Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 26,576–26,600 of 27,380 studies, newest first · page 1064 of 1096.
January 1995 12
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1995-01-01
Loss of synaptophysin-like immunoreactivity in the hippocampal formation is an early phenomenon in Alzheimer's disease
36/100 ✓ Peer-reviewed Disease mechanisms Neuroscience
Key finding: The synaptophysin-like immunoreactivity was decreased in the hippocampus and the entorhinal cortex in patients with definite and possible Alzheimer's disease but not in multi-infarct dementia patients compared to controls. +2 more findings
Full summary, score breakdown and related studies → Original source
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1995-01-01
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
52/100 ✓ Peer-reviewed Laboratory science Journal of the Royal Statistical Society Series B (Statistical Methodology)
Key finding: The common approach to the multiplicity problem calls for controlling the familywise error rate (FWER). +4 more findings
Full summary, score breakdown and related studies → Original source
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1995-01-01
The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) as a screening tool for dementia for a predominantly illiterate Chinese population
46/100 ✓ Peer-reviewed Cognitive tests and assessment Neurology
Key finding: Original studies conducted in Australia showed that its score was not influenced by the subjects' educational backgrounds and that it performed at least as well as the Mini-Mental State Examination (MMSE) as a screening instrument for dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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1995-01-01
Education and change in cognitive function. The Epidemiologic Catchment Area Study
50/100 ✓ Peer-reviewed Cognitive tests and assessment Annals of epidemiology
Key finding: Cognitive function was assessed at both time points by the Mini-Mental State Examination (MMSE); cognitive decline was coded as a dichotomous variable and was defined as 1 if the subject's score had declined 3 or more points from the baseline MMSE score at the 1-year follow-up interview and as 0 otherwise. +3 more findings
Full summary, score breakdown and related studies → Original source
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1995-01-01
Volumes of hippocampus, amygdala and frontal lobes in the MRI-based diagnosis of early Alzheimer's disease: correlation with memory functions
45/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of neural transmission. Parkinson's disease and dementia section
Key finding: We examined 32 patients diagnosed according to the NINCDS-ADRDA criteria of probable AD and 16 age-matched healthy cognitively normal controls. +3 more findings
Full summary, score breakdown and related studies → Original source
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1995-01-01
Decreased phospholipase A2 activity in Alzheimer brains
42/100 ✓ Peer-reviewed Risk genes beyond APOE Biological psychiatry
Key finding: In cholinergic neurons PLA2 controls the physico-chemical properties of neuronal membranes as well as the breakdown of phosphatidylcholine to produce choline for acetylcholine synthesis. +3 more findings
Full summary, score breakdown and related studies → Original source
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1995-01-01
Cholinesterases and the pathology of Alzheimer disease
39/100 ✓ Peer-reviewed Risk genes beyond APOE Alzheimer disease and associated disorders
Key finding: Simultaneous with this loss, cholinesterase (ChE) activity emerges in AD cortex in the form of AChE and butyrylcholinesterase activity associated with plaques, tangles, and amyloid angiopathy. +3 more findings
Full summary, score breakdown and related studies → Original source
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1995-01-01
Assessment of cognitive decline associated with aging: a comparison of individuals with Down syndrome and other etiologies
32/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Research in developmental disabilities
Key finding: Analyses of variance using factor scores demonstrated articulation to be significantly poorer in the DS sample at and above 40 years.
