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Early MoCA predicts long-term cognitive and functional outcome and mortality after stroke
Zietemann V, Georgakis MK, Dondaine T, Müller C, Mendyk AM, Kopczak A, Hénon H, Bombois S et al.. Neurology, 2018-10-17
Topic: Risk, prevention and care in population studies
Objective To examine whether the Montreal Cognitive Assessment (MoCA) administered within 7 days after stroke predicts long-term cognitive impairment, functional impairment, and mortality. Methods MoCA was administered to 274 patients from 2 prospective hospital-based cohort studies in Germany (n = 125) and France (n = 149). Cognitive and functional outcomes were assessed at 6, 12, and 36 months after stroke by comprehensive neuropsychological testing, the Clinical Dementia Rating (CDR) scale, the modified Rankin Scale (mRS), and Instrumental Activities of Daily Living (IADL) and analyzed with generalized estimating equations.
Key findings
- Methods MoCA was administered to 274 patients from 2 prospective hospital-based cohort studies in Germany (n = 125) and France (n = 149).
- Cognitive and functional outcomes were assessed at 6, 12, and 36 months after stroke by comprehensive neuropsychological testing, the Clinical Dementia Rating (CDR) scale, the modified Rankin Scale (mRS), and Instrumental Activities of Daily Living (IADL) and analyzed with generalized estimating equations.
- All-cause mortality was investigated by Cox proportional hazard models.
- Analyses were adjusted for demographic variables, education, vascular risk factors, premorbid cognitive status, and NIH Stroke Scale scores.
Why it matters
This cohort study examined whether the Montreal Cognitive Assessment given within 7 days after stroke predicts long-term cognitive and functional outcome and mortality in 274 patients. It is about predicting outcomes after stroke and does not test any treatment, cure, or prevention for Alzheimer's disease.
Study details
- Study designcohort study
- Participants125
- Effect sizeOR 5.03
- Evidence strengthModerate
How this study scored 69/100
Published in a leading specialty journal, and it is a cohort study following people over time. Scored zero for randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 2 / 4 | 125 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 152 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 15.2 citations a year over 10 year(s) since 2018 |
| Impact for its field and year | 4 / 6 | Cited 8.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 3 / 4 | Cited 57 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Martin Dichgans: h-index 146 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Inserm: institution h-index 1,988 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 7 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 30333158) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 69 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Zietemann, V., Georgakis, M. K., Dondaine, T., Müller, C., Mendyk, A. M., Kopczak, A., et al. (2018). Early MoCA predicts long-term cognitive and functional outcome and mortality after stroke. Neurology. https://doi.org/10.1212/wnl.0000000000006506
Vancouver
Zietemann V, Georgakis MK, Dondaine T, Müller C, Mendyk AM, Kopczak A, et al. Early MoCA predicts long-term cognitive and functional outcome and mortality after stroke. Neurology. 2018. doi:10.1212/wnl.0000000000006506. PMID: 30333158.
BibTeX
@article{zietemann2018-30333158,
author = {Zietemann, V. and Georgakis, M. K. and Dondaine, T. and Müller, C. and Mendyk, A. M. and Kopczak, A. and Hénon, H. and Bombois, S. and others},
title = {{Early MoCA predicts long-term cognitive and functional outcome and mortality after stroke}},
journal = {Neurology},
year = {2018},
doi = {10.1212/wnl.0000000000006506},
pmid = {30333158},
url = {https://doi.org/10.1212/wnl.0000000000006506}
}
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