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Animal models of neurodegenerative diseases
Dawson TM, Golde TE, Lagier-Tourenne C.. Nature neuroscience, 2018-09-24
Topic: Brain proteins, microglia and lab models
Animal models of adult-onset neurodegenerative diseases have enhanced the understanding of the molecular pathogenesis of Alzheimer's disease, Parkinson's disease, frontotemporal dementia, and amyotrophic lateral sclerosis. Nevertheless, our understanding of these disorders and the development of mechanistically designed therapeutics can still benefit from more rigorous use of the models and from generation of animals that more faithfully recapitulate human disease. Here we review the current state of rodent models for Alzheimer's disease, Parkinson's disease, frontotemporal dementia, and amyotrophic lateral sclerosis. We discuss the limitations and utility of current models, issues regarding translatability, and future directions for developing animal models of these human disorders.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Dawson, T. M., Golde, T. E., & Lagier-Tourenne, C. (2018). Animal models of neurodegenerative diseases. Nature neuroscience. https://doi.org/10.1038/s41593-018-0236-8
Vancouver
Dawson TM, Golde TE, Lagier-Tourenne C. Animal models of neurodegenerative diseases. Nature neuroscience. 2018. doi:10.1038/s41593-018-0236-8. PMID: 30250265.
BibTeX
@article{dawson2018-30250265,
author = {Dawson, T. M. and Golde, T. E. and Lagier-Tourenne, C.},
title = {{Animal models of neurodegenerative diseases}},
journal = {Nature neuroscience},
year = {2018},
doi = {10.1038/s41593-018-0236-8},
pmid = {30250265},
url = {https://doi.org/10.1038/s41593-018-0236-8}
}
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Key findings
- Animal models of adult-onset neurodegenerative diseases have enhanced the understanding of the molecular pathogenesis of Alzheimer's disease, Parkinson's disease, frontotemporal dementia, and amyotrophic lateral sclerosis.
- Nevertheless, our understanding of these disorders and the development of mechanistically designed therapeutics can still benefit from more rigorous use of the models and from generation of animals that more faithfully recapitulate human disease.
- Here we review the current state of rodent models for Alzheimer's disease, Parkinson's disease, frontotemporal dementia, and amyotrophic lateral sclerosis.
- We discuss the limitations and utility of current models, issues regarding translatability, and future directions for developing animal models of these human disorders.
Why it matters
This review discusses the limitations and utility of rodent models of Alzheimer's disease and other neurodegenerative diseases and calls for models that more faithfully recapitulate human disease. It reports no treatment effect and no cure or prevention.
Study details
- Evidence strengthLow
How this study scored 57/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Nature neuroscience) |
| Journal's citation record | 4 / 4 | Nature Neuroscience: journal h-index 593 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 574 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 57.4 citations a year over 10 year(s) since 2018 |
| Impact for its field and year | 5 / 6 | Cited 29.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 7 other studies in this library |
| Still being cited | 4 / 4 | Cited 214 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Clotilde Lagier‐Tourenne: h-index 49 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 7 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 30250265) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 57 / 100 | — |
What each of these 20 components measures, and what this score is not →
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