Home › Research › Mild cognitive impairment
Mild cognitive impairment‐to‐Alzheimer's dementia progression risk: the contribution of the Interceptor project
Flavia Lucia Lombardo, Naike Caraglia, Patrizia Lorenzini, Nicola Vanacore, Stefano Francesco Cappa, Maria Cotelli, Francesco Iodice, Camillo Marra et al.. Alzheimer s & Dementia, 2026-04-01
Topic: Risk, prevention and care in population studies
Dementia developed in 104 individuals (29.6%), including 85 (22.4%) who met core clinical criteria for probable and possible Alzheimer's disease dementia. A Cox model combining clinical and sociodemographic data achieved a concordance index of 72%, which increased to 82% when neuropsychology and biomarkers were added. The INTERCEPTOR nomogram represents a tool for predicting dementia progression risk, supporting public health strategies, including screening for risk assessment and risk/benefit ratio in innovative treatments.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Lombardo, F. L., Caraglia, N., Lorenzini, P., Vanacore, N., Cappa, S. F., Cotelli, M., et al. (2026). Mild cognitive impairment‐to‐Alzheimer's dementia progression risk: the contribution of the Interceptor project. Alzheimer s & Dementia. https://doi.org/10.1002/alz.71204
Vancouver
Lombardo FL, Caraglia N, Lorenzini P, Vanacore N, Cappa SF, Cotelli M, et al. Mild cognitive impairment‐to‐Alzheimer's dementia progression risk: the contribution of the Interceptor project. Alzheimer s & Dementia. 2026. doi:10.1002/alz.71204. PMID: 41949058.
BibTeX
@article{lombardo2026-41949058,
author = {Lombardo, Flavia Lucia and Caraglia, Naike and Lorenzini, Patrizia and Vanacore, Nicola and Cappa, Stefano Francesco and Cotelli, Maria and Iodice, Francesco and Marra, Camillo and others},
title = {{Mild cognitive impairment‐to‐Alzheimer's dementia progression risk: the contribution of the Interceptor project}},
journal = {Alzheimer s \& Dementia},
year = {2026},
doi = {10.1002/alz.71204},
pmid = {41949058},
url = {https://doi.org/10.1002/alz.71204}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Dementia developed in 104 individuals (29.6%), including 85 (22.4%) who met core clinical criteria for probable and possible Alzheimer's disease dementia.
- A Cox model combining clinical and sociodemographic data achieved a concordance index of 72%, which increased to 82% when neuropsychology and biomarkers were added.
- The INTERCEPTOR nomogram represents a tool for predicting dementia progression risk, supporting public health strategies, including screening for risk assessment and risk/benefit ratio in innovative treatments.
Why it matters
In this study, 29.6% of participants developed dementia, and a model combining clinical and sociodemographic data predicted progression with 72% accuracy, rising to 82% when neuropsychology and biomarkers were added. The resulting INTERCEPTOR nomogram is presented as a tool for predicting dementia progression risk to support screening and risk assessment, not as a treatment or cure.
Study details
- Participants398
- Effect size29.6%; 22.4%
- Evidence strengthLow
How this study scored 46/100
Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 44 of the 96 points we could judge it on, which is 46 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 2 / 4 | 398 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 1 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.5 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | 3 / 6 | Cited 4.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | OpenAlex's profile for last-listed author the INTERCEPTOR Network holds only 1 work(s), too few to judge a track record — left out of this score |
| Institution's track record | 1 / 3 | IRCCS Ospedale San Raffaele: institution h-index 731 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 13 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41949058) |
| Free to read | 2 / 2 | Free to read |
| Points | 44 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 44 of the 96 points we could judge it on is 46 out of 100. |
| Total | 46 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Related
Studies in the library that share something with this one. The line above each title says what.
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here. Showing 12 of 15.
Related studies in Mild cognitive impairment
Also tagged “mini-mental”
840 studies in the library carry the topic tag “mini-mental”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 840 tagged studies.