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Decreased hemodynamic response in inferior frontotemporal regions in elderly with mild cognitive impairment
Katzorke A, Zeller JBM, Müller LD, Lauer M, Polak T, Deckert J, Herrmann MJ.. Psychiatry research. Neuroimaging, 2018-02-11
Topic: Risk, prevention and care in population studies
The verbal fluency task (VFT) is a well-established cognitive marker for mild cognitive impairment (MCI) in the prodromal stage of Alzheimer´s dementia (AD). The behavioral VFT performance of patients allows the prediction of dementia two years later. But effective compensatory mechanism might cover or reduce the predictive value of the VFT. Therefore the aim of this study is to measure the hemodynamic response during VFT in patients with mild cognitive impairment (MCI) to establish the hemodynamic response during the VFT as a screening instrument for the prediction of dementia. One method which allows measuring the hemodynamic response during speech production without severe problems with moving artifacts like in functional magnetic resonance imaging (fMRI) is the functional near-infrared spectroscopy (fNIRS). It is optimal as a screening instrument, as it is easy to apply and without any contraindications. In this study we assessed the hemodynamic response in prefrontal and temporal regions in patients with MCI as well as matched healthy controls with fNIRS. We found a decreased hemodynamic response in the inferior frontotemporal cortex for the MCI group. Our results indicate that a frontotemporal decreased hemodynamic response could serve as a diagnostic biomarker for dementia.
Key findings
- We found a decreased hemodynamic response in the inferior frontotemporal cortex for the MCI group.
- Our results indicate that a frontotemporal decreased hemodynamic response could serve as a diagnostic biomarker for dementia.
Why it matters
This study found a decreased hemodynamic response in the inferior frontotemporal cortex during a verbal fluency task in people with mild cognitive impairment, suggesting it could serve as a diagnostic biomarker. It is about diagnosis and does not report any treatment, cure, or prevention.
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Study details
- Evidence strengthLow
How this study scored 40/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Psychiatry research. Neuroimaging) |
| Journal's citation record | 1 / 4 | Psychiatry Research Neuroimaging: journal h-index 145 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 56 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 5.6 citations a year over 10 year(s) since 2018 |
| Impact for its field and year | 3 / 6 | Cited 3.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 2 / 4 | Cited 21 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Martin J. Herrmann: h-index 60 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Würzburg: institution h-index 852 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 29472145) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 40 / 100 | — |
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Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Katzorke, A., Zeller, J. B. M., Müller, L. D., Lauer, M., Polak, T., Deckert, J., et al. (2018). Decreased hemodynamic response in inferior frontotemporal regions in elderly with mild cognitive impairment. Psychiatry research. Neuroimaging. https://doi.org/10.1016/j.pscychresns.2018.02.003
Vancouver
Katzorke A, Zeller JBM, Müller LD, Lauer M, Polak T, Deckert J, et al. Decreased hemodynamic response in inferior frontotemporal regions in elderly with mild cognitive impairment. Psychiatry research. Neuroimaging. 2018. doi:10.1016/j.pscychresns.2018.02.003. PMID: 29472145.
BibTeX
@article{katzorke2018-29472145,
author = {Katzorke, A. and Zeller, J. B. M. and Müller, L. D. and Lauer, M. and Polak, T. and Deckert, J. and Herrmann, M. J.},
title = {{Decreased hemodynamic response in inferior frontotemporal regions in elderly with mild cognitive impairment}},
journal = {Psychiatry research. Neuroimaging},
year = {2018},
doi = {10.1016/j.pscychresns.2018.02.003},
pmid = {29472145},
url = {https://doi.org/10.1016/j.pscychresns.2018.02.003}
}
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