Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 11,976–12,000 of 27,380 studies, newest first · page 480 of 1096.
January 2020 25
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2020-01-21
Obstructive Sleep Apnea in Neurodegenerative Disorders: Current Evidence in Support of Benefit from Sleep Apnea Treatment
39/100 ✓ Peer-reviewed Risk factors Journal of clinical medicine
Key finding: Obstructive sleep apnea (OSA) is a prevalent disorder characterized by recurrent upper airway obstruction during sleep resulting in intermittent hypoxemia and sleep fragmentation. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-01-21
Liraglutide improves memory in obese patients with prediabetes or early type 2 diabetes: a randomized, controlled study
66/100 ✓ Peer-reviewed Drug development International journal of obesity (2005)
Key finding: Liraglutide might slow down memory function decline in diabetic patients in early, and possibly preclinical stages of the disease. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-01-21
Road proximity, air pollution, noise, green space and neurologic disease incidence: a population-based cohort study
58/100 ✓ Peer-reviewed Disparities Environmental health : a global access science source
Key finding: This association may be partially mediated by air pollution, whereas noise exposure did not affect associations.
Full summary, score breakdown and related studies → Original source
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2020-01-21
Better stress coping associated with lower tau in amyloid-positive cognitively unimpaired older adults
58/100 ✓ Peer-reviewed Biomarkers Neurology
Key finding: A faster termination of the stress response (higher coping ability) may limit the negative effects of stress on tau deposition. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-01-20
The novel GLP‐1/GIP analogue DA5‐CH reduces tau phosphorylation and normalizes theta rhythm in the icv. STZ rat model of AD
41/100 ✓ Peer-reviewed Drug development Brain and Behavior
Key finding: Our results demonstrate that DA5‐CH has neuroprotective effects in the STZ‐induced animal model and that DA5‐CH has potential to treat neurodegenerative disorders such as AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-01-20
Review of Alterations in Perlecan-Associated Vascular Risk Factors in Dementia
39/100 ✓ Peer-reviewed Vascular contributions International journal of molecular sciences
Key finding: VCID, a comorbidity with diverse etiology in sporadic Alzheimer's disease (AD), is thought to be a major factor that drives the overall clinical burden of dementia.
Full summary, score breakdown and related studies → Original source
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2020-01-20
An Altered Relationship between Soluble TREM2 and Inflammatory Markers in Young Adults with Down Syndrome: A Preliminary Report
44/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of immunology (Baltimore, Md. : 1950)
Key finding: Because TREM2 plays a role in the innate immune response and has been associated with dementia, the hypothesis of this exploratory study was that young adults with DS predementia ( n = 15, mean age = 29.5 y) would exhibit a different relationship between sTREM2 and inflammatory markers in plasma, compared with neurotypical, age-matched controls ( n = 16, mean age = 29.6 y). +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-01-20
Comparing food desert residents with non-food desert residents on grocery shopping behaviours, diet and BMI: results from a propensity score analysis
37/100 ✓ Peer-reviewed Risk factors Public Health Nutrition
Key finding: Residence in a food desert (11·1 %, n 411) was not significantly associated with perceived access to healthy foods, most grocery shopping behaviours or dietary behaviour, but was significantly associated with primarily shopping at a superstore or supercentre v . a large grocery store (OR = 1·32; 95 +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-01-19
Validity, reliability, and psychometric properties of a computerized, cognitive assessment test (Cognivue ® )
64/100 ✓ Peer-reviewed Cognitive tests and assessment World journal of psychiatry
Key finding: Cognivue ® scores ≤ 50 avoid misclassification of impairment, and scores ≥ 75 avoid misclassification of unimpairment. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-01-18
Autophagy modulates Aβ accumulation and formation of aggregates in yeast
39/100 ✓ Peer-reviewed Disease mechanisms Molecular and cellular neurosciences
Key finding: Overall, our findings identify a novel role for these nutrient and stress signalling genes in the targeted elimination of Aβ42 aggregates, which offer a promising avenue for developing autophagy based therapies to suppress amyloid deposition in AD.
