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Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated
Robinson JL, Lee EB, Xie SX, Rennert L, Suh E, Bredenberg C, Caswell C, Van Deerlin VM et al.. Brain : a journal of neurology, 2018-07-01
Topic: Brain proteins, microglia and lab models
In amyotrophic lateral sclerosis and neocortical Lewy body disease, co-pathologies associated with APOE ɛ4. These findings have implications for clinical trials that focus on monotherapies targeting tau, amyloid-β, α-synuclein and TDP-43.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Robinson, J. L., Lee, E. B., Xie, S. X., Rennert, L., Suh, E., Bredenberg, C., et al. (2018). Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated. Brain : a journal of neurology. https://doi.org/10.1093/brain/awy146
Vancouver
Robinson JL, Lee EB, Xie SX, Rennert L, Suh E, Bredenberg C, et al. Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated. Brain : a journal of neurology. 2018. doi:10.1093/brain/awy146. PMID: 29878075.
BibTeX
@article{robinson2018-29878075,
author = {Robinson, J. L. and Lee, E. B. and Xie, S. X. and Rennert, L. and Suh, E. and Bredenberg, C. and Caswell, C. and Van Deerlin, V. M. and others},
title = {{Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated}},
journal = {Brain : a journal of neurology},
year = {2018},
doi = {10.1093/brain/awy146},
pmid = {29878075},
url = {https://doi.org/10.1093/brain/awy146}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- In amyotrophic lateral sclerosis and neocortical Lewy body disease, co-pathologies associated with APOE ɛ4.
- These findings have implications for clinical trials that focus on monotherapies targeting tau, amyloid-β, α-synuclein and TDP-43.
Why it matters
This study reports that, in neurodegenerative diseases, brains often carry more than one type of abnormal protein build-up ("concomitant proteinopathies"), that this becomes more common with age, and that it is linked to the APOE ɛ4 gene variant; the APOE ɛ4 link is stated specifically for ALS and neocortical Lewy body disease. The authors say this matters for clinical trials of single-target treatments aimed at tau, amyloid-β, α-synuclein or TDP-43. The record gives no prevalence figures or effect sizes, and an association with APOE ɛ4 does not show that the gene causes these build-ups.
Study details
- Participants247
- Evidence strengthLow
How this study scored 66/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Brain : a journal of neurology) |
| Journal's citation record | 4 / 4 | Brain: journal h-index 503 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 2 / 4 | 247 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 730 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 73.0 citations a year over 10 year(s) since 2018 |
| Impact for its field and year | 5 / 6 | Cited 35.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 4 / 6 | Cited by 55 other studies in this library |
| Still being cited | 4 / 4 | Cited 298 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author John Q. Trojanowski: h-index 255 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 7 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 29878075) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 66 / 100 | — |
What each of these 20 components measures, and what this score is not →
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