Multimodal and Multiscale Deep Neural Networks for the Early Diagnosis of Alzheimer's Disease using structural MR and FDG-PET images

Topic: Brain imaging, connectivity and assessment

Alzheimer's Disease (AD) is a progressive neurodegenerative disease where biomarkers for disease based on pathophysiology may be able to provide objective measures for disease diagnosis and staging. Neuroimaging scans acquired from MRI and metabolism images obtained by FDG-PET provide in-vivo measurements of structure and function (glucose metabolism) in a living brain. It is hypothesized that combining multiple different image modalities providing complementary information could help improve early diagnosis of AD. In this paper, we propose a novel deep-learning-based framework to discriminate individuals with AD utilizing a multimodal and multiscale deep neural network. Our method delivers 82.4% accuracy in identifying the individuals with mild cognitive impairment (MCI) who will convert to AD at 3 years prior to conversion (86.4% combined accuracy for conversion within 1-3 years), a 94.23% sensitivity in classifying individuals with clinical diagnosis of probable AD, and a 86.3% specificity in classifying non-demented controls improving upon results in published literature.

Key findings

• Our method delivers 82.4% accuracy in identifying the individuals with mild cognitive impairment (MCI) who will convert to AD at 3 years prior to conversion (86.4% combined accuracy for conversion within 1-3 years), a 94.23% sensitivity in classifying individuals with clinical diagnosis of probable AD, and a 86.3% specificity in classifying non-demented controls improving upon results in published literature.

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Study details

• Effect size82.4%; 86.4%; 94.23%
• Evidence strengthLow

Read the original

• DOI: 10.1038/s41598-018-22871-z
• PubMed: 29632364
• Original source →

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@article{lu2018-29632364,
  author  = {Lu, D. and Popuri, K. and Ding, G. W. and Balachandar, R. and Beg, M. F. and {Alzheimer’s Disease Neuroimaging Initiative}},
  title   = {{Multimodal and Multiscale Deep Neural Networks for the Early Diagnosis of Alzheimer's Disease using structural MR and FDG-PET images}},
  journal = {Scientific reports},
  year    = {2018},
  doi     = {10.1038/s41598-018-22871-z},
  pmid    = {29632364},
  url     = {https://doi.org/10.1038/s41598-018-22871-z}
}

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