Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 26,351–26,375 of 27,380 studies, newest first · page 1055 of 1096.
July 1996 2
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1996-07-01
Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease
61/100 ✓ Peer-reviewed Getting a diagnosis The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: Decreases in individual lamina were even more dramatic, with the number of neurons in layer II decreasing by 60% and in layer IV by 40% compared with controls. +3 more findings
Full summary, score breakdown and related studies → Original source
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1996-07-01
[Effectiveness of brief infusions with Ginkgo biloba Special Extract EGb 761 in dementia of the vascular and Alzheimer type]
55/100 ✓ Peer-reviewed Treatments Zeitschrift fur Gerontologie und Geriatrie
Key finding: After therapy, patients of the active substance group scored significantly better (p < 0.05) on each outcome measure than those who received placebo. +1 more finding
Full summary, score breakdown and related studies → Original source
June 1996 9
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1996-06-01
Tumor necrosis factor alpha inhibits glutamate uptake by primary human astrocytes. Implications for pathogenesis of HIV-1 dementia
47/100 ✓ Peer-reviewed Inflammation and the immune system The Journal of biological chemistry
Key finding: To test this hypothesis, we examined the effect of the pro-inflammatory cytokine, tumor necrosis factor alpha (TNFalpha), produced by HIV-1-infected macrophages and microglia, on glutamate transport by primary human fetal astrocytes (PHFAs). +3 more findings
Full summary, score breakdown and related studies → Original source
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1996-06-01
Cellular reservoirs of HIV-1 in the central nervous system of infected individuals: identification by the combination of in situ polymerase chain reaction and immunohistochemistry
49/100 ✓ Peer-reviewed Inflammation and the immune system AIDS (London, England)
Key finding: The majority of HIV-1-infected individuals manifest a plethora of central nervous system (CNS) diseases unrelated to opportunistic infections, including AIDS dementia complex, encephalitis, and various other disorders of the CNS. +3 more findings
Full summary, score breakdown and related studies → Original source
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1996-06-01
Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: the CERAD experience, Part XV
55/100 ✓ Peer-reviewed Brain tissue and pathology Neurology
Key finding: Eighty-three percent showed at least a mild degree of amyloid angiopathy. +3 more findings
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1996-06-01
Dementia and Down syndrome
29/100 ✓ Peer-reviewed Down syndrome and Alzheimer's The Journal of family practice
Key finding: Through deinstitutionalization, more adults with mental retardation are living in the community under the care of family physicians. +2 more findings
Full summary, score breakdown and related studies → Original source
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1996-06-01
Prevalence of dementia in an elderly rural population: effects of age, sex, and education
42/100 ✓ Peer-reviewed Disparities Journal of neurology, neurosurgery, and psychiatry
Key finding: In both Alzheimer and vascular dementia subtypes, the prevalence rates did not differ between men and women, but increased with age and were higher in subjects with a low level of education. +1 more finding
Full summary, score breakdown and related studies → Original source
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1996-06-01
An epidemiological study of dementia in a rural community in Kerala, India
46/100 ✓ Peer-reviewed Disparities The British journal of psychiatry : the journal of mental science
Key finding: Dementia is an important cause of morbidity in the geriatric population in this community, where families take responsibility for the care of relatives with dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
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1996-06-01
Localization of HIV-1 in human brain using polymerase chain reaction/in situ hybridization and immunocytochemistry
47/100 ✓ Peer-reviewed Disparities Annals of neurology
Key finding: Human immunodeficiency virus type 1 (HIV-1) infects the brains of a majority of patients with the acquired immunodeficiency syndrome (AIDS), and has been linked to the development of a progressive dementia termed "HIV-associated dementia." +3 more findings
Full summary, score breakdown and related studies → Original source
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1996-06-01
Natural history of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome) and clinical predictors of survival: a clinicopathological study
51/100 ✓ Peer-reviewed Getting a diagnosis Journal of neurology, neurosurgery, and psychiatry
Key finding: Onset of falls during the first year are emphasised, as they could lead to an early diagnosis and influence the prognosis of patients with PSP. +1 more finding
Full summary, score breakdown and related studies → Original source
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1996-06-01
Expression of apolipoprotein E mRNA in rat microglia
39/100 ✓ Peer-reviewed Genetics Neuroscience letters
Key finding: Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis revealed expression of apoE mRNA in cultured rat microglia. +2 more findings
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May 1996 11
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1996-05-01
Balance and strength training in older adults: intervention gains and Tai Chi maintenance
74/100 ✓ Peer-reviewed Digital health tools Journal of the American Geriatrics Society
Key finding: Randomized control intervention. +1 more finding
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1996-05-01
A femtomolar-acting neuroprotective peptide
36/100 ✓ Peer-reviewed Disease mechanisms The Journal of clinical investigation
Key finding: A novel 14-amino acid peptide, with stress-protein-like sequences, exhibiting neuroprotection at unprecedented concentrations, is revealed. +2 more findings
