Home › Research › Risk factors
Aging and Alzheimer's disease: Comparison and associations from molecular to system level
Xia X, Jiang Q, McDermott J, Han JJ.. Aging cell, 2018-07-02
Topic: Amyloid, tau and blood-test diagnosis
Alzheimer's disease is the most prevalent cause of dementia, which is defined by the combined presence of amyloid and tau, but researchers are gradually moving away from the simple assumption of linear causality proposed by the original amyloid hypothesis. Aging is the main risk factor for Alzheimer's disease that cannot be explained by amyloid hypothesis. To evaluate how aging and Alzheimer's disease are intrinsically interwoven with each other, we review and summarize evidence from molecular, cellular, and system level. In particular, we focus on study designs, treatments, or interventions in Alzheimer's disease that could also be insightful in aging and vice versa.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Xia, X., Jiang, Q., McDermott, J., & Han, J. J. (2018). Aging and Alzheimer's disease: Comparison and associations from molecular to system level. Aging cell. https://doi.org/10.1111/acel.12802
Vancouver
Xia X, Jiang Q, McDermott J, Han JJ. Aging and Alzheimer's disease: Comparison and associations from molecular to system level. Aging cell. 2018. doi:10.1111/acel.12802. PMID: 29963744.
BibTeX
@article{xia2018-29963744,
author = {Xia, X. and Jiang, Q. and McDermott, J. and Han, J. J.},
title = {{Aging and Alzheimer's disease: Comparison and associations from molecular to system level}},
journal = {Aging cell},
year = {2018},
doi = {10.1111/acel.12802},
pmid = {29963744},
url = {https://doi.org/10.1111/acel.12802}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Alzheimer's disease is the most prevalent cause of dementia, which is defined by the combined presence of amyloid and tau, but researchers are gradually moving away from the simple assumption of linear causality proposed by the original amyloid hypothesis.
- Aging is the main risk factor for Alzheimer's disease that cannot be explained by amyloid hypothesis.
- To evaluate how aging and Alzheimer's disease are intrinsically interwoven with each other, we review and summarize evidence from molecular, cellular, and system level.
- In particular, we focus on study designs, treatments, or interventions in Alzheimer's disease that could also be insightful in aging and vice versa.
Why it matters
This review discusses how aging and Alzheimer's disease are interwoven at molecular, cellular, and system levels, and notes that researchers are moving away from the simple idea that amyloid alone causes the disease. It is a summary of evidence and ideas, not a report of a treatment or cure.
New to this subject? Start with our plain-English guide: Risk factors, ranked →
Study details
- Evidence strengthLow
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Aging cell) |
| Journal's citation record | 2 / 4 | Aging Cell: journal h-index 216 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 299 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 29.9 citations a year over 10 year(s) since 2018 |
| Impact for its field and year | 4 / 6 | Cited 11.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 8 other studies in this library |
| Still being cited | 3 / 4 | Cited 121 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Jing‐Dong J. Han: h-index 59 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Chinese Academy of Sciences: institution h-index 928 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 29963744) |
| Free to read | 2 / 2 | Free to read |
| Total | 50 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here. Showing 12 of 36.
Later studies that cite this one
8 studies in the alzhub library list this one in their references.
Related studies in Risk factors
Also in Risk factors
356 studies in the library are filed under Risk factors with no topic tag they share with another; these are this study's neighbours in a fixed tour of them. The Risk factors hub.