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46/100

✓ Peer-reviewed alzhub usefulness score 46 out of 100. Brain scans and imaging

Topic: Brain proteins, microglia and lab models

Test-retest analyses demonstrated low variability in flortaucipir F 18 SUVR. The SD of mean percentage change between test and retest using the PERSI reference region was 2.22% for a large posterior neocortical VOI, 1.84% for MUBADA, 1.46% for frontal, 1.98% for temporal, 2.28% for parietal, and 3.27% for occipital VOIs. Further, significant correlations ( R 2 > 0.85; P Significant test-retest reproducibility for flortaucipir F 18 was found across neocortical and mesial temporal lobe structures. These preliminary data suggest that flortaucipir F 18 tau imaging could be used to examine changes in tau burden over time.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Devous, M. D., Joshi, A. D., Navitsky, M., Southekal, S., Pontecorvo, M. J., Shen, H., et al. (2018). Test-Retest Reproducibility for the Tau PET Imaging Agent Flortaucipir F 18. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. https://doi.org/10.2967/jnumed.117.200691

Vancouver

Devous MD, Joshi AD, Navitsky M, Southekal S, Pontecorvo MJ, Shen H, et al. Test-Retest Reproducibility for the Tau PET Imaging Agent Flortaucipir F 18. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2018. doi:10.2967/jnumed.117.200691. PMID: 29284675.

BibTeX

@article{devous2018-29284675,
  author  = {Devous, M. D. and Joshi, A. D. and Navitsky, M. and Southekal, S. and Pontecorvo, M. J. and Shen, H. and Lu, M. and Shankle, W. R. and others},
  title   = {{Test-Retest Reproducibility for the Tau PET Imaging Agent Flortaucipir F 18}},
  journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year    = {2018},
  doi     = {10.2967/jnumed.117.200691},
  pmid    = {29284675},
  url     = {https://doi.org/10.2967/jnumed.117.200691}
}

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Key findings

Test-retest analyses demonstrated low variability in flortaucipir F 18 SUVR.
The SD of mean percentage change between test and retest using the PERSI reference region was 2.22% for a large posterior neocortical VOI, 1.84% for MUBADA, 1.46% for frontal, 1.98% for temporal, 2.28% for parietal, and 3.27% for occipital VOIs.
Further, significant correlations ( R 2 > 0.85; P Significant test-retest reproducibility for flortaucipir F 18 was found across neocortical and mesial temporal lobe structures.
These preliminary data suggest that flortaucipir F 18 tau imaging could be used to examine changes in tau burden over time.

Why it matters

This test-retest study found that the tau PET imaging agent flortaucipir F 18 had low variability across brain regions, suggesting it could be used to examine changes in tau burden over time. It is a technical imaging study, not a test of treating, curing, or preventing Alzheimer's disease.

New to this subject? Start with our plain-English guide: Brain scans & tests →

Study details

Effect size2.22%; 1.84%; 1.46%
Evidence strengthLow

How this study scored 46/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of nuclear medicine : official publication, Society of Nuclear Medicine)
Journal's citation record	2 / 4	Journal of Nuclear Medicine: journal h-index 230 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2018 — within 10 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	4 / 7	Cited 80 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	8.0 citations a year over 10 year(s) since 2018
Impact for its field and year	3 / 6	Cited 4.0× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	3 / 6	Cited by 14 other studies in this library
Still being cited	2 / 4	Cited 26 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Mark A. Mintun: h-index 131 (OpenAlex, whole career)
Institution's track record	0 / 3	Avid Radiopharmaceuticals (United States): institution h-index 190 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 2 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 29284675)
Free to read	0 / 2	Behind a paywall — scores zero
Total	46 / 100	—

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