Geographic Variation in ADRD… | 2026

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38/100

✓ Peer-reviewed alzhub usefulness score 38 out of 100. Risk factors

Topic: Risk, prevention and care in population studies

Counties had a mean prevalence of 65.3 per 1,000 (SD 15.5) for highly likely ADRD and 123.5 per 1,000 (SD 27.0) for all determinations. The mean all-cause mortality rate among ADRD cases was 22.1 per 1,000 (SD 6.6). Hotspot analysis revealed significant high-prevalence and high-mortality clusters in the South, with cold spots in the Mountain West and Upper Midwest. MGWR results indicate that higher county-level social vulnerability was significantly associated with higher ADRD prevalence (overall β range ≈ 0.42-1.87; 95% CI: 0.31-1.98) and mortality (β range ≈ 0.55-2.12; 95% CI: 0.44-2.26), with the strongest, most spatially consistent effects observed for mortality. The magnitude and direction of associations varied regionally, with the largest positive effects in the South, Southwest, and West. Substantial geographic disparities exist in ADRD prevalence and mortality, with disproportionately higher burdens in socially vulnerable counties. Social vulnerability, particularly socioeconomic disadvantage, is strongly and spatially heterogenously associated with ADRD outcomes, underscoring the importance of targeted public health and policy interventions in high-burden, high-vulnerability regions.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Kyne, D. (2026). Geographic Variation in ADRD Prevalence and Mortality and Their Association with Social Vulnerability across US Counties: A Spatial Epidemiological Analysis Using NORC and CDC SVI Data. Dementia and Geriatric Cognitive Disorders Extra. https://doi.org/10.1159/000550830

Vancouver

Kyne D. Geographic Variation in ADRD Prevalence and Mortality and Their Association with Social Vulnerability across US Counties: A Spatial Epidemiological Analysis Using NORC and CDC SVI Data. Dementia and Geriatric Cognitive Disorders Extra. 2026. doi:10.1159/000550830. PMID: 42221521.

BibTeX

@article{kyne2026-42221521,
  author  = {Kyne, Dean},
  title   = {{Geographic Variation in ADRD Prevalence and Mortality and Their Association with Social Vulnerability across US Counties: A Spatial Epidemiological Analysis Using NORC and CDC SVI Data}},
  journal = {Dementia and Geriatric Cognitive Disorders Extra},
  year    = {2026},
  doi     = {10.1159/000550830},
  pmid    = {42221521},
  url     = {https://doi.org/10.1159/000550830}
}

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Key findings

Counties had a mean prevalence of 65.3 per 1,000 (SD 15.5) for highly likely ADRD and 123.5 per 1,000 (SD 27.0) for all determinations.
The mean all-cause mortality rate among ADRD cases was 22.1 per 1,000 (SD 6.6).
Hotspot analysis revealed significant high-prevalence and high-mortality clusters in the South, with cold spots in the Mountain West and Upper Midwest.
MGWR results indicate that higher county-level social vulnerability was significantly associated with higher ADRD prevalence (overall β range ≈ 0.42-1.87; 95% CI: 0.31-1.98) and mortality (β range ≈ 0.55-2.12; 95% CI: 0.44-2.26), with the strongest, most spatially consistent effects observed for mortality.
The magnitude and direction of associations varied regionally, with the largest positive effects in the South, Southwest, and West.

Why it matters

This spatial epidemiological analysis found that county-level social vulnerability was linked to higher ADRD prevalence and mortality across US counties. It does not test any treatment, cure, or prevention for Alzheimer's disease.

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Study details

Study designcross-sectional
Participants3,108
Evidence strengthLow

How this study scored 38/100

Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Dementia and Geriatric Cognitive Disorders Extra)
Journal's citation record	0 / 4	Dementia and Geriatric Cognitive Disorders Extra: journal h-index 52 (OpenAlex, 2026-10-29)
Study design	4 / 12	A snapshot of people at one point in time
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	5 / 5	2026 — within 1 year(s) of the newest study here
Sample size	3 / 4	3,108 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	0 / 7	Cited 0 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.0 citations a year over 2 year(s) since 2026
Impact for its field and year	0 / 6	Cited 0.0× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	1 / 4	Last-listed author Dean Kyne: h-index 9 (OpenAlex, whole career)
Institution's track record	0 / 3	The University of Texas Rio Grande Valley: institution h-index 484 (OpenAlex)
Multi-centre collaboration	0 / 3	OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete)
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 42221521)
Free to read	2 / 2	Free to read
Total	38 / 100	—

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