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Centiloid method evaluation for amyloid PET of subcortical vascular dementia
Hyuk Jin Yun, Seung Hwan Moon, Hee Jin Kim, Samuel N Lockhart, Yearn Seong Choe, Kyung Han Lee, Duk L Na, Jong-Min Lee et al.. Scientific reports, 2017-11-24
Topic: Plasma and spinal-fluid biomarkers
Reference region selection is important for proper amyloid PET analysis, especially in subcortical vascular dementia (SVaD) patients. We investigated reference region differences between SVaD and Alzheimer's disease (AD) using Centiloid scores. In 57 [C-11] Pittsburgh compound B (PiB) positive (+) AD and 23 PiB (+) SVaD patients, we assessed standardized PiB uptake and Centiloid scores in disease-specific cortical regions, with several reference regions: cerebellar gray (CG), whole cerebellum (WC), WC with brainstem (WC + B), pons, and white matter (WM). We calculated disease group differences from young controls (YC) and YC variance according to reference region. SVaD patients showed large effect sizes (Cohen's d > 0.8) using all reference regions. WM and pons showed larger YC variances than other regions. Findings were similar for AD patients. CG, WC, and WC + B, but not WM or pons, are reliable reference regions for amyloid imaging analysis in SVaD.
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APA 7th
Yun, H. J., Moon, S. H., Kim, H. J., Lockhart, S. N., Choe, Y. S., Lee, K. H., et al. (2017). Centiloid method evaluation for amyloid PET of subcortical vascular dementia. Scientific reports. https://doi.org/10.1038/s41598-017-16236-1
Vancouver
Yun HJ, Moon SH, Kim HJ, Lockhart SN, Choe YS, Lee KH, et al. Centiloid method evaluation for amyloid PET of subcortical vascular dementia. Scientific reports. 2017. doi:10.1038/s41598-017-16236-1. PMID: 29176753.
BibTeX
@article{yun2017-29176753,
author = {Yun, Hyuk Jin and Moon, Seung Hwan and Kim, Hee Jin and Lockhart, Samuel N and Choe, Yearn Seong and Lee, Kyung Han and Na, Duk L and Lee, Jong-Min and others},
title = {{Centiloid method evaluation for amyloid PET of subcortical vascular dementia}},
journal = {Scientific reports},
year = {2017},
doi = {10.1038/s41598-017-16236-1},
pmid = {29176753},
url = {https://doi.org/10.1038/s41598-017-16236-1}
}
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Key findings
- In 57 [C-11] Pittsburgh compound B (PiB) positive (+) AD and 23 PiB (+) SVaD patients, we assessed standardized PiB uptake and Centiloid scores in disease-specific cortical regions, with several reference regions: cerebellar gray (CG), whole cerebellum (WC), WC with brainstem (WC + B), pons, and white matter (WM).
- We calculated disease group differences from young controls (YC) and YC variance according to reference region.
- SVaD patients showed large effect sizes (Cohen's d > 0.8) using all reference regions.
- WM and pons showed larger YC variances than other regions.
- CG, WC, and WC + B, but not WM or pons, are reliable reference regions for amyloid imaging analysis in SVaD.
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Study details
- Evidence strengthLow
How this study scored 39/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 22 of the 56 points we could judge it on, which is 39 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Scientific reports) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2017 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 29176753) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 22 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 22 of the 56 points we could judge it on is 39 out of 100. |
| Total | 39 / 100 | — |
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