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Multisite study of the relationships between antemortem [ 11 C]PIB‐PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology
Renaud La Joie, Nagehan Ayakta, William W. Seeley, Ewa Borys, Adam L. Boxer, Charles S DeCarli, Vincent Doré, Lea T. Grinberg, Eric Jinsheng Huang, Ji‐Hye Hwang, Miloš D. Ikonomović, Clifford R. Jack, William J. Jagust, Lee‐Way Jin, William E. Klunk, Julia Kofler, Orit H. Lesman‐Segev, Samuel Neal Lockhart, Val J. Lowe, Colin Louis Masters, Chester A. Mathis, Catriona McLean, Bruce L. Miller, Daniel Mungas, James P. O’Neil, John Olichney, Joseph E. Parisi, Ronald Carl Petersen, Howard J. Rosen, Christopher Cleon Rowe, Salvatore E. Spina, Prashanthi Vemuri, Victor L. Villemagne, Melissa Erin Murray, Gil D. Rabinovici. Alzheimer s & Dementia, 2018-10-19
Topic: Amyloid, tau and blood-test diagnosis
Abstract Introduction We sought to establish the relationships between standard postmortem measures of AD neuropathology and antemortem [ 11 C]PIB–positron emission tomography ([ 11 C]PIB‐PET) analyzed with the Centiloid (CL) method, a standardized scale for Aβ‐PET quantification. Methods Four centers contributed 179 participants encompassing a broad range of clinical diagnoses, PET data, and autopsy findings. Results CL values increased with each CERAD neuritic plaque score increment (median −3 CL for no plaques and 92 CL for frequent plaques) and nonlinearly with Thal Aβ phases (increases were detected starting at phase 2) with overlap between scores/phases. PET‐pathology associations were comparable across sites and unchanged when restricting the analyses to the 56 patients who died within 2 years of PET. A threshold of 12.2 CL detected CERAD moderate‐to‐frequent neuritic plaques (area under the curve = 0.910, sensitivity = 89.2%, specificity = 86.4%), whereas 24.4 CL identified intermediate‐to‐high AD neuropathological changes (area under the curve = 0.894, sensitivity = 84.1%, specificity = 87.9%). Discussion Our study demonstrated the robustness of a multisite Centiloid [ 11 C]PIB‐PET study and established a range of pathology‐based CL thresholds.
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APA 7th
La Joie, R., Ayakta, N., Seeley, W. W., Borys, E., Boxer, A. L., DeCarli, C. S., et al. (2018). Multisite study of the relationships between antemortem [ 11 C]PIB‐PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology. Alzheimer s & Dementia. https://doi.org/10.1016/j.jalz.2018.09.001
Vancouver
La Joie R, Ayakta N, Seeley WW, Borys E, Boxer AL, DeCarli CS, et al. Multisite study of the relationships between antemortem [ 11 C]PIB‐PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology. Alzheimer s & Dementia. 2018. doi:10.1016/j.jalz.2018.09.001. PMID: 30347188.
BibTeX
@article{lajoie2018-30347188,
author = {La Joie, Renaud and Ayakta, Nagehan and Seeley, William W. and Borys, Ewa and Boxer, Adam L. and DeCarli, Charles S and Doré, Vincent and Grinberg, Lea T. and Huang, Eric Jinsheng and Hwang, Ji‐Hye and Ikonomović, Miloš D. and Jack, Clifford R. and Jagust, William J. and Jin, Lee‐Way and Klunk, William E. and Kofler, Julia and Lesman‐Segev, Orit H. and Lockhart, Samuel Neal and Lowe, Val J. and Masters, Colin Louis and Mathis, Chester A. and McLean, Catriona and Miller, Bruce L. and Mungas, Daniel and O’Neil, James P. and Olichney, John and Parisi, Joseph E. and Petersen, Ronald Carl and Rosen, Howard J. and Rowe, Christopher Cleon and Spina, Salvatore E. and Vemuri, Prashanthi and Villemagne, Victor L. and Murray, Melissa Erin and Rabinovici, Gil D.},
title = {{Multisite study of the relationships between antemortem [ 11 C]PIB‐PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology}},
journal = {Alzheimer s \& Dementia},
year = {2018},
doi = {10.1016/j.jalz.2018.09.001},
pmid = {30347188},
url = {https://doi.org/10.1016/j.jalz.2018.09.001}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 35 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Why it matters
In 179 people across four centers, amyloid PET values on the Centiloid scale measured before death rose with the amount of plaque found at autopsy. A threshold of 12.2 Centiloids detected moderate-to-frequent plaques, and 24.4 identified intermediate-to-high Alzheimer's brain changes.
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How this study scored 54/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on strength of evidence, so that was left out: it earned 51 of the 95 points we could judge it on, which is 54 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | — / 5 | No evidence rating recorded — left out of this score |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 318 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 31.8 citations a year over 10 year(s) since 2018 |
| Impact for its field and year | 4 / 6 | Cited 13.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 3 / 4 | Cited 171 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Gil D. Rabinovici: h-index 116 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of California, Berkeley: institution h-index 2,012 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 15 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 30347188) |
| Free to read | 2 / 2 | Free to read |
| Points | 51 / 95 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 51 of the 95 points we could judge it on is 54 out of 100. |
| Total | 54 / 100 | — |
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Read the original
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