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Associations between sleep disturbance and cerebrospinal fluid Aβ, and shared proteomic signatures in Alzheimer's disease
Tianbai Li, Meichen Liu, Peng Zhang, Song Li, Tao Qiu, Xinhui Qiu, Bo Sun, Huaibin Cai et al.. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026-04
Topic: Genetics and APOE
Baseline sleep disturbance was associated with a faster rate of longitudinal CSF Aβ42 decline. WGCNA identified a protein module associated with sleep disturbance and Aβ42, within which MR supported effects of sleep disturbance on multiple proteins. Among these, interferon γ-inducible protein 16 is a candidate link between sleep disturbance and Aβ pathology. Our findings suggest that sleep disturbance accelerates Aβ pathology, and implicate IFI16-related pathway as a link between disrupted sleep and AD progression.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Li, T., Liu, M., Zhang, P., Li, S., Qiu, T., Qiu, X., et al. (2026). Associations between sleep disturbance and cerebrospinal fluid Aβ, and shared proteomic signatures in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1002/alz.71316
Vancouver
Li T, Liu M, Zhang P, Li S, Qiu T, Qiu X, et al. Associations between sleep disturbance and cerebrospinal fluid Aβ, and shared proteomic signatures in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2026. doi:10.1002/alz.71316. PMID: 41912985.
BibTeX
@article{li2026-41912985,
author = {Li, Tianbai and Liu, Meichen and Zhang, Peng and Li, Song and Qiu, Tao and Qiu, Xinhui and Sun, Bo and Cai, Huaibin and others},
title = {{Associations between sleep disturbance and cerebrospinal fluid Aβ, and shared proteomic signatures in Alzheimer's disease}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2026},
doi = {10.1002/alz.71316},
pmid = {41912985},
url = {https://doi.org/10.1002/alz.71316}
}
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Key findings
- Baseline sleep disturbance was associated with a faster rate of longitudinal CSF Aβ42 decline.
- WGCNA identified a protein module associated with sleep disturbance and Aβ42, within which MR supported effects of sleep disturbance on multiple proteins.
- Among these, interferon γ-inducible protein 16 is a candidate link between sleep disturbance and Aβ pathology.
- Our findings suggest that sleep disturbance accelerates Aβ pathology, and implicate IFI16-related pathway as a link between disrupted sleep and AD progression.
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Study details
- Study designlongitudinal study
- Participants1,205
- Evidence strengthModerate
How this study scored 75/100
Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 42 of the 56 points we could judge it on, which is 75 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,205 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41912985) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 42 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 42 of the 56 points we could judge it on is 75 out of 100. |
| Total | 75 / 100 | — |
What each of these 20 components measures, and what this score is not →
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