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Combining p-tau217 and digital cognitive testing to predict cognitive decline
Hairin Kim, Daniel Soberanes, Roos J Jutten, Mark A Dubbelman, Hyun-Sik Yang, Gad A Marshall, Keith A Johnson, Rebecca A Betensky et al.. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026-04
Topic: Brain imaging, connectivity and assessment
Adding MDLC to p-tau217 significantly explained longitudinal cognitive trajectory beyond p-tau217 alone. Although higher p-tau217 and lower MDLC were independently associated with steeper decline, individuals with both risk factors declined the fastest. Notably, those with elevated p-tau217 level but preserved MDLC remained stable, distinguishing them from those at imminent risk. Combining digital learning metrics with plasma p-tau217 enables precise risk stratification. This approach identifies individuals most vulnerable to imminent decline, potentially enhancing screening for early preventive interventions.
Key findings
- Adding MDLC to p-tau217 significantly explained longitudinal cognitive trajectory beyond p-tau217 alone.
- Although higher p-tau217 and lower MDLC were independently associated with steeper decline, individuals with both risk factors declined the fastest.
- Notably, those with elevated p-tau217 level but preserved MDLC remained stable, distinguishing them from those at imminent risk.
- Combining digital learning metrics with plasma p-tau217 enables precise risk stratification.
- This approach identifies individuals most vulnerable to imminent decline, potentially enhancing screening for early preventive interventions.
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Study details
- Study designlongitudinal study
- Participants183
- Evidence strengthModerate
How this study scored 73/100
Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 41 of the 56 points we could judge it on, which is 73 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 2 / 4 | 183 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41913058) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 41 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 41 of the 56 points we could judge it on is 73 out of 100. |
| Total | 73 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Kim, H., Soberanes, D., Jutten, R. J., Dubbelman, M. A., Yang, H.-S., Marshall, G. A., et al. (2026). Combining p-tau217 and digital cognitive testing to predict cognitive decline. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1002/alz.71328
Vancouver
Kim H, Soberanes D, Jutten RJ, Dubbelman MA, Yang H.-S, Marshall GA, et al. Combining p-tau217 and digital cognitive testing to predict cognitive decline. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2026. doi:10.1002/alz.71328. PMID: 41913058.
BibTeX
@article{kim2026-41913058,
author = {Kim, Hairin and Soberanes, Daniel and Jutten, Roos J and Dubbelman, Mark A and Yang, Hyun-Sik and Marshall, Gad A and Johnson, Keith A and Betensky, Rebecca A and others},
title = {{Combining p-tau217 and digital cognitive testing to predict cognitive decline}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2026},
doi = {10.1002/alz.71328},
pmid = {41913058},
url = {https://doi.org/10.1002/alz.71328}
}