Full summary, score breakdown and related studies → Original source
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2020-01-18
Glymphatic System Impairment in Alzheimer's Disease and Idiopathic Normal Pressure Hydrocephalus
51/100 ✓ Peer-reviewed Risk factors Trends in molecular medicine
Key finding: Approximately 10% of dementia patients have idiopathic normal pressure hydrocephalus (iNPH), an expansion of the cerebrospinal fluid (CSF)-filled brain ventricles. iNPH and Alzheimer's disease (AD) both exhibit sleep disturbances, build-up of brain metabolic wastes and amyloid-β (Aβ) plaques, perivascular reactive astrogliosis, and mislocalization of astrocyte aquaporin-4 (AQP4). +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-01-17
Temporal and anatomical distribution of 18F-flutemetamol uptake in canine brain using positron emission tomography
39/100 ✓ Peer-reviewed Brain scans and imaging BMC veterinary research
Key finding: Among the six cerebral cortical regions, the cingulate cortices and frontal lobe showed the highest SUVRs. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-01-17
The progress of gut microbiome research related to brain disorders
41/100 ✓ Peer-reviewed Disease mechanisms Journal of neuroinflammation
Key finding: However, it is now becoming clear that many non-nervous system factors, including the gut-resident bacteria of the gastrointestinal tract, regulate and influence cognitive dysfunction as well as the process of neurodegeneration and cerebrovascular diseases. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-01-17
Functional brain architecture is associated with the rate of tau accumulation in Alzheimer's disease
55/100 ✓ Peer-reviewed Brain scans and imaging Nature communications
Key finding: In Alzheimer's diseases (AD), tau pathology is strongly associated with cognitive decline. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-01-17
The characterisation of subjective cognitive decline
62/100 ✓ Peer-reviewed Mild cognitive impairment The Lancet Neurology
Key finding: The term subjective cognitive decline (SCD) was conceived in 2014 to describe cognitively unimpaired individuals who are concerned that they have reduced cognitive function. +2 more findings
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2020-01-17
Quercetin Alleviates LPS-Induced Depression-Like Behavior in Rats via Regulating BDNF-Related Imbalance of Copine 6 and TREM1/2 in the Hippocampus and PFC
41/100 ✓ Peer-reviewed TREM2 and immune genetics Frontiers in pharmacology
Key finding: The aim of this study was to investigate its effects on the behavioral performance of lipopolysaccharide (LPS)-challenged rats and explore the potential mechanism. +3 more findings
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2020-01-17
The Effect of Hearing Aid Use on Cognition in Older Adults: Can We Delay Decline or Even Improve Cognitive Function?
49/100 ✓ Peer-reviewed Digital health tools Journal of clinical medicine
Key finding: At baseline, multiple linear regression showed hearing loss and age predicted significantly poorer executive function performance, while tertiary education predicted significantly higher executive function and visual learning performance. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-01-17
Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology
52/100 ✓ Peer-reviewed Genetics EMBO molecular medicine
Key finding: We identify in this module 7 established AD risk genes (APOE, CLU, INPP5D, CD33, PLCG2, SPI1, and FCER1G) and 11 AD GWAS genes below the genome-wide significance threshold (GPC2, TREML2, SYK, GRN, SLC2A5, SAMSN1, PYDC1, HEXB, RRBP1, LYN, and BLNK), that become significantly upregulated when exposed to Aβ. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-01-16
Stratifying risk for dementia onset using large-scale electronic health record data: A retrospective cohort study
62/100 ✓ Peer-reviewed Digital health tools Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: A cognitive symptom measure identified in discharge notes facilitated stratification of risk for dementia up to 8 years before diagnosis. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-01-16
Plasma biomarkers of astrocytic and neuronal dysfunction in early- and late-onset Alzheimer's disease
41/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Principle component analyses identified 3 factors: trophic (BDNF, VEGF, TGFβ), degenerative (GFAP, NfL), and inflammatory (TNFα, IL-6, IP-10, IL-10). +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-01-16
Systematic review of genetic association studies in people with Lewy body dementia
54/100 ✓ Peer-reviewed TREM2 and immune genetics International journal of geriatric psychiatry
Key finding: Eight thousand five hundred twenty-one articles were screened, and 75 articles were eligible to be included. +1 more finding
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2020-01-16
Effects of a combined transcranial magnetic stimulation (TMS) and cognitive training intervention in patients with Alzheimer's disease
77/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: This clinical trial evaluates the efficacy and safety of a 6-week course of daily neuroAD™ therapy. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-01-16
Choroid plexus volume is associated with levels of CSF proteins: relevance for Alzheimer's and Parkinson's disease
54/100 ✓ Peer-reviewed Mild cognitive impairment Neurobiology of aging
Key finding: We found negative associations between ChP volume and CSF proteins, which were stronger in healthy controls, early-MCI patients, and PD patients compared with late-MCI and AD patients. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-01-15
Polysomnographic assessment of suvorexant in patients with probable Alzheimer's disease dementia and insomnia: a randomized trial
84/100 ✓ Peer-reviewed Risk factors Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Of 285 participants randomized (suvorexant, N = 142; placebo, N = 143), 277 (97%) completed the trial (suvorexant, N = 136; placebo, N = 141). +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-01-14
TDP-43 and Limbic-Predominant Age-Related TDP-43 Encephalopathy
39/100 ✓ Peer-reviewed Brain tissue and pathology Frontiers in aging neuroscience
Key finding: LATE is perhaps best characterized by the presence of hyperphosphorylated TDP-43, which plays multi-functional roles through interactions with DNA and RNA, leading to significant alterations in the transcription and translation of particular genes.
Full summary, score breakdown and related studies → Original source
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