Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 26,851–26,875 of 27,380 studies, newest first · page 1075 of 1096.
September 1992 2
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1992-09-01
A comparison of caregivers for elderly stroke and dementia victims
52/100 ✓ Peer-reviewed Caregiving Journal of the American Geriatrics Society
Key finding: Elderly co-resident caregivers for stroke and dementia patients experience similar degrees of burden and high levels of psychological morbidity. +3 more findings
Full summary, score breakdown and related studies → Original source
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1992-09-01
Neuroleptic sensitivity in patients with senile dementia of Lewy body type
52/100 ✓ Peer-reviewed Getting a diagnosis BMJ (Clinical research ed.)
Key finding: Severe, and often fatal, neuroleptic sensitivity may occur in elderly patients with confusion, dementia, or behavioural disturbance. +2 more findings
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August 1992 6
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1992-08-15
Dementia: A Clinical Approach
38/100 ✓ Peer-reviewed Lewy body dementia Annals of Internal Medicine
Key finding: Psychiatric Dementias Associated with Psychiatric Disorders 13.
Full summary, score breakdown and related studies → Original source
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1992-08-01
Hippocampal volumetric and morphometric studies in frontal and temporal lobe epilepsy
53/100 ✓ Peer-reviewed Hippocampus size on brain scans Brain : a journal of neurology
Key finding: Patients with well-lateralized temporal lobe epilepsy (TLE) (n = 20) and well-defined frontal lobe epilepsy (FLE) (n = 20) were studied, and volumes compared with normal values derived from 10 neurologically normal controls. +2 more findings
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1992-08-01
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1992-08-01
Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein
42/100 ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America
Key finding: The A4/beta protein is derived from a larger, transmembrane amyloid precursor protein (APP). +3 more findings
Full summary, score breakdown and related studies → Original source
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1992-08-01
Isolation, characterization, and regional mapping of microclones from a human chromosome 21 microdissection library
29/100 ✓ Peer-reviewed Down syndrome and Alzheimer's American journal of human genetics
Key finding: The mapping results showed that the microclones were unevenly distributed along chromosome 21, with the majority of microclones located in the distal half portion of the long arm, between 21q21.3 and 21qter. +2 more findings
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1992-08-01
Toxoplasmic encephalitis in AIDS
52/100 ✓ Peer-reviewed Getting a diagnosis Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Key finding: Involvement may be closely associated with HIV infection per se, as in the AIDS dementia complex, but is frequently caused by opportunistic pathogens such as Toxoplasma gondii and Cryptococcus neoformans or malignancies such as primary lymphoma of the CNS.
Full summary, score breakdown and related studies → Original source
July 1992 4
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1992-07-01
The Dynamics of Caregiving for a Demented Elder Among Black and White Families
45/100 ✓ Peer-reviewed Disparities Journal of Gerontology
Key finding: A cultural explanation of the more favorable appraisals of Blacks was sought in the caregiving ideology factor, but this dimension was not associated with caregiving outcomes. +1 more finding
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1992-07-01
Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: a magnetic resonance imaging and regional cerebral blood flow study of discordant monozygotic twins
36/100 ✓ Peer-reviewed Hippocampus size on brain scans The American journal of psychiatry
Key finding: This finding is consistent with the notion that schizophrenia involves pathology of and dysfunction within a widely distributed neocortical-limbic neural network that has been implicated in, among other activities, the performance of cognitive tasks requiring working memory. +1 more finding
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1992-07-01
Beta-amyloid precursor protein cleavage by a membrane-bound protease
52/100 ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America
Key finding: Previous studies have established that amyloid precursor proteins are secreted after proteolytic cleavage within the beta-amyloid peptide. +2 more findings
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1992-07-01
Olfactory bulb lesions in Alzheimer's disease
36/100 ✓ Peer-reviewed Brain scans and imaging Neurobiology of aging
Key finding: In some cases, with less severe neocortical pathology, the terminal arborizations of olfactory nerve appear hyperplastic and are associated with focal accumulations of A-4 (beta-amyloid) immunoreactivity that are not detectable by standard amyloid stains.
