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High TREM2 expression correlates with poor prognosis in gastric cancer
Zhang X, Wang W, Li P, Wang X, Ni K.. Human pathology, 2017-11-02
Topic: Brain proteins, microglia and lab models
Triggering receptor expressed on myeloid cells 2 (TREM2) is a member of the immunoglobulin superfamily and associates with TYRO protein tyrosine kinase-binding protein at the cell membrane to form a receptor signaling complex. Gastric cancer (GC) is one of the most common human cancers in the world. We found that TREM2 expressions in GC and adjacent tissues were significantly different.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Zhang, X., Wang, W., Li, P., Wang, X., & Ni, K. (2018). High TREM2 expression correlates with poor prognosis in gastric cancer. Human pathology. https://doi.org/10.1016/j.humpath.2017.10.026
Vancouver
Zhang X, Wang W, Li P, Wang X, Ni K. High TREM2 expression correlates with poor prognosis in gastric cancer. Human pathology. 2018. doi:10.1016/j.humpath.2017.10.026. PMID: 29104108.
BibTeX
@article{zhang2018-29104108,
author = {Zhang, X. and Wang, W. and Li, P. and Wang, X. and Ni, K.},
title = {{High TREM2 expression correlates with poor prognosis in gastric cancer}},
journal = {Human pathology},
year = {2018},
doi = {10.1016/j.humpath.2017.10.026},
pmid = {29104108},
url = {https://doi.org/10.1016/j.humpath.2017.10.026}
}
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Key findings
- Gastric cancer (GC) is one of the most common human cancers in the world.
- We found that TREM2 expressions in GC and adjacent tissues were significantly different.
- The goal of this study was to measure TREM2 protein and mRNA expression levels in GC tissues and evaluate their value as potential prognostic markers.
- We analyzed TREM2 mRNA and protein expression by quantitative real-time polymerase chain reaction and immunohistochemistry, respectively, in 317 samples of GC tissue, matched normal tissue, or benign gastric lesions.
Why it matters
This study is about gastric cancer, not Alzheimer's disease. It found high TREM2 expression correlated with poor prognosis in gastric cancer, which does not inform Alzheimer's treatment.
New to this subject? Start with our plain-English guide: Genetics →
Study details
- Evidence strengthLow
How this study scored 39/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Human pathology) |
| Journal's citation record | 2 / 4 | Human Pathology: journal h-index 230 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 61 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 6.1 citations a year over 10 year(s) since 2018 |
| Impact for its field and year | 3 / 6 | Cited 4.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 8 other studies in this library |
| Still being cited | 2 / 4 | Cited 16 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Kan Ni: h-index 7 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Nantong University: institution h-index 261 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 29104108) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 39 / 100 | — |
What each of these 20 components measures, and what this score is not →
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