Newest studies

The Role and Future Potential of Radio, Podcasts, and YouTube in Influencing Awareness and Policy on Neurodegenerative Diseases in the Arab Gulf: A Focus on Oman, Qatar, UAE, and Saudi Arabia

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors Preprints.org

Key finding: It concludes that effective communication channels that build on existing cultural and social factors show promise for informing and increasing health awareness of NDs, but evidence is still lacking to show that receiving information alone affects health or policy.

• Policy

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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The Effect of Noncontingent Monetary Incentives in Recruitment Letters on Research Enrollment of Alzheimer’s Disease and Related Dementia Caregiving Dyads: A Study Within a Trial (SWAT) Randomized Controlled Trial

16/100 ⚠ Preprint — not yet peer-reviewed Clinical trials Research Square

Key finding: In this trial, $5 and $25 noncontingent monetary incentives included in mailed recruitment letters did not produce a detectable improvement in response among ADRD caregiving dyads. +3 more findings

• Clinical Trials
• Caregiving

Scored 60 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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In Vivo Transcriptomics-Based Framework for Systematic Indication Expansion

16/100 ⚠ Preprint — not yet peer-reviewed Drug development bioRxiv

Key finding: We applied this framework to semaglutide, a GLP-1 receptor agonist originally developed for diabetes and subsequently expanded for several other indications. +4 more findings

• Treatments

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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The effects of Arf4 gene knockdown on Alzheimer's amyloid β deposition: Possible role in cognitive resilience

16/100 ⚠ Preprint — not yet peer-reviewed Risk genes beyond APOE Research Square

Key finding: Based on the exacerbated AD pathological features and transcriptomic alterations observed in Arf4 knockdown animals, ARF4 appears to play a critical role in AD resilience and may represent a potential prognostic factor worthy of further investigation. +4 more findings

• Genetics
• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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The modulatory effects of Hericium erinaceus and donepezil on amyloid accumulation and autophagy-associated clearance in Aβ 1-42 -induced N2a cells

16/100 ⚠ Preprint — not yet peer-reviewed Risk genes beyond APOE bioRxiv

Key finding: These integrated findings support H. erinaceus as a candidate adjunct to donepezil, with possible complementary effects on amyloidogenic processing and intracellular clearance. +2 more findings

• Treatments
• Brain Biology

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Endothelial CD36 links arteriolar remodeling to metabolic and immune alterations in Alzheimer’s disease

16/100 ⚠ Preprint — not yet peer-reviewed Risk genes beyond APOE bioRxiv

Key finding: In complementary mouse studies, endothelial PKD1 deficiency was accompanied by increased vascular CD36 and cerebrovascular abnormalities, whereas endothelial CD36 deletion altered lipid-metabolic and innate-immune-associated transcriptional programs, including AD-relevant genes and pathways, under metabolic-inflammatory stress. +4 more findings

• Genetics
• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Transcriptomic and phenotypic characterization of Alzheimer’s disease risk genes in neurons and astrocytes highlights shared and cell type specific cellular mechanisms

16/100 ⚠ Preprint — not yet peer-reviewed Genetics bioRxiv

Key finding: We observed that disease-linked expression programs previously identified from postmortem patient samples responded to candidate gene knockouts, suggesting that our cells can model disease-relevant mechanisms, and highlighting candidate genes that perturb these. +2 more findings

• Genetics
• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Cerebrospinal fluid dopa-decarboxylase is a biomarker of dopaminergic dysfunction

16/100 ⚠ Preprint — not yet peer-reviewed Tau biomarkers medRxiv

Key finding: CSF DDC reflects nigrostriatal dopaminergic dysfunction, representing a potential quantitative biochemical alternative to DaT-SPECT that might be readily implemented via automated immunoassays. +1 more finding

• Biomarkers
• Other Dementias

Scored 37 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Vision Impairment, Vision Correction, and Dementia Risk in Mild Cognitive Impairment

45/100 ✓ Peer-reviewed Risk factors Journal of the American Geriatrics Society

Key finding: Among individuals with mild cognitive impairment, no vision impairment (VI) and corrected VI were associated with a lower risk of dementia than uncorrected VI, particularly among those aged < 75 years.

• Risk Factors
• Early Stage

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Enhancing Neurodegeneration Awareness and Care for the Elderly in Saudi Arabia, UAE, Oman, and Qatar: Challenges, Policy Gaps, and Future Directions

16/100 ⚠ Preprint — not yet peer-reviewed How common it is Preprints.org

Key finding: These results suggest that there may be room to enhance screening, referrals, and health literacy through increased coverage by mainstream media, collaborations with religious and community organizations, and broader implementation of telemedicine.

• Policy
• Digital Tools

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Dementia and PDE5 inhibitors: A retrospective cohort study of veterans

16/100 ⚠ Preprint — not yet peer-reviewed Lewy body dementia Research Square

Key finding: The observed protective effect may be explained by vascular and neuroprotective mechanisms unique to PDE5 inhibitors. +3 more findings

• Other Dementias

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Short-Horizon Metrics and the Persistence of Capacity-Debiting Practices in Nursing Homes

16/100 ⚠ Preprint — not yet peer-reviewed Clinical safety Preprints.org

Key finding: Drawing on the quality-measurement, staffing, and physiological literatures, it derives four mechanisms from the structure of existing long-stay measures and current staffing conditions: timescale and attribution asymmetry, threshold-based detection, measurement of state rather than trajectory, and staffing scarcity. +4 more findings

• Care Services

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Neuroprotective Effects and Mechanisms of Cannabinoids in In Vitro Cell Models of Neurodegenerative Diseases: A Scoping Review

16/100 ⚠ Preprint — not yet peer-reviewed Disease mechanisms Research Square

Key finding: Most included studies were purely in vitro (n = 18); six combined in vitro and in vivo methods, and two used in vitro and in silico or ex vivo components.