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1996-05-01
Risk factors for Creutzfeldt-Jakob disease: a reanalysis of case-control studies
62/100 ✓ Peer-reviewed Risk factors Neurology
Key finding: The risk of CJD was statistically significantly increased for subjects with a family history of CJD (odds ratio = 19.1; 95% CI 1.1 to 348.0). +3 more findings
Full summary, score breakdown and related studies → Original source
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1996-05-01
Neurofibrillary tangles of Alzheimer's disease brains contain 14-3-3 proteins
36/100 ✓ Peer-reviewed Drug development Neuroscience letters
Key finding: The localisation of 14-3-3 proteins compared to that of tau and ubiquitin-protein conjugates in sections of hippocampus from Alzheimer's disease (AD) brains was examined by immunohistochemistry. +1 more finding
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1996-05-01
Retinal pathology in Alzheimer's disease. I. Ganglion cell loss in foveal/parafoveal retina
36/100 ✓ Peer-reviewed Brain scans and imaging Neurobiology of aging
Key finding: Morphometric analysis of the numbers of neurons in the ganglion cell layer (GCL) of the central retina (fovea/foveola/parafoveal retina) in eyes from 9 Alzheimer's disease (AD) and 11 age-matched control cases revealed an overall decrease of 25% in total numbers of neurons in AD as compared with control eyes. +3 more findings
Full summary, score breakdown and related studies → Original source
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1996-05-01
Retinal pathology in Alzheimer's disease. II. Regional neuron loss and glial changes in GCL
40/100 ✓ Peer-reviewed Biomarkers Neurobiology of aging
Key finding: Detailed analyses of neuronal and astrocyte cell numbers in the ganglion cell layer (GCL) of whole-mounted peripheral retinas from 16 Alzheimer's disease (AD) and 11 control eyes (11 and 9 cases, respectively) demonstrate extensive neuronal loss throughout the entire retina in AD as compared to control eyes. +4 more findings
Full summary, score breakdown and related studies → Original source
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1996-05-01
Cortical synaptic changes and gliosis in normal aging, Alzheimer's disease and frontal lobe degeneration
36/100 ✓ Peer-reviewed Disease mechanisms Dementia (Basel, Switzerland)
Key finding: Against the background of normal aging, AD was compared with another degenerative disorder, frontal lobe degeneration of non-Alzheimer type (FLD). +2 more findings
Full summary, score breakdown and related studies → Original source
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1996-05-01
Differential susceptibility to neurofibrillary pathology among patients with Down syndrome
36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Dementia (Basel, Switzerland)
Key finding: The severely affected group of 5 subject (21%) had an average 54.6/mm2 of neurons and 13.9/mm/ plaques with neurofibrillary changes, whereas the moderately affected group (6 subjects; 25%) showed a significantly lower numerical density of neurons and plaques with neurofibrillary changes (25.7/mm2 and 8.1/mm2, respectively) as compared with the most affected group. +1 more finding
Full summary, score breakdown and related studies → Original source
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1996-05-01
Fluorescent light-induced chromatid breaks distinguish Alzheimer disease cells from normal cells in tissue culture
36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Proceedings of the National Academy of Sciences of the United States of America
Key finding: At least 28 of 31 normal donors and 10 of 11 donors with nonamyloid neurodegenerations gave normal test results.
Full summary, score breakdown and related studies → Original source
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1996-05-01
Effects of exercise on neurobehavioral function in community-dwelling older people more than 75 years of age
59/100 ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society
Key finding: This study demonstrates the acceptability and effectiveness of exercise on neurobehavioral function, even in older people more than 75 years of age.
Full summary, score breakdown and related studies → Original source
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1996-05-01
Induction of apolipoprotein E mRNA in the hippocampus of the gerbil after transient global ischemia
32/100 ✓ Peer-reviewed Biomarkers Brain research. Molecular brain research
Key finding: Recently, apolipoprotein E (APO-E) has also been shown to be associated with Alzheimer's disease pathology because it is localized to plaques and tangles, and the gene encoding one of the isoforms of APO-E (E4) is associated with late-onset familial and sporadic AD. +2 more findings
Full summary, score breakdown and related studies → Original source
April 1996 3
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1996-04-01
The impact of market and organizational characteristics on nursing care facility service innovation: a resource dependency perspective
40/100 ✓ Peer-reviewed Costs and economics Europe PMC (PubMed Central)
Key finding: Finally, organizational characteristics (e.g., size and proprietary status) appear to be important enabling factors influencing the propensity to provide specialty care in dedicated units. +4 more findings
Full summary, score breakdown and related studies → Original source
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1996-04-01
Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme
36/100 ✓ Peer-reviewed Disease mechanisms Neuron
Key finding: Furthermore, AChE is a potent amyloid-promoting factor when compared with other A beta-associated proteins.
Full summary, score breakdown and related studies → Original source
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1996-04-01
Characterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against tau protein
36/100 ✓ Peer-reviewed Drug development FEBS letters
Key finding: It strongly labels paired helical filament (PHF) tau from Alzheimer's disease brain in a phosphorylation-dependent manner. +4 more findings
Full summary, score breakdown and related studies → Original source
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