Newest studies

Predicting Cognitive Function Using Transformer-Derived Speech Representations and Longitudinal Coherence Features

16/100 ⚠ Preprint — not yet peer-reviewed Cognitive tests and assessment medRxiv

Key finding: Ablation analysis demonstrated that transformer-derived speech representations provided complementary predictive information beyond clinical variables. +1 more finding

• Diagnosis

Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

The Chilean harmonized cognitive assessment protocol (Chile-Cog): study design

53/100 ✓ Peer-reviewed Getting a diagnosis BMC Public Health

Key finding: Chile-Cog is a significant advancement in assessing cognitive functioning among older Chileans.

• Diagnosis

Full summary, score breakdown and related studies → Original source

Head-to-head comparison of plasma biomarker assays across platforms for amyloid pathology in a multicenter cohort

52/100 ✓ Peer-reviewed Biomarkers 中国科学通报：英文版

Key finding: Several plasma p-tau217 assays demonstrated strong diagnostic accuracy for amyloid PET positivity in this cross-sectional memory-clinic cohort, although performance varied across platforms and cutoff transferability was limited.

• Biomarkers

Full summary, score breakdown and related studies → Original source

The prognostic significance of distinct psychosis symptom profiles in dementia: A cohort study using linked electronic health records

16/100 ⚠ Preprint — not yet peer-reviewed Health systems and care delivery Research Square

Key finding: The prognostic significance of psychosis in dementia differs by symptom profile. +3 more findings

• Care Services

Scored 44 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Multivariate blood biomarkers capture resilience and resistance phenotypes across the Alzheimer’s disease spectrum

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging medRxiv

Key finding: Proteomic, cytokine, and polygenic profiling further distinguished resistance through an APOE-centred genomic signature and resilience through neuroinflammatory markers associated with progression toward clinical Alzheimer’s disease. +1 more finding

• Biomarkers
• Genetics

Scored 37 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

The TREM2 targeting small molecule Sob-AM2 improves cognition independent of Aβ plaque alteration in 5xFAD mice

16/100 ⚠ Preprint — not yet peer-reviewed TREM2 and immune genetics bioRxiv

Key finding: These results suggest that the cognitive-enhancing effects of Sob-AM2 are not the result of reduced overall plaque burden. +2 more findings

• Brain Biology
• Genetics
• Treatments

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Apoptosis protein markers in comorbid type 2 diabetes mellitus and depression; relationships with cognitive performance, incident dementia, and white matter hyperintensities

50/100 ✓ Peer-reviewed Vascular contributions Journal of Affective Disorders

Key finding: Among 60 apoptosis-related proteins identified by Kyoto Encyclopedia of Genes and Genomes pathway enrichment, 41 were significantly up-regulated in comorbid T2DM + MDD relative to controls, and 4 were higher in the comorbid group than both T2DM alone and MDD alone. +3 more findings

• Risk Factors
• Brain Scans

Full summary, score breakdown and related studies → Original source

BIOMARCADORES BIOQUÍMICOS EMERGENTES PARA EL DIAGNÓSTICO TEMPRANO DE ENFERMEDADES NEURODEGENERATIVAS: REVISIÓN SISTEMÁTICA

27/100 ✓ Peer-reviewed Tau biomarkers Revista Politécnica de la Ciencia

Key finding: Se realizó una revisión sistemática de la literatura siguiendo las recomendaciones PRISMA 2020, mediante la búsqueda de estudios publicados entre 2021 y 2026 en PubMed/MEDLINE, Scopus, Web of Science, ScienceDirect y SpringerLink. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

An efficient hybrid quantum machine learning framework for Alzheimer classification

31/100 ✓ Peer-reviewed Brain scans and imaging Scientific Reports

Key finding: Effect size analysis proves the fact that the hybrid model produces statistically significant performance, as well as cases of clinically meaningful improvements over lightweight CNN baselines. +2 more findings

Full summary, score breakdown and related studies → Original source

Eligibility for Anti-Amyloid Therapies in Patients With Biomarker-Confirmed Atypical Alzheimer Disease Phenotypes

44/100 ✓ Peer-reviewed Treatments Neurology

Key finding: = 0.036), with lower scores in PCA and lvPPA (median 21 and 21, respectively) compared with CBS-AD (median 27). +4 more findings

• Treatments

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Antemortem α-Synuclein levels from neuron-derived extracellular vesicles identify Lewy Body pathology in Parkinson’s Disease and Alzheimer Disease

16/100 ⚠ Preprint — not yet peer-reviewed Tau biomarkers medRxiv

Key finding: These aggregated proteins contribute to the pathological and clinical heterogeneity of AD and are associated with a more rapid progression. +3 more findings

• Other Dementias
• Biomarkers
• Brain Biology

Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Bilingualism and Cognitive Aging in Ethnically Diverse Older Adults: Cross-sectional and Longitudinal Evidence from HABS-HD

62/100 ✓ Peer-reviewed Disparities The journals of gerontology. Series B, Psychological sciences and social sciences

Key finding: This study examined whether bilingualism is associated with dementia status and longitudinal cognitive decline, and whether associations vary by ethnicity or gender. +4 more findings

• Health Equity

Full summary, score breakdown and related studies → Original source

Gut microbiota mediates the association between aging and cognitive function: evidence from a population-based Kyotango study linking diet, Bifidobacterium, and Mini-Mental State Examination (MMSE) score

