Newest studies

Promoting Brain Health in the Context of Normal Aging and Mild Cognitive Impairment: A Tutorial

36/100 ✓ Peer-reviewed Health systems and care delivery American journal of speech-language pathology

Key finding: There are significant opportunities for speech-language pathologists (SLPs) to play important roles in the primary and secondary prevention of Alzheimer's disease and related dementias (ADRD) beyond current practices. +1 more finding

Full summary, score breakdown and related studies → Original source

Clinical Evaluation of the Revised Biological and Clinical Staging Criteria for Alzheimer Disease in China

49/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: = 0.007) in AD-signature regions and a numerically higher burden of vascular risk factors. +4 more findings

• Biomarkers

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CNS target engagement of high-dose DHA supplementation in older adults at risk for dementia: a randomised, double-blind, placebo-controlled trial

60/100 ✓ Peer-reviewed Prevention and risk EBioMedicine

Key finding: APOE ε4 carriers have increased Alzheimer's disease risk and altered omega-3 metabolism. +4 more findings

• Clinical Trials

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Equity and budget challenges associated with the employment of anti-amyloid monoclonal antibodies for early Alzheimer's Disease in Italy: A scenario analysis

38/100 ✓ Peer-reviewed Health systems and care delivery JAR life

Key finding: An estimated 42,000 patients in Italy are potentially eligible for anti-amyloid therapy. +4 more findings

• Treatments
• Policy
• Health Equity

Full summary, score breakdown and related studies → Original source

Leveraging artificial intelligence for analysis of the gut microbiome for dementia diagnosis: a scoping review and discussion

55/100 ✓ Peer-reviewed Digital health tools Frontiers in Dementia

Key finding: Distinct gut microbial compositions are associated with dementia. +1 more finding

• Digital Tools
• Diagnosis

Full summary, score breakdown and related studies → Original source

Attention Networks Connectivity After Cognitive Rehabilitation in Alzheimer’s Disease

34/100 ✓ Peer-reviewed Brain scans and imaging Journal of Geriatric Psychiatry and Neurology

Key finding: Enhanced connectivity between attention networks may be a characteristic of CR benefits in individuals with mild Alzheimer disease. +2 more findings

Full summary, score breakdown and related studies → Original source

Anticuerpos monoclonales antiamiloide y enfermedad de Alzheimer: ¿estamos preparados?

28/100 ✓ Peer-reviewed Genetics Kranion

Key finding: ResumenLa llegada de los anticuerpos monoclonales lecanemab y donanemab marca un cambio de paradigma en el tratamiento de la enfermedad de Alzheimer, transitando del nihilismo terapéutico a la era de las terapias modificadoras de la enfermedad.

Full summary, score breakdown and related studies → Original source

Prevalence of epilepsy and young-onset dementia in adults with intellectual disability: Contrasting Down syndrome and autism diagnoses

16/100 ⚠ Preprint — not yet peer-reviewed Costs and economics PsyArXiv

Key finding: Higher prevalence was observed in the ID group relative to the general population for epilepsy, young-onset ADRD, and their comorbidity. +4 more findings

Scored 39 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Microplastics-Induced Gut Microbiota Dysbiosis Accelerates Alzheimer's-Like Pathology and Cognitive Decline via the Gut-Brain Axis

45/100 ✓ Peer-reviewed Disease mechanisms Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Key finding: Translational validation using Alzheimer's Disease Neuroimaging Initiative (ADNI) plasma shows taurine is significantly lower in AD patients versus cognitively normal controls and inversely correlates with cognitive decline. +1 more finding

• Brain Biology

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Moving long-term care insurance upstream: A geriatric-syndrome-oriented framework for healthy aging in China

26/100 ✓ Peer-reviewed Health systems and care delivery Bioscience trends

Key finding: Existing quasi-experimental studies from China suggest that current LTCI pilots are associated with partial benefits in cognitive and psychological outcomes, changes in healthcare utilization including reduced hospitalization in some studies, modest improvements in health-related quality of life, and favorable frailty-related outcomes.

• Care Services
• Policy

Full summary, score breakdown and related studies → Original source

Development and Co‐Production of POST‐ID: A Post‐Diagnostic Behaviourally Informed Psychosocial Dementia Intervention for Adults With Intellectual Disabilities

41/100 ✓ Peer-reviewed Health systems and care delivery British Journal of Learning Disabilities

Key finding: Stakeholder feedback led to substantive refinements, including delivery across six structured sessions, prioritisation of emotional safety and identity preservation, and explicit focus on carer‐mediated behaviour change. +4 more findings

• Diagnosis
• Caregiving

Full summary, score breakdown and related studies → Original source

ActiTect: a generalizable machine learning pipeline for REM sleep behavior disorder screening through standardized actigraphy

50/100 ✓ Peer-reviewed Digital health tools npj Digital Medicine

Key finding: While wrist-worn actimeters hold significant potential for detecting RBD in large-scale screening efforts by capturing abnormal nocturnal movements, they require a reliable and efficient analysis pipeline. +2 more findings

• Digital Tools
• Diagnosis
• Other Dementias

Full summary, score breakdown and related studies → Original source

Clinical and neuroimaging correlates of motoric cognitive risk syndrome in cerebral small vessel disease: a cross-sectional study

48/100 ✓ Peer-reviewed Vascular contributions Frontiers in Aging Neuroscience

Key finding: Among 225 patients (mean age 65.4 years, 54.2% male), MCR prevalence was 16.4%. +4 more findings

• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

Agricultural pesticide use and Alzheimer’s disease dementia prevalence across US counties in a mixed supervised–unsupervised analysis

39/100 ✓ Peer-reviewed Risk factors Scientific Reports

Key finding: Out of 462 total pesticides screened, 112 demonstrated high selection stability and were grouped into 25 exposure clusters. +2 more findings

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Crossmodal plasticity effects of hearing loss and ageing in the human auditory cortex

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors bioRxiv

Key finding: ARHL is prevalent in a large proportion of older adults, and it is associated with an increased risk of cognitive decline and dementia. +4 more findings

• Risk Factors

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Smartphone-based detection of subtle memory decline in prodromal Alzheimer's disease

70/100 ✓ Peer-reviewed Cognitive tests and assessment NPJ digital medicine

Key finding: The MCI group showed greater decline than the CU group in the familiarity-dependent task, while stratifying the MCI group by beta-amyloid (Aβ) status (n = 21 Aβ-; n = 24 Aβ+) revealed greater change in memory precision for objects and familiarity-dependent memory in the MCI Aβ+ group. +1 more finding

• Early Stage
• Diagnosis
• Digital Tools

Full summary, score breakdown and related studies → Original source

Advance Care Planning and End-of-Life Care in Elderly: A Twenty-Four Month Cohort of Three Hundred and Fifty-Eight Patients with Serious Advanced Illness Advance Care Planning Cascade, Goals-of-Care Concordance, and Determinants Across Four Frailty Strata

47/100 ✓ Peer-reviewed End-of-life care Zenodo (CERN European Organization for Nuclear Research)

Key finding: ACP engagement cascaded through enrolment (86.0%), initial conversation (73.7%), goals of care documentation (60.9%), treatment preferences (49.7%), and accessible documents at end-of-life (41.3%). +4 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Advance Care Planning and End-of-Life Care in Elderly: A Twenty-Four Month Cohort of Three Hundred and Fifty-Eight Patients with Serious Advanced Illness Advance Care Planning Cascade, Goals-of-Care Concordance, and Determinants Across Four Frailty Strata

66/100 ✓ Peer-reviewed End-of-life care Zenodo (CERN European Organization for Nuclear Research)

Key finding: ACP engagement cascaded through enrolment (86.0%), initial conversation (73.7%), goals of care documentation (60.9%), treatment preferences (49.7%), and accessible documents at end-of-life (41.3%). +4 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

National Trends and Demographic Disparities in Mortality Involving Co-Recorded Parkinson’s Disease and Dementia in the United States, 1999–2025: A CDC WONDER Analysis

37/100 ✓ Peer-reviewed Disparities NeuroSci

Key finding: A sharp transient increase occurred in 2020, attributable to pandemic-related factors including disproportionate COVID-19 mortality among older adults with neurodegenerative conditions, care disruptions, and changes in death-certificate coding practices. +4 more findings

• Health Equity
• Other Dementias

Full summary, score breakdown and related studies → Original source

Age-Related Speech-in-Noise Hearing Loss in Parkinson’s Disease and APOE E4 Carriers

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors medRxiv

Key finding: The apolipoprotein E ( APOE ) E4 allele is the strongest genetic risk factor for Alzheimer’s disease and is associated with cognitive decline in PD, yet its relationship to hearing loss remains unclear. +3 more findings

• Genetics
• Risk Factors
• Other Dementias

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Functional-vs-Cognitive Decline Heterogeneity in Alzheimer’s Disease: LLM-Curation of Decades of Clinical Notes and GLP1RA Trial Design

16/100 ⚠ Preprint — not yet peer-reviewed Drug development Preprints.org

Key finding: Compared with matched non-AD controls, AD patients had lower ADCS-MCI-ADL scores at year 4 (28.1 versus 47.0 points; P<0.001) and higher FAQ impairment across follow-up. +2 more findings

• Treatments
• Clinical Trials

Scored 34 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Semaglutide attenuates neuroinflammation in male mice

48/100 ✓ Peer-reviewed Drug development Nature communications

Key finding: Together, these findings reveal how GLP-1R signaling in male mice orchestrates resolution of neuroinflammation through coordinated multi-cellular programs.

• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

Blood-based biomarkers for dementia with Lewy bodies

45/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD

Key finding: Reliable biomarkers are necessary, since a definitive diagnosis of DLB currently requires postmortem tissue analysis. +4 more findings

• Biomarkers
• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Lifestyle Interventions for Cognitive Decline and Dementia Prevention: A Network Meta-analysis (P9-13.014)

32/100 ✓ Peer-reviewed Prevention trials Neurology

Key finding: To compare and rank the relative and additive effects of lifestyle components including exercise, diet, cognitive training, vascular management, and digital delivery on cognitive outcomes and dementia prevention in older adults without dementia.

• Prevention
• Lifestyle

Full summary, score breakdown and related studies → Original source

Human TDP-43 expression worsens FTD-related phenotypes in progranulin-insufficient mice

36/100 ✓ Peer-reviewed Brain tissue and pathology Neurobiology of Disease

Key finding: Grn +/− :hTDP+ mice exhibited more dramatic impairment of social dominance than either Grn +/− or hTDP+ mice, which was associated with combined effects of progranulin insufficiency and hTDP expression on dendritic spines of neurons in the medial prefrontal cortex (mPFC). +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source