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June 1992 5
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1992-06-01
Solution conformations and aggregational properties of synthetic amyloid beta-peptides of Alzheimer's disease. Analysis of circular dichroism spectra
36/100 ✓ Peer-reviewed Vascular contributions Journal of molecular biology
Key finding: Peptide concentration studies showed that the beta-sheet conformation is oligomeric (intermolecular), whereas the alpha-helical conformation is monomeric (intramolecular). +2 more findings
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1992-06-01
Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments
41/100 ✓ Peer-reviewed Risk genes beyond APOE Nature
Key finding: Incubation of living human endothelial cells with a beta APP antibody revealed reinternalization of mature beta APP from the cell surface and its targeting to endosomes/lysosomes. +2 more findings
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1992-06-01
Dementia after stroke: baseline frequency, risks, and clinical features in a hospitalized cohort
55/100 ✓ Peer-reviewed Vascular contributions Neurology
Key finding: Using modified DSM-III-R criteria, we found dementia in 66 patients (26.3%). +4 more findings
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1992-06-01
Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene
58/100 ✓ Peer-reviewed Brain tissue and pathology Nature genetics
Key finding: We now report, a novel base mutation in the same exon of the APP gene which co-segregates in one family with presenile dementia and cerebral haemorrhage due to cerebral amyloid angiopathy. +2 more findings
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1992-06-01
Black and white dementia caregivers: a comparison of their adaptation, adjustment, and service utilization
41/100 ✓ Peer-reviewed Disparities The Gerontologist
Key finding: We compared black (n = 33) and white (n = 119) caregivers of dementia patients on indices of adaptation, adjustment, and utilization of supportive services. +2 more findings
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May 1992 6
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1992-05-01
Detection and Staging of Dementia in Alzheimer's Disease
43/100 ✓ Peer-reviewed Risk factors Archives of Neurology
Key finding: Our earlier studies using the Consortium to Establish a Registry of Alzheimer's Disease neuropsychological battery showed that delayed recall was a highly sensitive indicator of early Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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1992-05-01
Mitochondrial genetics: a paradigm for aging and degenerative diseases?
41/100 ✓ Peer-reviewed Risk factors Science (New York, N.Y.)
Key finding: Studies of diseases caused by mitochondrial DNA mutations suggest that a variety of degenerative processes may be associated with defects in oxidative phosphorylation (OXPHOS).
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1992-05-01
Testing for limits of cognitive reserve capacity: a promising strategy for early diagnosis of dementia?
62/100 ✓ Peer-reviewed Prevention trials Journal of gerontology
Key finding: Stepwise regression analyses demonstrated that only healthy elderly profited from training and that only post-training scores predicted the psychiatric "at risk" diagnosis. +1 more finding
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1992-05-01
Cognitive impairments in Parkinson's disease
39/100 ✓ Peer-reviewed Digital health tools Neurologic clinics
Key finding: Whitehouse suggested that a prospective study of several different dementias studied in parallel, examining a wide range of cognitive skills, is required before the cortical/subcortical classification scheme can be validated.
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1992-05-01
Diagnosis of dementia in a heterogeneous population. Development of a neuropsychological paradigm-based diagnosis of dementia and quantified correction for the effects of education
52/100 ✓ Peer-reviewed Getting a diagnosis Archives of neurology
Key finding: Eighteen percent of those with 8 or less years of education met criteria for dementia compared with 5% of those with more than 8 years of education. +2 more findings
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1992-05-01
Milacemide: a placebo-controlled study in senile dementia of the Alzheimer type
60/100 ✓ Peer-reviewed Treatments Journal of the American Geriatrics Society
Key finding: Milacemide does not appear to be an effective treatment in enhancing cognition in SDAT patients. +1 more finding
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April 1992 2
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1992-04-10
Alzheimer's Disease: The Amyloid Cascade Hypothesis
61/100 ✓ Peer-reviewed Disease mechanisms Science
Full summary, score breakdown and related studies → Original source
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1992-04-01
Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein
50/100 ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America
Key finding: Secreted forms of APP found in blood plasma and cerebrospinal fluid arise by proteolytic cleavage of APP within the beta/A4 amyloid domain, precluding the possibility of amyloidogenesis for that population of molecules. +3 more findings
Full summary, score breakdown and related studies → Original source
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