• Brain Biology

Scored 23 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Intrastriatal injection of amplified Lewy body dementia (LBD) fibrils in mice results in accumulation of fibrils with LBD structure and neurodegeneration

16/100 ⚠ Preprint — not yet peer-reviewed Brain tissue and pathology bioRxiv

Key finding: High resolution 3D structural information could not be obtained because of the lack of helical twist, but comparison of the cryo-EM 2D class averages with those derived from amplified fibrils prepared from human LBD tissue revealed multiple matching classes, indicating that the Lewy fold is maintained in the fibrils that accumulate in mouse brain tissue. +1 more finding

• Brain Biology
• Other Dementias

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Visit-to-Visit Blood Pressure Variability, Glycemic Status and the Risk of Dementia, Stroke, and All-Cause Mortality: A UK Biobank Cohort Study

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors medRxiv

Key finding: Absolute BPV was associated with mortality, and DBP and MAP variability with overall stroke, after accounting for glycemic status and mean blood pressure. +4 more findings

• Risk Factors

Scored 52 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Oligodendrocyte stress response as a driver of vascular dementia

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors bioRxiv

Key finding: Together, these findings reveal a critical, cell-autonomous role for oligodendroglial ISR activation during cerebrovascular stress and position this pathway as a viable therapeutic target to mitigate VaD pathogenesis.

• Other Dementias

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Progranulin deficiency promotes neuroinflammation through cathepsin B-mediated activation of the NLRP3 inflammasome

16/100 ⚠ Preprint — not yet peer-reviewed Drug development bioRxiv

Key finding: Studies in progranulin-deficient mouse models have demonstrated the critical role of neuroinflammation in disease pathogenesis, as deletion of NF-kB or complement factors prevents FTD-associated behavioral deficits. +4 more findings

• Brain Biology
• Treatments
• Genetics

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Neurodegenerative disorders: Stereotyped relationships between pathological metabolic topographies and the healthy default mode network

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging Research Square

Key finding: The disorders fell into one of three categories based on the topographic relationship of the disease-specific and healthy networks. +4 more findings

Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Information-Theoretic Geometry HCFIM features for data-limited EEG screening of Alzheimer’s disease and Frontotemporal Dementia

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging Research Square

Key finding: These results support HCFIM as an interpretable, reproducible complement to spectral EEG features for preclinical methodological research, while emphasizing the need for independent validation before clinical or device-specific claims.

• Diagnosis
• Other Dementias

Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Normative transcriptomic clues to thalamic developmental vulnerability in C9orf7 2-FTLD

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging medRxiv

Key finding: This study investigated volumetric MRI differences of the thalamic nuclei in asymptomatic young adult C9orf72 expansion carriers compared to non-carriers, and examined spatial associations with normative thalamic transcriptomics from 8 weeks post-conception through middle age. +2 more findings

• Other Dementias

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Location-specific Longitudinal Patterns of Subcortical and Lobar Cerebral Microhemorrhages in Preclinical Alzheimer Disease

16/100 ⚠ Preprint — not yet peer-reviewed Genetics medRxiv

Key finding: Emerging evidence and expert opinion suggest that subcortical microhaemorrhages may be less closely related to cerebral amyloidosis than lobar lesions and may therefore warrant separate consideration in anti-amyloid treatment eligibility criteria. +4 more findings

Scored 50 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Turbulent dynamics and in silico perturbation-based measures are disrupted across biological stages of Alzheimers disease

16/100 ⚠ Preprint — not yet peer-reviewed Genetics medRxiv

Key finding: Large-scale turbulence was associated with all three AT(N) components. +3 more findings

• Genetics

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Blood Plasma Coenzyme Q 10 and P-Selectin Are Predictive Factors for Mild Cognitive Dysfunction in Elderly Women

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers Preprints.org

Key finding: High levels of Coenzyme Q10 (CoQ10) in plasma are associated with high cognitive and executive capacities. +2 more findings

• Biomarkers

Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Presymptomatic plasma biomarkers in autosomal dominant Alzheimer's disease: sequence and timing

70/100 ✓ Peer-reviewed Biomarkers Journal of neurology, neurosurgery, and psychiatry

Key finding: Nine proteins (amyloid-beta 42 (Aβ42), beta-secretase 1 (BACE1), glial fibrillary acidic protein (GFAP), pTau181, pTau231, pTau217, t0tal tau (MAPT), neurofilament light (NfL) and acetylcholinesterase (AChE)) robustly differed between carriers and non-carriers cross-sectionally. +4 more findings

• Biomarkers
• Genetics

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Speaker-Attributed Transcription Toward Automated Scoring of NACC Uniform Data Set Assessments: A Whisper–Pyannote Pipeline and Pilot Evaluation

16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools Preprints.org

Key finding: Error analysis showed that a single deleted response would produce at least two incorrect item codes if responses were assigned to items in order of occurrence, so WER alone does not capture clinical utility.

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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