Full summary, score breakdown and related studies → Original source
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1995-01-01
Dementia lacking distinctive histopathology: clinicopathological evaluation of 32 cases
45/100 ✓ Peer-reviewed Digital health tools Acta neuropathologica
Key finding: The retrospective evaluation of the clinical records revealed the consistent presence of "frontal" symptomatology, including loss of personal awareness, inappropriate euphoria and stereotyped behavior. +3 more findings
Full summary, score breakdown and related studies → Original source
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1995-01-01
When home caregiving ends: a longitudinal study of outcomes for caregivers of relatives with dementia
47/100 ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society
Key finding: Caregivers most frequently cite deteriorating patient conditions as the main causes of ending home care. +1 more finding
Full summary, score breakdown and related studies → Original source
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1995-01-01
Depressive disorders in primary care: prevalence, functional disability, and identification
55/100 ✓ Peer-reviewed Disparities Journal of general internal medicine
Key finding: SubD was more prevalent than MDD in these primary care settings. +2 more findings
Full summary, score breakdown and related studies → Original source
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1995-01-01
Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease
49/100 ✓ Peer-reviewed Genetics Proceedings of the National Academy of Sciences of the United States of America
Key finding: The apolipoprotein E4 (APOE4) allele is associated with an early age of onset of the nonfamilial form of Alzheimer disease (AD) and with increased beta protein amyloid deposition in the brain. +2 more findings
Full summary, score breakdown and related studies → Original source
December 1994 11
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1994-12-01
Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red
36/100 ✓ Peer-reviewed Risk factors Proceedings of the National Academy of Sciences of the United States of America
Key finding: In Alzheimer disease, beta A aggregates and accumulates in the brain as inert diffuse plaques or compact plaques associated with neurodegenerative changes. +3 more findings
Full summary, score breakdown and related studies → Original source
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1994-12-01
Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease
36/100 ✓ Peer-reviewed Genetics Trends in neurosciences
Key finding: Recent evidence indicates that apolipoprotein E (ApoE) plays a central role in the hippocampal response to injury. +2 more findings
Full summary, score breakdown and related studies → Original source
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1994-12-01
Clinical applications of magnetic resonance spectroscopy
36/100 ✓ Peer-reviewed Vascular contributions Magnetic resonance quarterly
Key finding: It provides diagnostic patterns of altered neurochemistry. +4 more findings
Full summary, score breakdown and related studies → Original source
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1994-12-01
[Neuropsychological tests of simple application for diagnosing dementia]
39/100 ✓ Peer-reviewed Cognitive tests and assessment Arquivos de neuro-psiquiatria
Key finding: The scores in the neuropsychological tests were compared to those obtained by thirty normal volunteers paired for age, sex and education. +3 more findings
Full summary, score breakdown and related studies → Original source
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1994-12-01
Corticonigral degeneration with neuronal achromasia presenting with primary progressive aphasia: ultrastructural and immunocytochemical studies
40/100 ✓ Peer-reviewed Drug development Journal of the neurological sciences
Key finding: Postmortem examination revealed severe focal atrophy of the cerebral convolutions in the frontal operculum, superior frontal gyrus, and superior and transverse temporal gyri in addition to diffuse atrophy of the frontal and temporal lobes in both hemispheres. +3 more findings
Full summary, score breakdown and related studies → Original source
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1994-12-01
Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation
48/100 ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America
Key finding: In studies of cell lines transfected with beta-amyloid precursor protein (beta APP) cDNAs, the beta APP mutation K670N/M671L found in a Swedish familial AD (FAD) pedigree has previously been shown to cause a marked augmentation of A beta secretion. +3 more findings
Full summary, score breakdown and related studies → Original source
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1994-12-01
Correlates of Mini-Mental Status Examination scores among elderly demented patients: the influence of race-ethnicity
45/100 ✓ Peer-reviewed Disparities Journal of clinical epidemiology
Key finding: Data on 1888 patients seen at Alzheimer's Disease Diagnostic and Treatment Centers in California were used to examine possible differences in Mini-Mental State Examination (MMSE) results for different racial-ethnic groups. +1 more finding
Full summary, score breakdown and related studies → Original source
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1994-12-01
Characteristics of nonresponders in a community survey of the elderly
46/100 ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society
Key finding: Nonresponders in community surveys of the elderly appear to be disproportionately cognitively impaired. +2 more findings
Full summary, score breakdown and related studies → Original source
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1994-12-01
The Clinician Interview-Based Impression (CIBI): a clinician's global change rating scale in Alzheimer's disease
65/100 ✓ Peer-reviewed Caregiving Neurology
Key finding: The CIBI ratings were weakly but significantly correlated, in the expected direction, with change scores on the quantitative cognitive assessments. +1 more finding
Full summary, score breakdown and related studies → Original source
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1994-12-01
The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia
58/100 ✓ Peer-reviewed Caregiving Neurology
Key finding: The NPI uses a screening strategy to minimize administration time, examining and scoring only those behavioral domains with positive responses to screening questions. +4 more findings
Full summary, score breakdown and related studies → Original source
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1994-12-01
Lower cognitive performance in normal older adult male twins carrying the apolipoprotein E epsilon 4 allele
46/100 ✓ Peer-reviewed Genetics Archives of neurology
Key finding: The apoE epsilon 4 allele may be associated with decreased cognitive function in discordant twin pairs. +4 more findings
Full summary, score breakdown and related studies → Original source
November 1994 2
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1994-11-01
Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease
40/100 ✓ Peer-reviewed Disease mechanisms Annals of neurology
Key finding: We examined whether Alzheimer's disease (AD) is associated with increased oxidative damage to nDNA and mtDNA in postmortem brain tissue. +3 more findings
Full summary, score breakdown and related studies → Original source
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1994-11-01
Preliminary NINDS neuropathologic criteria for Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy)
40/100 ✓ Peer-reviewed Inflammation and the immune system Neurology
Key finding: A high density of neurofibrillary tangles and neuropil threads in the basal ganglia and brain-stem is crucial for the diagnosis of typical PSP. +4 more findings
Full summary, score breakdown and related studies → Original source
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