

54/100 ✓ Peer-reviewed Caregiving The Gerontologist

Key finding: Severity of behavioral problems was not associated with higher levels of burden. +1 more finding

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Reduced amounts of immunoreactive somatostatin in the temporal cortex in senile dementia of Alzheimer type

47/100 ✓ Peer-reviewed Getting a diagnosis Neuroscience letters

Key finding: Post-mortem brain tissue from 15 patients dying with a diagnosis of senile dementia of Alzheimer type (SDAT) was compared with tissue obtained from 16 control patients at routine post-mortem. +2 more findings

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Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer disease and Alzheimer senile dementa

41/100 ✓ Peer-reviewed Brain tissue and pathology Nature

Key finding: We report here results obtained with a RIA for somatostatin, showing that somatostatin-like immunoreactivity in the cerebral cortex is reduced in tissue from AD/SDAT patients.

• Brain Biology

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Hearing impairment and mental state in the elderly living at home

48/100 ✓ Peer-reviewed Risk factors British medical journal

Key finding: A significant relation between deafness and depression was independent of age and socioeconomic state.

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Glial fibrillary acidic protein and Alzheimer-type senile dementia

43/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: Glial fibrillary acidic protein (GFAP), a protein that is associated with 9-nm filaments of astrocytes, was observed to be increased in the astrocytes surrounding senile plaques in patients with Alzheimer dementia and in aged subjects without dementia. +1 more finding

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Relationship between plaques, tangles, and dementia in Down syndrome

51/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neurology

Key finding: We studied 20 Down syndrome patients dying after age 30 (average age, 49); all had neocortical plaques and tangles, but only 3 of 20 had been demented. +4 more findings

• Brain Biology
• Down Syndrome

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Neurofibrillary tangles, granulovacuolar degeneration, and neuron loss in Down Syndrome: quantitative comparison with Alzheimer dementia

43/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Annals of neurology

Key finding: These morphometric results were compared with values obtained from a series of mentally normal elderly patients reported previously.

• Brain Biology
• Down Syndrome

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Pathological verification of ischemic score in differentiation of dementias

49/100 ✓ Peer-reviewed Getting a diagnosis Annals of neurology

Key finding: Fourteen case histories of persons who had a histological diagnosis of either senile dementia of the Alzheimer type, multiinfarct dementia, or a mixed dementia composed of these two types and who showed evidence of a moderate to severe dementia on psychological testing were rated for the presence of thirteen clinical features comprising Hachinski's Ischemic Score. +4 more findings

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The Galveston Orientation and Amnesia Test. A practical scale to assess cognition after head injury

43/100 ✓ Peer-reviewed Brain scans and imaging The Journal of nervous and mental disease

Key finding: Duration of post-traumatic amnesia, as defined by the persistence of defective GOAT scores, was longer in patients with computed tomographic evidence of diffuse or bilateral brain injury as compared to cases with focal unilateral lesions.

• Risk Factors

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Studies in aging of the brain: IV. Familial Alzheimer disease: Relation to transmissible dementia, aneuploidy, and microtubular defects

43/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neurology

Key finding: Alzheimer disease is associated with abnormal neurofibrillary structures, Down syndrome, and abnormal numbers of chromosomes in lymphocytes (aneuploidy).

• Genetics

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Neurotransmitter-related enzymes in senile dementia of the Alzheimer type

36/100 ✓ Peer-reviewed Tau biomarkers Brain research

Key finding: Choline acetyltransferase (ChAT), acetylcholinesterase (AChE) and glutamic acid decarboxylase (GAD) activities were measured in 20 brain regions from autopsied control and senile dementia of the Alzheimer type (SDAT) cases. +2 more findings

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Alzheimer neurofibrillary tangles in diseases other than senile and presenile dementia

42/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Annals of neurology

Key finding: A brief description is given of neurofibrillary changes of the paired helical filament type in a variety of chronic neurological diseases. +3 more findings

• Brain Biology

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Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia

40/100 ✓ Peer-reviewed Risk factors British medical journal

Key finding: Choline acetyltransferase and acetylcholinesterase activities decreased significantly as the mean plaque count rose, and in depressed and demented subjects the reduction in choline acetyltransferase activity correlated with the extent of intellectual impairment as measured by a memory information test; muscarinic cholinergic receptor binding activity remained unchanged with increasing senile plaque formation but butyrylcholinesterase activity increased. +1 more finding

• Brain Biology

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CHANGES IN BRAIN CHOLINESTERASES IN SENILE DEMENTIA OF ALZHEIMER TYPE

40/100 ✓ Peer-reviewed Risk factors Neuropathology and Applied Neurobiology

Key finding: Acetylcholinesterase was significantly reduced and butyrylcholinesterase significantly increased, compared with the normal, in the hippocampus and temporal cortex of the Alzheimer cases. +2 more findings

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The dementia of dementia praecox

36/100 ✓ Peer-reviewed Digital health tools Acta Psychiatrica Scandinavica

Key finding: A group of 18 long‐stay patients with a diagnosis of schizophrenia were compared with a group of 10 age‐matched subjects who had been institutionalized by reason of physical disease, on performance on tests of intellectual function; and with a group of agematched healthy subjects, both on tests of intellectual function, and radiographically, using the technique of computerized axial tomography (EMI scan) of the brain. +4 more findings

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Role of aluminum in dialysis dementia

47/100 ✓ Peer-reviewed Digital health tools Annals of internal medicine

Key finding: Between September 1972 and January 1976 an outbreak of dialysis dementia affected 20 patients maintained by long-term hemodialysis. +4 more findings

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Unsuspected Emotional and Cognitive Disturbance in Medical Patients

48/100 ✓ Peer-reviewed End-of-life care Annals of Internal Medicine

Why assessment is of practical consequence to anaesthetistsGeneral Health Questionnaire (GHQ) in general hospitals: selecting a set of items using a stepwise hierarchical procedurePain assessment in cognitively impaired and unimpaired older adults: a comparison of four scalesMental disorders among internal medical inpatientsSuicide in Later Life: A Review and Recommendations for PreventionDELIRIUM IN THE TERMINALLY ILLRecognition of psychiatric disorders in nonpsychiatric hospital wardsNursing documentation versus standardized assessment of cognitive status in hospitalized medical patientsCompleted Suicide Among Older Patients in Primary Care Practices: A Controlled StudyDoes myasthenia gravis affect the brain?SUICIDAL PATIENTS IN THE ED: ETHICAL ISSUESMethodological issues of an epidemiological study: From the results of a study on psychological problems seen in outpatients visiting the internal medicine departments of general hospitalsPsychiatric disorders and vertigoTotal Quality Management and Geriatric CareAssessment and treatment of depression in the cancer patientUse of hospital services by AIDS patients with psychiatric illnessNeuropsychological and Pharmacokinetic Assessment of Hospice Inpatients Receiving MorphineMANAGEMENT OF SUICIDAL BEHAVIOR IN THE ELDERLYLiteraturverzeichnisSuicide in later lifeMajor depression in the primary care settingMaking the diagnosis of depression in the primary care settingThe Mini-Mental State Examination in General Medical Practice: Clinical Utility and AcceptancePsychological Morbidity in Obstetric-Gynaecology Patients: Testing the Need for Expanded Psychiatry Services in Obstetric-Gynaecology FacilitiesPrevalence of Psychiatric Disorders in Medical InpatientsTranstornos do humor em enfermaria de clínica médica e validação de escala de medida (HAD) de ansiedade e depressãoDelirium in Elderly Patients: Evaluation and ManagementDelirium Presenting With Symptoms of DepressionAnalysis of the terms used by general practitioners to characterize patients considered by them as depressed.

• Diagnosis
• Care Services

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Neurotransmitter enzyme abnormalities in senile dementia. Choline acetyltransferase and glutamic acid decarboxylase activities in necropsy brain tissue

36/100 ✓ Peer-reviewed Risk factors Journal of the neurological sciences

Key finding: Significant reductions in cerebral GAD have also been found in depression (unipolar). +2 more findings

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