16/100 ⚠ Preprint — not yet peer-reviewed Disease mechanisms Research Square

Key finding: Our findings provide evidence that age-related changes in the gut microbiota, particularly reductions in Bifidobacterium , partially mediate cognitive decline in older adults. +4 more findings

• Diagnosis
• Lifestyle

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Investigating the Causal Relationship between Neuroticism and Alzheimer’s Disease Using Mendelian Randomization and the Mediating Role of Modifiable Risk Factors

16/100 ⚠ Preprint — not yet peer-reviewed Prevention and risk medRxiv

Key finding: Neuroticism, a personality trait characterized by the predisposition to experience intense and frequent negative emotions, has been associated with an increased risk of Alzheimer’s disease (AD). +4 more findings

• Prevention
• Risk Factors
• Genetics

Scored 34 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Educational attainment and sex modulate clinical outcomes in genetic frontotemporal dementia

61/100 ✓ Peer-reviewed Risk factors Brain communications

Key finding: Female participants showed a weaker association between disease stage and cognitive performance compared to males (P < 0.001), with difference becoming progressively more pronounced across symptomatic stages. +4 more findings

• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

Cognitive and Biomarker Signatures of Late-Onset Temporal Lobe Epilepsy: Toward Non-Alzheimer Neurodegenerative Mechanisms

53/100 ✓ Peer-reviewed Tau biomarkers Neurology

Key finding: Late-onset unexplained epilepsy (LOUE) represents a substantial proportion of epilepsies with onset after 50 years and often manifests as temporal lobe epilepsy (LO-TLE). +3 more findings

• Biomarkers

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Incidence of dementia after age 90 years and association with APOE genotype, race, and sex in the USA: the LifeAfter90 prospective cohort study

55/100 ✓ Peer-reviewed How common it is The lancet. Healthy longevity

Key finding: In Fine-Gray models, dementia risk was higher in female than in male participants (subdistribution hazard ratio [sHR] 1·89, 95% CI 1·30-2·76) and Black than Asian participants (sHR 1·75, 1·07-2·88), lower in APOE ε2 carriers than in non-carriers (sHR 0·39, 0·17-0·88), and not significantly higher in APOE ε4 carriers than in non-carriers (sHR 1·51, 0·92-2·47). +2 more findings

• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

A study on the Mini-cog scale in the general screening of cognitive status among the elderly in Putian city

16/100 ⚠ Preprint — not yet peer-reviewed Cognitive tests and assessment Research Square

Key finding: In dialect-dominant, educationally diverse elderly, Mini-cog provides superior diagnostic accuracy for MCI versus HKBC and MoCA, and comparable accuracy for dementia. +3 more findings

• Diagnosis
• Early Stage

Scored 40 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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An Integrative Multimodal Model for Early Diagnosis of Dementia and Differential Diagnosis of Alzheimer’s Disease Using Neuroimaging, Polygenic Risk, and Cognitive Assessments

16/100 ⚠ Preprint — not yet peer-reviewed Getting a diagnosis medRxiv

Key finding: Multimodal integration of cognitive, neuroimaging, and polygenic data in the MHS-RWD tool yields strong discrimination for both early diagnosis of dementia and AD differential diagnosis. +1 more finding

• Diagnosis
• Brain Scans
• Genetics

Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Distinguishing Apathy from Depression in Dementia: Implications for Diagnosis and Treatment

16/100 ⚠ Preprint — not yet peer-reviewed Getting a diagnosis Preprints.org

Key finding: Although these syndromes frequently overlap in clinical presentation, they represent distinct conditions with different underlying mechanisms and treatment implications. +4 more findings

• Diagnosis
• Treatments

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Regional Cerebrospinal Fluid Motility as a Key Determinant of Soluble Amyloid-β Levels and Kinetics

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging Research Square

Key finding: Higher regional CSF motility was consistently associated with higher CSF Aβ40 concentrations, with convergent voxel-wise and region-of-interest effects across ventricular and extra-axial CSF compartments that were most prominent in peri-Sylvian CSF pathways. +2 more findings

• Biomarkers
• Brain Scans

Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

The Ignite app detects early cognitive impairment and tracks disease severity in genetic frontotemporal dementia

16/100 ⚠ Preprint — not yet peer-reviewed Cognitive tests and assessment Research Square

Key finding: Ignite is a sensitive digital cognitive assessment capable of detecting early cognitive changes in genetic FTD and demonstrates improved discrimination compared with standard neuropsychological measures at milder disease severity. +4 more findings

• Genetics
• Digital Tools

Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Oxidative stress, aging, metabolism, SIRT1, and the gut microbiota: the neurocardiac basis of cognitive loss

45/100 ✓ Peer-reviewed Disease mechanisms Medical gas research

Key finding: Current treatments for cognitive impairment in diseases such as cardiovascular disease, Alzheimer's disease, multiple sclerosis, and diabetes often fail to fully address the shared underlying cellular mechanisms. +4 more findings

• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

Sleep and Neurodegeneration

50/100 ✓ Peer-reviewed Risk factors Continuum (Minneapolis, Minn.)

Key finding: Sleep apnea is associated with an increased risk of Parkinson disease. +1 more finding

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Progranulin deficiency-induced lysosomal dysfunction drives maladaptive myeloid cell states through the MITF/TFE transcription factors

45/100 ✓ Peer-reviewed Genetics Immunity

Key finding: Epigenetic profiling of Grn-/- microglia revealed an enrichment of MITF/TFE transcription factor motifs at active enhancers, and deletion of these factors reversed the Grn-/--specific myeloid cell transcriptional signature. +1 more finding

Full summary, score breakdown and related studies → Original source