Newest studies

Detection and mapping of abnormal brain structure with a probabilistic atlas of cortical surfaces

45/100 ✓ Peer-reviewed Brain scans and imaging Journal of computer assisted tomography

Key finding: Applications of the random fluid-based probabilistic atlas include the transfer of multisubject 3D functional, vascular, and histologic maps onto a single anatomic template, the mapping of 3D atlases onto the scans of new subjects, and the rapid detection, quantification, and mapping of local shape changes in 3D medical images in disease and during normal or abnormal growth and development.

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Behavioral treatment of depression in dementia patients: a controlled clinical trial

61/100 ✓ Peer-reviewed Getting a diagnosis The journals of gerontology. Series B, Psychological sciences and social sciences

Key finding: Two active behavioral treatments, one emphasizing patient pleasant events and one emphasizing caregiver problem solving, were compared to an equal-duration typical care condition and a wait list control. +3 more findings

• Clinical Trials
• Treatments

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Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease

59/100 ✓ Peer-reviewed Getting a diagnosis Annals of neurology

Key finding: Both results were compared to cerebral metabolic activity in 22 age-similar normal control subjects. +2 more findings

• Diagnosis

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Effect of tacrine on language, praxis, and noncognitive behavioral problems in Alzheimer disease

61/100 ✓ Peer-reviewed Treatments Archives of neurology

Key finding: Tacrine stabilizes or improves specific behavioral deficits and symptoms in AD.

• Treatments
• Clinical Trials

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Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing

48/100 ✓ Peer-reviewed Genetics JAMA

Key finding: Among the 30 boxers, 11 were found to be normal (CBI score=0), 12 showed mild deficits (CBI score=1-2), 4 were moderately impaired (CBI score=3-4), and 3 showed signs of severe impairment (CBI score > 4). +2 more findings

• Genetics
• Risk Factors

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Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

59/100 ✓ Peer-reviewed Risk genes beyond APOE Science

Parkinson's disease (PD) is a common neurodegenerative disorder with a lifetime incidence of approximately 2 percent.

• Genetics
• Other Dementias

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NF-kappa B: a crucial transcription factor for glial and neuronal cell function

36/100 ✓ Peer-reviewed Disease mechanisms Trends in neurosciences

Key finding: Apart from its role in these events, evidence has begun to accumulate that NF-kappa B is involved in brain function, particularly following injury and in neurodegenerative conditions such as Alzheimer's disease. +4 more findings

• Brain Biology

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A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease: the Baltimore Longitudinal Study of Aging

59/100 ✓ Peer-reviewed Risk factors Neurology

Key finding: Previous reports have suggested that estrogen replacement therapy (ERT) in women may exert a protective effect on their risk of developing Alzheimer's disease (AD). +3 more findings

• Risk Factors
• Treatments

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The heat shock-induced hyperphosphorylation of tau is estrogen-independent and prevented by androgens: implications for Alzheimer disease

36/100 ✓ Peer-reviewed Drug development Proceedings of the National Academy of Sciences of the United States of America

Key finding: We have shown that heat shock induces rapid dephosphorylation of tau in both female and male rats followed by hyperphosphorylation only in female rats. +1 more finding

• Prevention

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Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases

36/100 ✓ Peer-reviewed Drug development FEBS letters

Key finding: These findings double the number of candidate protein kinases for the hyperphosphorylation of tau in Alzheimer's disease and other neurodegenerative disorders.

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Fringe modulates Notch-ligand interactions

41/100 ✓ Peer-reviewed Vascular contributions Nature

Key finding: We found that Ser and Dl maintain each other's expression by a positive feedback loop. fng is expressed specifically by dorsal cells and functions to position and restrict this feedback loop to the developing dorsal-ventral boundary.

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Reliability of the Washington University Road Test. A performance-based assessment for drivers with dementia of the Alzheimer type

45/100 ✓ Peer-reviewed Clinical safety Archives of neurology

Key finding: Dementia adversely affects driving performance even in its mild stages, although some persons with DAT seem to drive safely for some time after disease onset.

