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Incremental value of biomarker combinations to predict progression of mild cognitive impairment to Alzheimer's dementia
Frölich L, Peters O, Lewczuk P, Gruber O, Teipel SJ, Gertz HJ, Jahn H, Jessen F et al.. Alzheimer's research & therapy, 2017-10-10
Topic: Plasma and spinal-fluid biomarkers
ROC curves of the five best two-, three-, and four-parameter combinations were analyzed for significant superiority by a bootstrapping wrapper around a support vector machine with linear kernel. Results Out of 115 subjects, 28 (24.3%) with MCI progressed to AD dementia within a mean follow-up period of 25.5 months. All single biomarkers were significantly different between the two groups at baseline. None of the predictor combinations was significantly superior to the two best single predictors (HCV and t-Tau).
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APA 7th
Frölich, L., Peters, O., Lewczuk, P., Gruber, O., Teipel, S. J., Gertz, H. J., et al. (2017). Incremental value of biomarker combinations to predict progression of mild cognitive impairment to Alzheimer's dementia. Alzheimer's research & therapy. https://doi.org/10.1186/s13195-017-0301-7
Vancouver
Frölich L, Peters O, Lewczuk P, Gruber O, Teipel SJ, Gertz HJ, et al. Incremental value of biomarker combinations to predict progression of mild cognitive impairment to Alzheimer's dementia. Alzheimer's research & therapy. 2017. doi:10.1186/s13195-017-0301-7. PMID: 29017593.
BibTeX
@article{frolich2017-29017593,
author = {Frölich, L. and Peters, O. and Lewczuk, P. and Gruber, O. and Teipel, S. J. and Gertz, H. J. and Jahn, H. and Jessen, F. and others},
title = {{Incremental value of biomarker combinations to predict progression of mild cognitive impairment to Alzheimer's dementia}},
journal = {Alzheimer's research \& therapy},
year = {2017},
doi = {10.1186/s13195-017-0301-7},
pmid = {29017593},
url = {https://doi.org/10.1186/s13195-017-0301-7}
}
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Key findings
- ROC curves of the five best two-, three-, and four-parameter combinations were analyzed for significant superiority by a bootstrapping wrapper around a support vector machine with linear kernel.
- Results Out of 115 subjects, 28 (24.3%) with MCI progressed to AD dementia within a mean follow-up period of 25.5 months.
- All single biomarkers were significantly different between the two groups at baseline.
- None of the predictor combinations was significantly superior to the two best single predictors (HCV and t-Tau).
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Study details
- Study designcohort study
- Participants115
- Effect size24.3%; AUC 0.80-0.83; AUC 0.81-0.82
- Evidence strengthModerate
How this study scored 70/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record and institution's track record, so those were left out: it earned 43 of the 61 points we could judge it on, which is 70 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer's research & therapy) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2017 — within 10 year(s) of the newest study here |
| Sample size | 2 / 4 | 115 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | 2 / 3 | PubMed indexes it as a multicentre study |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 29017593) |
| Free to read | 2 / 2 | Free to read |
| Points | 43 / 61 | Scored on 12 of 20 parts. We have no data for the rest, so they are left out: 43 of the 61 points we could judge it on is 70 out of 100. |
| Total | 70 / 100 | — |
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