Newest studies

Detection and Classification of Alzheimer’s Disease Using Deep and Machine Learning

36/100 ✓ Peer-reviewed Digital health tools Tomography

Key finding: Random Forest achieves the highest accuracy of 97% on clinical data, while CNN achieves the best overall performance of 94% in MRI-based staging. +3 more findings

• Digital Tools
• Brain Scans

Full summary, score breakdown and related studies → Original source

Plasma p-tau212 identifies cognitively unimpaired individuals with emerging amyloid-β pathology

52/100 ✓ Peer-reviewed Biomarkers Journal of neurology

Key finding: Our results showed that all the plasma p-tau biomarkers are increased in the CU CSF Aβ + participants, with the highest median fold change observed for plasma p-tau212. +1 more finding

• Biomarkers
• Early Stage
• Treatments

Full summary, score breakdown and related studies → Original source

Advancing Early Detection of Alzheimer Disease in the Primary Care Setting in the United States

51/100 ✓ Peer-reviewed Health systems and care delivery Neurology. Clinical practice

Key finding: An advisory board was convened before and after the survey to advise on the survey design and discuss survey results.

• Care Services
• Diagnosis

Full summary, score breakdown and related studies → Original source

Differential Associations of Lipid Profiles with Dementia and Cardiovascular Disease: Findings from the UK Biobank Cohort

48/100 ✓ Peer-reviewed Long-term cohort studies Yonsei Medical Journal

Key finding: High LDL-C (≥160 mg/dL) increased AD risk across all groups {hazard ratio (HR): 1.23 [95% confidence interval (CI): 1.10-1.38],p<0.001;HR: 1.45 (95% CI: 1.08-1.93),p=0.013;HR: 1.25 (95% CI: 1.10-1.42),p<0.001, respectively}, whereas low LDL-C (<70 mg/dL) showed higher VD risk in those not taking cholesterol-lowering medication [HR: 3.02 (95% CI: 1.73-5.27),p<0.001].Low HDL-C (≤40 mg/dL) was associated with increased AD and VD risk in non-users. +1 more finding

• Risk Factors

Full summary, score breakdown and related studies → Original source

Cutaneous Phosphorylated Alpha‐Synuclein in Lewy Body Dementia

52/100 ✓ Peer-reviewed Getting a diagnosis Annals of Clinical and Translational Neurology

Key finding: After expert panel review, only 50/67 patients met consensus criteria for DLB, 26/151 controls had a reduced MoCA, and 120/151 controls had a normal MoCA. +4 more findings

Full summary, score breakdown and related studies → Original source

REDEFINING ALZHEIMER’S DISEASE THROUGH MODERN BIOTECHNOLOGY; FROM MOLECULAR PATHOGENESIS TO INNOVATIVE THERAPEUTICS AND DIAGNOSTIC FRONTIERS

27/100 ✓ Peer-reviewed Treatments Journal of medical & health sciences review.

Key finding: Biomarkers have played a crucial role in the pre determination of Alzheimer's disease and have used to make precautionary measures. +4 more findings

• Treatments
• Diagnosis
• Genetics

Full summary, score breakdown and related studies → Original source

Electronic Health Records to Test Multimorbidity Influences to Plasma Biomarker Interpretation for Alzheimer's Disease

53/100 ✓ Peer-reviewed Biomarkers Annals of neurology

Key finding: In this real-world dataset, we identified effects of multimorbidities on plasma biomarkers, especially kidney function. +1 more finding

• Biomarkers

Full summary, score breakdown and related studies → Original source

CSF biomarkers of neuroinflammation are associated with regional atrophy

59/100 ✓ Peer-reviewed Inflammation and the immune system Journal of neurology

Key finding: Higher synaptic latent factor (β = - 0.019, pFDR = 0.021) and YKL-40 (β = - 0.020, pFDR = 0.025) significantly predicted hippocampal atrophy. +4 more findings

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

The evolving landscape of Alzheimer's disease therapy: From Aβ to tau

43/100 ✓ Peer-reviewed Drug development Cell

Key finding: In this perspective, we highlight emerging outcomes of tau-targeting approaches with disease-modifying potential evidenced by PET-based slowing of tau accumulation and early signs of cognitive benefit. +4 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Virtual, Nurse-Led Early Primary Palliative Care Intervention (ELICIT) for Community-Dwelling Older Adults With Cognitive Impairment: Protocol for a Randomized Controlled Trial

45/100 ✓ Peer-reviewed End-of-life care JMIR Research Protocols

Key finding: As of October 2025, we have recruited 200 participants. +3 more findings

• End-of-Life Care
• Clinical Trials

Full summary, score breakdown and related studies → Original source

First-in-class SAM-competitive G9a inhibitor FLAV-27 as a disease-modifying therapy for Alzheimer disease

40/100 ✓ Peer-reviewed Tau biomarkers Molecular therapy : the journal of the American Society of Gene Therapy

Key finding: Here, we report the discovery and preclinical validation of FLAV-27, a first-in-class, S-adenosyl-l-methionine (SAM)-competitive, brain-penetrant, and selective inhibitor of the histone methyltransferase G9a. +3 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Mortality in long-term care residents: retrospective national cohort study

