An Inflammation-Centric View of… | 2018

This page is alzhub.org's plain-English summary of a published study, not the paper itself. It is generated from the record we hold for this study, sourced and linked below — check the original for the full text and methods.

48/100

✓ Peer-reviewed alzhub usefulness score 48 out of 100. Inflammation and the immune system

Topic: Brain proteins, microglia and lab models

Plain-language summary

Inflammation is a complex biological response fundamental to how the body deals with injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a normally beneficial acute inflammatory response, chronic inflammation can lead to tissue damage and ultimately its destruction, and often results from an inappropriate immune response. Inflammation in the nervous system ("neuroinflammation"), especially when prolonged, can be particularly injurious.

What this study adds

Evidence grade: Low

This is a narrative review. This review states that chronic inflammation in the nervous system can be particularly injurious and contributes importantly to disease processes, including in Alzheimer's disease. It offers no treatment or prevention result, only the general idea that prolonged neuroinflammation is harmful.

Taken from this record’s own fields, not from reading the paper. The grade is assigned from the abstract’s wording; what that means.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Skaper, S. D., Facci, L., Zusso, M., & Giusti, P. (2018). An Inflammation-Centric View of Neurological Disease: Beyond the Neuron. Frontiers in cellular neuroscience. https://doi.org/10.3389/fncel.2018.00072

Vancouver

Skaper SD, Facci L, Zusso M, Giusti P. An Inflammation-Centric View of Neurological Disease: Beyond the Neuron. Frontiers in cellular neuroscience. 2018. doi:10.3389/fncel.2018.00072. PMID: 29618972.

BibTeX

@article{skaper2018-29618972,
  author  = {Skaper, S. D. and Facci, L. and Zusso, M. and Giusti, P.},
  title   = {{An Inflammation-Centric View of Neurological Disease: Beyond the Neuron}},
  journal = {Frontiers in cellular neuroscience},
  year    = {2018},
  doi     = {10.3389/fncel.2018.00072},
  pmid    = {29618972},
  url     = {https://doi.org/10.3389/fncel.2018.00072}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.

How to read this study

Design: this is a narrative review. It summarises a field without a fixed search method, so it shows how authors read the evidence rather than measuring it. Use it to find the primary studies, not as a result in itself.
Size: the record gives no participant count. Look for one in the original before trusting a pattern.
Effect: the record gives no effect size, so the summary above cannot say how large any difference was.

What the evidence grade means here

This page is graded low. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. Low means the abstract matched neither pattern. It is the default label, and it does not mean the work is poor; many sound lab and imaging papers land here. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

New to reading papers? Six questions to ask of any Alzheimer’s study · how we score.

Key findings

Unlike a normally beneficial acute inflammatory response, chronic inflammation can lead to tissue damage and ultimately its destruction, and often results from an inappropriate immune response.
Inflammation in the nervous system ("neuroinflammation"), especially when prolonged, can be particularly injurious.
While inflammation per se may not cause disease, it contributes importantly to disease pathogenesis across both the peripheral (neuropathic pain, fibromyalgia) and central [e.g., Alzheimer disease, Parkinson disease, multiple sclerosis, motor neuron disease, ischemia and traumatic brain injury, depression, and autism spectrum disorder] nervous systems.
The existence of extensive lines of communication between the nervous system and immune system represents a fundamental principle underlying neuroinflammation.

Why it matters

This review states that chronic inflammation in the nervous system can be particularly injurious and contributes importantly to disease processes, including in Alzheimer's disease. It offers no treatment or prevention result, only the general idea that prolonged neuroinflammation is harmful.

Study details

Evidence strengthLow

How this study scored 48/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Frontiers in cellular neuroscience)
Journal's citation record	2 / 4	Frontiers in Cellular Neuroscience: journal h-index 175 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2018 — within 10 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	6 / 7	Cited 457 times (OpenAlex, 2026-10-10)
Citations per year	4 / 5	45.7 citations a year over 10 year(s) since 2018
Impact for its field and year	5 / 6	Cited 20.8× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	1 / 6	Cited by 1 other studies in this library
Still being cited	3 / 4	Cited 113 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Pietro Giusti: h-index 41 (OpenAlex, whole career)
Institution's track record	1 / 3	University of Padua: institution h-index 1,158 (OpenAlex)
Multicenter collaboration	0 / 3	OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete)
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 29618972)
Free to read	2 / 2	Free to read
Total	48 / 100	—

What each of these 20 components measures, and what this score is not →

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