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Stress effects on morphology and function of the hippocampus

36/100 ✓ Peer-reviewed Clinical safety Annals of the New York Academy of Sciences

Key finding: Studies with in vivo microdialysis in several laboratories have shown that glutamate release in the hippocampus increases in stress and that stress-induced glutamate release is reduced by adrenalectomy. +2 more findings

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Dietary antioxidants and Parkinson disease. The Rotterdam Study

48/100 ✓ Peer-reviewed Long-term cohort studies Archives of neurology

Key finding: The community-based Rotterdam Study, the Netherlands. +3 more findings

• Other Dementias
• Lifestyle

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The Clock Drawing Test for dementia of the Alzheimer's type: A comparison of three scoring methods in a memory disorders clinic

42/100 ✓ Peer-reviewed Cognitive tests and assessment International journal of geriatric psychiatry

Key finding: Retrospective analysis of clock drawing performance using three published scoring methods (Shulman, Sunderland and Wolf-Klein). +3 more findings

• Diagnosis

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Frontotemporal dementia and parkinsonism linked to chromosome 17: a consensus conference. Conference Participants

51/100 ✓ Peer-reviewed Lewy body dementia Annals of neurology

Key finding: We held an international consensus conference on frontotemporal dementia, behavioral disturbances, and parkinsonism linked to chromosome 17 to determine whether these are homogeneous or heterogeneous disorders, to agree on terminology, and to develop strategies for further research. +2 more findings

• Other Dementias
• Genetics

Full summary, score breakdown and related studies → Original source

Alzheimer-like visual deficits in Down syndrome

36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer disease and associated disorders

Key finding: Taken together, the results point to AD-like visual deficits in DS. +2 more findings

• Down Syndrome

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Prevalence and severity of cognitive impairment with and without dementia in an elderly population

63/100 ✓ Peer-reviewed How common it is Lancet (London, England)

Key finding: CIND is commonly associated with functional disability and a need for institutional care. +1 more finding

• Diagnosis

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Racial, ethnic, and cultural differences in dementia caregiving: review and analysis

57/100 ✓ Peer-reviewed Caregiving The Gerontologist

Key finding: Compared to White caregivers, non-White caregivers: a) were less likely to be a spouse and more likely to be an adult child, friend, or other family member, b) reported lower levels of caregiver stress, burden, and depression, c) endorsed more strongly held beliefs about filial support, and d) were more likely to use prayer, faith, or religion as coping mechanisms.

• Caregiving
• Health Equity

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Localization of manganese superoxide dismutase in the cerebral cortex and hippocampus of Alzheimer-type senile dementia

27/100 ✓ Peer-reviewed Biomarkers Osaka city medical journal

Key finding: This suggests that Mn-SOD scavenger system is associated with the formation of senile plaques. +1 more finding

• Brain Biology

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Volume loss of the hippocampus and temporal lobe in healthy elderly persons destined to develop dementia

40/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: NoD as well as PreD subjects had significant, time-dependent decreases in hippocampal and parahippocampal volume. +4 more findings

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A randomized, controlled trial of linopirdine in the treatment of Alzheimer's disease

75/100 ✓ Peer-reviewed Clinical trials The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

Key finding: No difference was seen in Clinical Global Impression scores between patients receiving placebo and those receiving linopirdine (n = 189). +3 more findings

• Clinical Trials
• Treatments

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4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease

36/100 ✓ Peer-reviewed Disease mechanisms Journal of neurochemistry

Key finding: Recent studies have demonstrated oxidative damage is one of the salient features of Alzheimer's disease (AD). +2 more findings

• Brain Biology

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Whipple disease. Clinical review of 52 cases. The SNFMI Research Group on Whipple Disease. Société Nationale Française de Médecine Interne

43/100 ✓ Peer-reviewed Disease mechanisms Medicine

Key finding: These results are discussed in the light of previously published series and case reports of Whipple disease. +1 more finding

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Indirect bright light improves circadian rest-activity rhythm disturbances in demented patients

43/100 ✓ Peer-reviewed Risk factors Biological psychiatry

Key finding: Actigraphy was performed before, during, and after 4 weeks of increased illumination in the living rooms of 22 patients with dementia clinically diagnosed as probable Alzheimer's disease, multi-infarct dementia, dementia associated with alcoholism, or normal pressure hydrocephalus. +1 more finding

Full summary, score breakdown and related studies → Original source