71/100 ✓ Peer-reviewed Health systems and care delivery BMJ supportive & palliative care

Key finding: Of 23 892 individuals moving-in to care homes, 20 250 (84.8%) died by 31 May 2020. +4 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

Glymphatic transport and ocular diseases

45/100 ✓ Peer-reviewed Brain scans and imaging Progress in retinal and eye research

Key finding: These include impaired laminar barrier integrity, pathological perivascular space expansion, aquaporin-4 abnormalities, immature vasculature, and pathological immune activation. +4 more findings

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APOE Lipoprotein Particles: Pathophysiology, Therapy, and the Crosstalk in Alzheimer's Disease and Cardiovascular Disease

46/100 ✓ Peer-reviewed Genetics Molecular neurobiology

Key finding: Individuals with APOE4 have an increased risk of developing the disease at an early age of onset. +1 more finding

• Genetics
• Risk Factors
• Treatments

Full summary, score breakdown and related studies → Original source

Delirium superimposed on dementia: clinical implications, challenges, and management strategies

28/100 ✓ Peer-reviewed Clinical safety Asian Journal of Gerontology and Geriatrics

Key finding: Delirium superimposed on dementia (DSD) is a frequent but underrecognised condition that complicates care in older adults.

Full summary, score breakdown and related studies → Original source

Shared Neuroinflammatory Mechanisms Across Dementia Types: An Integrative Review

36/100 ✓ Peer-reviewed Inflammation and the immune system International Journal of Molecular Sciences

Key finding: Recent advancements in neuroimaging techniques and biomarker discovery revealed potential therapeutic targets that may mitigate neuroinflammation. +1 more finding

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Association Between Gas‐Free Cerebrovascular Reactivity ( CVR ) and Cognitive Function in Older Adults With a High Risk for Vascular Dementia

48/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Magnetic Resonance Imaging

Key finding: Whole-brain bm-CVR values were significantly associated with the diagnosis group of normal, MCI, and early dementia (β = -3.00%/mm Hg, 95% confidence interval (CI) [-5.42, -0.58]), and were lower in the impaired participants relative to participants with normal cognition (β = -2.18, CI [-3.91, -0.45]). +4 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

CRISPR–Cas9–Mediated Genetic Correction for Alzheimer's Disease A Hypothetical Therapeutic Framework

39/100 ✓ Peer-reviewed Risk genes beyond APOE Zenodo (CERN European Organization for Nuclear Research)

Key finding: The repeated inability of Aβ therapies to pass clinical tests in sporadic AD points to the complexity of the disease and indicates that earlier or more interventions could be necessary. +4 more findings

• Genetics
• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

CRISPR–Cas9–Mediated Genetic Correction for Alzheimer's Disease A Hypothetical Therapeutic Framework

28/100 ✓ Peer-reviewed Risk genes beyond APOE Zenodo (CERN European Organization for Nuclear Research)

Key finding: The repeated inability of Aβ therapies to pass clinical tests in sporadic AD points to the complexity of the disease and indicates that earlier or more interventions could be necessary. +4 more findings

• Genetics
• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Retinal microvascular alterations reflect cerebral small vessel disease burden in frontotemporal dementia: a multimodal OCTA–MRI Study

45/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer s Research & Therapy

Key finding: FTD patients demonstrated significantly reduced retinal and choriocapillaris perfusion compared to CU (all p < 0.001). +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Virtual reality-based cognitive assessment tools for mild cognitive impairment screening: comparison with traditional paper-and-pencil-based cognitive assessment tools

32/100 ✓ Peer-reviewed Getting a diagnosis Innovation in Aging

Key finding: VARABOM.D scores showed significant positive associations with established cognitive assessments. +4 more findings

• Diagnosis
• Early Stage

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Overcoming Patient Access Barriers in Complex Conditions: Lessons from Schizophrenia for Broader Healthcare Applications

30/100 ✓ Peer-reviewed Health systems and care delivery Journal of Market Access & Health Policy

Key finding: Cognitive impairment associated with schizophrenia (CIAS) illustrates how critical symptom domains are often overlooked despite their impact on long-term outcomes. +1 more finding

• Policy

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Identification of chemicals targeting dementia genes and pathways in the Comparative Toxicogenomics Database

48/100 ✓ Peer-reviewed Risk factors Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: We identified chemicals enriched for dementia pathways, suggesting broad classes of chemicals contribute to dementia. +1 more finding

• Genetics

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Comparing clinical effect sizes of SouvenaidTM, lecanemab, and donanemab in early Alzheimer's disease

45/100 ✓ Peer-reviewed Treatments Journal of Alzheimer's disease : JAD

Key finding: Times of functional independence were estimated using the Hartz approach. +2 more findings

• Treatments

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The Alzheimer's disease risk genes MS4A4A and MS4A6A cooperate to negatively regulate TREM2 and microglia states

45/100 ✓ Peer-reviewed TREM2 and immune genetics Neuron

Key finding: Genetic variations in MS4A4A and MS4A6A Triggering receptor expressed on myeloid cells 2 (TREM2) are linked to the regulation of cerebrospinal-fluid-soluble TREM2 levels and are associated with Alzheimer's disease (AD) risk and progression. +1 more finding

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source