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Home › Research › Brain scans and imaging

Tau-PET imaging with [18F]AV-1451 in primary progressive apraxia of speech

Rene L Utianski, Jennifer L Whitwell, Christopher G Schwarz, Matthew L Senjem, Nirubol Tosakulwong, Joseph R Duffy, Heather M Clark, Mary M Machulda et al.. Cortex; a journal devoted to the study of the nervous system and behavior, 2018-01-02

This page is alzhub.org's plain-English summary of a published study, not the paper itself. It is generated from the record we hold for this study, sourced and linked below — check the original for the full text and methods.

✓ Peer-reviewed alzhub usefulness score 54 out of 100. Brain scans and imaging

Topic: Plasma and spinal-fluid biomarkers

Apraxia of speech is a motor speech disorder characterized by combinations of slow speaking rate, abnormal prosody, distorted sound substitutions, and trial-and-error articulatory movements. Apraxia of speech is due to abnormal planning and/or programming of speech production. It is referred to as primary progressive apraxia of speech (PPAOS) when it is the only symptom of a neurodegenerative condition. Past reports suggest an association of PPAOS with primary 4-repeat (4R) tau (e.g., progressive supranuclear palsy, corticobasal degeneration), rather than amyloid, pathology. The goal of the current study was to investigate the distribution of tau tracer uptake using [18F]AV-1451 positron emission tomography (PET) imaging in patients with PPAOS. Fourteen PPAOS patients underwent [18F]AV-1451 PET (tau-PET) imaging, [C11] Pittsburgh Compound B (PiB) PET and structural MRI and were matched 3:1 by age and sex to 42 cognitively normal controls. Tau-PET uptake was assessed at the region-of-interest (ROI) level and at the voxel-level. The PPAOS group (n = 14) showed increased tau-PET uptake in the precentral gyrus, supplementary motor area and Broca's area compared to controls. To examine whether tau deposition in Broca's area was related to the presence of aphasia, we examined a subgroup of the PPAOS patients who had predominant apraxia of speech, with concomitant aphasia (PPAOSa; n = 7). The PPAOSa patients showed tau-PET uptake in the same regions as the whole group. However, the remaining seven patients who did not have aphasia showed uptake only in superior premotor and precentral cortices, with no uptake observed in Broca's area. This cross-sectional study demonstrates that elevated tau tracer uptake is observed using [18F]AV-1451 in PPAOS. Further, it appears that [18F]AV-1451 is sensitive to the regional distribution of tau deposition in different stages of PPAOS, given the relationship between tau signal in Broca's area and the presence of aphasia.

Key findings

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Study details

How this study scored 54/100
How this study's score is builtJournal tier 7 of 10; Journal's citation record left out, no data; Study design 4 of 12; Strength of evidence 1 of 5; Peer-review validation 10 of 10; How recent 2 of 5; Sample size 1 of 4; Effect reported 0 of 3; Studied in people 3 of 3; Randomised / blinded 0 of 2; Times cited left out, no data; Citations per year left out, no data; Impact for its field and year left out, no data; Cited by studies here left out, no data; Still being cited left out, no data; Senior author's track record left out, no data; Institution's track record left out, no data; Multi-centre collaboration left out, no data; Indexed in PubMed 2 of 2; Free to read left out, no data. 30 of the 56 points it could be judged on, which is 54 of 100. Total 54 of 100.30 of the 56 points we could judge = 54 of 100

Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 30 of the 56 points we could judge it on, which is 54 out of 100.

ComponentPointsWhy
Journal tier 7 / 10 Tier 3 — peer-reviewed journal (Cortex; a journal devoted to the study of the nervous system and behavior)
Journal's citation record — / 4 No journal record from OpenAlex — left out of this score
Study design 4 / 12 A snapshot of people at one point in time
Strength of evidence 1 / 5 Rated “low” in our summary
Peer-review validation 10 / 10 Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent 2 / 5 2018 — within 10 year(s) of the newest study here
Sample size 1 / 4 14 participants
Effect reported 0 / 3 No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people 3 / 3 Studied in people (participant count stated)
Randomised / blinded 0 / 2 No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited — / 7 No citation count (not found in OpenAlex) — left out of this score
Citations per year — / 5 No citation count or no year — left out of this score
Impact for its field and year — / 6 No field-weighted citation impact (OpenAlex has none yet) — left out of this score
Cited by studies here — / 6 Not yet checked against this library's citation graph — left out of this score
Still being cited — / 4 No yearly citation counts — left out of this score
Senior author's track record — / 4 Senior author's record not available — left out of this score
Institution's track record — / 3 No institution listed in OpenAlex — left out of this score
Multi-centre collaboration — / 3 Institutions not listed — left out of this score
Indexed in PubMed 2 / 2 Indexed in PubMed (PMID 29353121)
Free to read — / 2 Access not recorded — left out of this score
Points 30 / 56 Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 30 of the 56 points we could judge it on is 54 out of 100.
Total 54 / 100 —

What each of these 20 components measures, and what this score is not →

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Cite this study APA, Vancouver, BibTeX · download .bib or .ris

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APA 7th

Utianski, R. L., Whitwell, J. L., Schwarz, C. G., Senjem, M. L., Tosakulwong, N., Duffy, J. R., et al. (2018). Tau-PET imaging with [18F]AV-1451 in primary progressive apraxia of speech. Cortex; a journal devoted to the study of the nervous system and behavior. https://doi.org/10.1016/j.cortex.2017.12.021

Vancouver

Utianski RL, Whitwell JL, Schwarz CG, Senjem ML, Tosakulwong N, Duffy JR, et al. Tau-PET imaging with [18F]AV-1451 in primary progressive apraxia of speech. Cortex; a journal devoted to the study of the nervous system and behavior. 2018. doi:10.1016/j.cortex.2017.12.021. PMID: 29353121.

BibTeX

@article{utianski2018-29353121,
  author  = {Utianski, Rene L and Whitwell, Jennifer L and Schwarz, Christopher G and Senjem, Matthew L and Tosakulwong, Nirubol and Duffy, Joseph R and Clark, Heather M and Machulda, Mary M and others},
  title   = {{Tau-PET imaging with [18F]AV-1451 in primary progressive apraxia of speech}},
  journal = {Cortex; a journal devoted to the study of the nervous system and behavior},
  year    = {2018},
  doi     = {10.1016/j.cortex.2017.12.021},
  pmid    = {29353121},
  url     = {https://doi.org/10.1016/j.cortex.2017.12.021}
}

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